Cohort Descriptives

Variable Response
Cohort Name The Caerphilly Prospective Study
Cohort Acronym CaPS
DOI Yoav Ben-Shlomo, Y. (2017). CaPS [Data set]. Dementias Platform UK. https://doi.org/10.48532/011000
Study Overview The Caerphilly Prospective Study (CAPS), also known as the Caerphilly Heart Disease Study, is an epidemiological population study set up to investigate relationships between lifestyle and other factors with incident cardiovascular disease in men from Caerphilly and surrounding villages in Wales. When CAPS started it was only the second population-based study of cardiovascular disease in the UK. Phase I began in 1979 until 1983. The cohort was re-examined after approximately 5 years: Phase II (1984-1988), Phase III (1989-1993), and Phase IV (1993-1996) Follow-up research continued from 1997-2016, with 2 postal questionnaires enabling data to be collected on stroke events and new non-fatal myocardial infarctions and more recently disability and functional limitation. All deaths and cancer registrations flagged (from the NHSCR) are added to the database. Phase V (2002-2004) was the 4th follow-up with questionnaires, cognitive and physical measures. CAPS' initial aim was to examine the importance in the development of IHD of lipids, haemostatic factors, and hormones (such as testosterone, cortisol and insulin). Other hypotheses were added for a specific interest in platelet function and psychosocial variables. As the cohort has aged, other outcomes were added, including stroke events, hearing problems, cognitive function disability and functional limitation.
#Subjects at Baseline 2512 baseline (+447 added in Phase II = 2959)
Institution Name University of Bristol
Department Name School of Social and Community Medicine
City Bristol
Study/Database Website

https://www.maelstrom-research.org/mica/study/caps

Principal Investigator (PI) Prof Yoav Ben-Shlomo
Key Study References

Please see publications section

Population Based Study? Yes
Family Based Study? No
Clinical based sample? No
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? Face to face at Clinics and completing questionnaires at home.
Who carries out data collection? A combination of interviewers and clinicians.
Does this take place in participants' homes or at a central location? Home and Central (Clinics): Some follow up has been carried out via postal contact.
Do participants take part individually or are families/partners involved? Individually
Dementia cases ascertained as part of study: Yes
Diagnosis based on review of existing clinical data Yes
How many times followed up? 4
Study start date 1/7/1979 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? No
Inclusion criteria 45-59 years old. Lives in Caerphilly region. Male. On electoral register and/or general practice list.
Exclusion criteria None at inception

Descriptives

Variable type
The Caerphilly Prospective Study
CaPS
Yoav Ben-Shlomo, Y. (2017). CaPS [Data set]. Dementias Platform UK. https://doi.org/10.48532/011000
The Caerphilly Prospective Study (CAPS), also known as the Caerphilly Heart Disease Study, is an epidemiological population study set up to investigate relationships between lifestyle and other factors with incident cardiovascular disease in men from Caerphilly and surrounding villages in Wales. When CAPS started it was only the second population-based study of cardiovascular disease in the UK. Phase I began in 1979 until 1983. The cohort was re-examined after approximately 5 years: Phase II (1984-1988), Phase III (1989-1993), and Phase IV (1993-1996) Follow-up research continued from 1997-2016, with 2 postal questionnaires enabling data to be collected on stroke events and new non-fatal myocardial infarctions and more recently disability and functional limitation. All deaths and cancer registrations flagged (from the NHSCR) are added to the database. Phase V (2002-2004) was the 4th follow-up with questionnaires, cognitive and physical measures. CAPS' initial aim was to examine the importance in the development of IHD of lipids, haemostatic factors, and hormones (such as testosterone, cortisol and insulin). Other hypotheses were added for a specific interest in platelet function and psychosocial variables. As the cohort has aged, other outcomes were added, including stroke events, hearing problems, cognitive function disability and functional limitation.
2512 baseline (+447 added in Phase II = 2959)
University of Bristol
School of Social and Community Medicine
Bristol
https://www.maelstrom-research.org/mica/study/caps
Prof Yoav Ben-Shlomo
Please see publications section
Yes
No
No
Yes
Yes
Yes
Face to face at Clinics and completing questionnaires at home.
A combination of interviewers and clinicians.
Home and Central (Clinics): Some follow up has been carried out via postal contact.
Individually
Yes
Yes
4
1/7/1979 12:00:00 AM
Yes
No
45-59 years old. Lives in Caerphilly region. Male. On electoral register and/or general practice list.
None at inception

Administration

Variable type
Age Of Subject
Consent form signed
Date Of Birth
Date Of Medical Examinations
Unique Number Of Subject

Sociodemographic

Sub-category Variable type Baseline 1 2 3 4
Deprivation Housing tenure         Y
Deprivation How old is your car         Y
Deprivation How well managing financially these days         Y
Deprivation Own one or more cars         Y
Deprivation Social class   Y      
Education Age at which left school     Y    
Education Apprenticeship completed     Y    
Education CSE/GCE O level/equivalent     Y    
Education Degree/higher degree     Y    
Education GCE A level/equivalent     Y    
Education Qualifications gained     Y    
Employment Employment status Y Y Y Y Y
Employment Employment/job details Y Y Y    
Employment Job security   Y      
Employment Pension         Y
Employment Promotion details   Y      
Employment Rate of pay   Y      
Employment Retirement details     Y    
Employment Unemployment   Y      
Employment When did you start current job/finish previous job   Y      
Marital Status Age at first marriage Y        
Marital Status Marital status Y Y Y   Y
Religion Belief in a god/spiritual power that influences own life         Y
Religion Go to church/other place of worship     Y Y Y
Religion How often attend religious services     Y   Y

Family History

Sub-category Variable type Baseline 1 2 3 4
Children Total number of children   Y      
Extended Any near relatives had a coronary thrombosis Y Y Y    
Father Age of father now/at death     Y    
Father Father alive or dead     Y    
Mother Age of mother now/at death     Y    
Mother How many liveborn children did mother have Y        
Mother Mother alive or dead     Y    

Early Life History

Sub-category Variable type Baseline 1 2 3 4
Birth Birth weight Y        
Birthplace Place of birth Y        
Breastfed Whether breast fed/how long for Y        
Childhood Environment Father's occupation during childhood Y        

Physical Health Status

Sub-category Variable type Baseline 1 2 3 4
Cancer Been diagnosed with cancer         Y
Cardiothoracic Angina   Y Y Y Y
Cardiothoracic Heart attack Y Y Y Y Y
Cardiothoracic Heart failure         Y
Cardiothoracic High blood pressure Y Y Y Y Y
Cardiothoracic High cholesterol         Y
Cardiothoracic Ischaemic heart disease   Y Y Y  
Cardiothoracic Other heart problems         Y
Cerebrovascular TIA/stroke (ischaemic/haemorrhagic) Y Y Y Y Y
Endocrinology Thyroid trouble Y Y      
ENT Difficulty following TV programmes without an aid         Y
ENT Difficulty having conversation with a group         Y
ENT Hearing difficulties/sensitive to noise   Y     Y
ENT Nasal congestion/obstruction/discharge     Y    
ENT Tinnitus     Y Y Y
Eyes Cataracts       Y  
Eyes Eyesight getting worse         Y
Gastrointestinal Suffer from indigestion Y     Y  
General Health Chilblains   Y      
General Health Clots phlebitis/inflammation of veins in legs Y Y      
General Health Diabetes Y Y Y Y Y
General Health Falls         Y
General Health Had to change job/off work due to ill health   Y Y    
General Health Head injury     Y   Y
General Health Kidney disease (chronic) Y Y      
General Health Long standing illness/disability/infirmity   Y     Y
General Health Prostatism/prostate trouble         Y
General Health Restless legs/bothersome twitches     Y    
General Health Self-assessment of general health       Y Y
General Health Yellow jaundice/liver disease Y Y      
Immunological Allergies     Y   Y
Neurological Epilepsy         Y
Pain Chest pain/discomfort Y Y Y Y Y
Pain Ever see doctor about pain Y Y Y Y  
Pain Leg pain/intermittent claudication   Y Y Y Y
Pain Other pain/discomfort         Y
Pain Pain while walking Y Y Y Y Y
Respiratory Respiratory infections         Y
Respiratory Shortness of breath while walking/washing/dressing         Y
Rheumatology Arthritis         Y
Rheumatology Gout Y Y Y Y  
Rheumatology Swelling in joints     Y   Y

Healthcare Utilisation

Sub-category Variable type Baseline 1 2 3 4
Hospitalisation Hospital admission details Y Y Y Y Y
Hospitalisation Hospital diagnosis       Y  
Hospitalisation Referred to hospital about problems with hearing         Y
Medications Antihypertensives         Y
Medications Aspirin/headache tablets Y Y   Y Y
Medications Asthma inhaler/medication         Y
Medications Cholesterol medication         Y
Medications Insulin/diabetes medication         Y
Medications Medication (prescribed/self-prescribed) Y Y Y Y Y
Medications Medication for heart problems         Y
Medications Number of medications Y Y Y Y  
Medications Respiratory drugs   Y      
Medications Sleeping tablets     Y   Y
Surgery Abdominal/chest surgery         Y
Surgery Ever had tonsils/adenoids/appendix removed Y        

Life Functionality

Sub-category Variable type Baseline 1 2 3 4
Assistive Devices Gets disability living allowance         Y
Assistive Devices Hearing aid       Y Y
Assistive Devices Walking aid         Y
Daily Living Ability to do usual activities (washing/dressing/feeding)         Y

Psychological Status

Sub-category Variable type Baseline 1 2 3 4
Personality Bortner scale   Y      
Personality Framingham Type A Scale Y Y      
Personality Jenkins activity score   Y      
Personality Malaise Inventory Y        
Personality Weinstein noise sensitivity   Y      
Quality Of Life Eyesight/hearing have interfered with everyday life         Y
Quality Of Life Shaving details Y        
Sleep Places/situations likely to fall asleep in     Y   Y
Sleep Sleep pattern disturbance questions     Y   Y
Sleep Trouble falling/staying asleep Y   Y    
Wellbeing Bothered by nervousness/shaking Y        
Wellbeing Concentration has changed/difficulty concentrating         Y
Wellbeing Embarrassed/frustrated/lonely/sad because of eyesight/hearing         Y
Wellbeing Feel under a great deal of tension Y        
Wellbeing General Self-Efficacy Scale         Y
Wellbeing Health Attitude Inventory   Y Y    
Wellbeing How feel about life         Y
Wellbeing Job satisfaction   Y      
Wellbeing Satisfaction With Life Scale         Y
Wellbeing Troubled by feelings of tenseness/tightness/restlessness/inability to relax Y        
Wellbeing Worried about things Y        

Mental Health Status

Sub-category Variable type Baseline 1 2 3 4
Mood Anxious/depressed         Y
Mood Framingham anger scale   Y      
Mood General health questionnaire (GHQ)   Y Y Y Y
Mood Hospital Anxiety and Depression Scale         Y
Mood Positive and Negative Affect Schedule         Y
Mood Spielberger anxiety questionnaire   Y      

Cognition

Sub-category Variable type Baseline 1 2 3 4
Cognitive Performance Alice Heim Group Ability Test (AH4)     Y Y Y
Cognitive Performance Cambridge Cognitive Function (CAMCOG)     Y Y Y
Cognitive Performance Extensive cognition questionnaire     Y Y Y
Cognitive Performance Incidental memory tests       Y  
Cognitive Performance MMSE (Mini Mental State Exam)     Y Y Y
Cognitive Performance NART (National Adult Reading Test)     Y Y Y
Cognitive Performance Passage of time tests     Y Y  
Cognitive Performance Reaction Time tests (simple/choice)     Y Y Y
Cognitive Performance Rivermead immediate/delayed recall tests     Y Y  
Cognitive Status Parkinson's disease         Y
Cognitive Status Severity of cognitive problem         Y
Cognitive Status Type of cognitive impairment no dementia (CIND)         Y
Cognitive Status Type of dementia         Y
Self Report Cognitive Status Memory has changed/memory difficulty         Y

Lifestyle

Sub-category Variable type Baseline 1 2 3 4
Alcohol Alcohol consumed in last 24 hours       Y  
Alcohol Ever had a drink first thing in morning to steady nerves/get rid of a hangover         Y
Alcohol Felt bad/guilty/should cut down on drinking         Y
Alcohol Intake of different alcohol types Y Y Y Y Y
Alcohol People annoyed by criticising your drinking         Y
Alcohol Whether take drinks with alcohol/usual type of alcoholic drink Y Y Y Y Y
Diet Carbohydrate intake Y Y Y    
Diet Dairy intake Y Y Y    
Diet Fat intake Y Y Y    
Diet Fruit/veg intake Y Y Y    
Diet Hot/cold drinks intake Y Y Y    
Diet On a special diet Y Y Y    
Diet Protein (meat/fish/egg) intake Y Y Y    
Diet Snack/sugar intake Y Y Y    
Diet Vitamin B6 intake Y Y Y    
Diet McCance and Widdowson's General Food Code Y Y Y    
Diet Eating habits - number of meals Y Y Y    
Digital Technology Average hours a day spent watching TV     Y Y Y
Digital Technology How often usually spent using the internet         Y
Digital Technology How often watch news on TV/hear it on the radio         Y
Leisure Been on holiday in last year         Y
Leisure Belong to any clubs/organisations     Y Y Y
Leisure How often attended a trades union/political party meeting         Y
Leisure How often play the lottery         Y
Leisure How often usually do crossword puzzles         Y
Leisure Minnesota activity index   Y      
Leisure Own a pet     Y Y Y
Leisure Various leisure/social activities     Y Y Y
Leisure Whether voted in last general/local election         Y
Leisure Which daily/Sunday paper read most regularly     Y Y Y
Physical Ever box seriously as a sport         Y
Physical Gardening/DIY     Y Y Y
Physical Heavy work/exercise in free time and how long Y        
Physical Physical exercise eg ball games/golf/jogging/walking     Y Y Y
Sexual Frequency of orgasm Y        
Smoking Age started/stopped smoking     Y    
Smoking Brand of cigarettes smoked   Y      
Smoking Do you smoke at all/current smoker Y Y Y Y Y
Smoking Ever been a regular/significant smoker Y Y Y Y Y
Smoking How long ago did you give up Y Y   Y Y
Smoking How many smokes per day (past/present) Y Y Y Y Y
Smoking Time of last smoke       Y  
Travel Currently have a driving license         Y

Physical Environment

Sub-category Variable type Baseline 1 2 3 4
Housing Does danger through traffic at home worry you   Y      
Housing Does living room/bedroom face the road   Y      
Housing Household type/accommodation         Y
Housing How many people do you live with         Y
Housing How many people normally eat in household Y Y Y    
Housing How much keep a window open in living room/bedroom   Y      
Housing Number of bedrooms in your home         Y
Housing When did you move into your home   Y      
Work Does noise/danger at work annoy you   Y      
Work How far walk/cycle to work Y        
Work How long does it take to travel to/from work   Y      
Work How many hours per week spent at work   Y      
Work How much time spent walking/sitting at job   Y      
Work How often lifting/carrying heavy things in job   Y      
Work Karasek score   Y      
Work Method of travel to/from work   Y      
Work Physical work conditions   Y      
Work Wear ear protectors at work   Y      
Work Work near noisy machines/engines/tools   Y      

Social Environment

Sub-category Variable type Baseline 1 2 3 4
Multimedia How often do you make a personal phone call/write a personal letter         Y
Social Care (Given) Any friends/relatives you look after on a daily basis       Y  
Social Care (Given) How often usually care for other adults         Y
Social Interaction How many friends/acquaintances do you see/talk to often     Y Y Y
Social Interaction How often do you visit/receive visits from friends/acquaintances     Y    
Social Interaction How often regularly look after grandchildren         Y
Social Interaction How often visit/receive visits from relatives not in household     Y Y  
Social Interaction Marmot social support   Y      
Social Interaction Questions about people close to participant     Y Y Y

Physical Examination

Sub-category Variable type Baseline 1 2 3 4
Anthropometry Arm girth   Y      
Anthropometry Circumference of various body parts Y Y Y   Y
Anthropometry Diameter of various body parts Y Y Y    
Anthropometry Height/sitting height Y Y   Y Y
Anthropometry Shoulder breadth Y Y      
Anthropometry Skinfold thickness of biceps/triceps Y        
Anthropometry Weight at 18 Y        
Anthropometry Weight now Y Y Y Y Y
Ear Audiometry measurement   Y   Y  
Heart Blood pressure Y Y Y Y  
Heart Carotid bruits     Y Y  
Heart ECG Y Y Y Y  
Heart Pulse rate/wave analysis/velocity Y Y Y Y  
Lung Forced expiratory volume Y Y     Y
Lung Forced volume/vital capacity Y Y     Y
Mobility Ability to walk around         Y
Mobility Difficulty doing everyday movements         Y
Mobility Flamingo balance test         Y
Nose Olfactory test         Y

Biosample Assays

Sub-category Variable type Baseline 1 2 3 4
Biochemistry Albumin Y Y Y    
Biochemistry Alkaline phosphatase Y Y Y    
Biochemistry Alpha 1 antitrypsin/2 antiplasmin/macroglobulin   Y      
Biochemistry Antioxidants     Y    
Biochemistry Apolipoprotein A-I/A-II/B   Y      
Biochemistry Aspartate transaminase Y Y Y    
Biochemistry Bicarbonate   Y Y    
Biochemistry Bilirubin Y Y Y    
Biochemistry Calcium/magnesium/potassium/sodium Y Y Y    
Biochemistry Chloride   Y Y    
Biochemistry Coagulation factors/APTT Y Y Y Y  
Biochemistry Creatinine Y Y Y    
Biochemistry D-dimer gold standard   Y      
Biochemistry Gamma glutamyl transferase   Y Y    
Biochemistry Glucose Y Y Y    
Biochemistry Homocysteine   Y      
Biochemistry Insulin   Y      
Biochemistry Interleukin 6 (iL-6)   Y      
Biochemistry Parathyroid hormone     Y    
Biochemistry Phosphate Y Y Y    
Biochemistry Plasminogen   Y      
Biochemistry PTA urate Y        
Biochemistry T3/T4 Y        
Biochemistry Thromboxane B2   Y      
Biochemistry Total cholesterol Y Y Y Y  
Biochemistry Total protein Y Y Y    
Biochemistry Triglycerides Y Y Y Y  
Biochemistry Urea Y Y Y    
Biochemistry Uricase Y        
Biochemistry Vitamins (eg folate)     Y    
Haematology Complete blood count Y Y Y Y  
Haematology Mean cell/platelet volume Y Y Y Y  
Haematology Platelet tests   Y Y Y  
Haematology Platelet/red cell distribution width Y Y      
Haematology Red/white blood cell count Y Y Y Y  
Haematology Viscosity Y Y Y Y  

Built Environment

Sub-category Variable type Baseline 1 2 3 4
Pollution Does traffic noise at home annoy you   Y Y    
Pollution Traffic noise disturbs conversation/listening to the TV   Y Y    
Pollution Traffic noise makes concentration difficult   Y Y    
Pollution Traffic noise makes it difficult to fall asleep/wake you up   Y Y    
Pollution Traffic noise makes relaxation difficult   Y Y    
Pollution Traffic noise makes you nervous/tense   Y