| Cohort Name |
Whitehall II (MRI Substudy) |
| Cohort Acronym |
Whitehall II MRI |
| Study Overview |
The Whitehall II (MRI Substudy) randomly recruited 800 participants from wave 11 of the Whitehall II study to come to Oxford for detailed neuropsychologcal, psychiatric and MRI investigations between 2012 and 2016. Data on T1-weighted structural MRI, FLAIR, T2*-weighted, DTI and resting state fMRI are available for most participants. Just like the Whitehall II study, the MRI substudy aims to understand the causes of age-related heterogeneity in brain and mental structure and function. By combining over 30 years of data on social inequalities, lifestyle and chronic disease with new clinical measures of cognitive function, mental disorders and physical functioning, insights into individual and social differences and brain mechanisms in the development of frailty, disability, dependence, depression and dementia can be gained. |
| #Subjects at Baseline |
625 men and 150 women with structural MRI |
| Institution Name |
University of Oxford |
| Department Name |
Department of Psychiatry |
| City |
Oxford |
| Study/Database Website |
https://gtr.ukri.org/projects?ref=G1001354; https://clinicaltrials.gov/ct2/show/NCT03335696 |
| Principal Investigator (PI) |
Professor Klaus Ebmeier |
| Key Study References |
https://www.psych.ox.ac.uk/publications/search?keywords=Whitehall&forthcoming=on |
| Population Based Study? |
Yes |
| Family Based Study? |
No |
| Clinical based sample? |
No |
| Is there follow-up data available? |
Yes |
| Were participants included prior to development of dementia (may refer to controls only)? |
Yes |
| Were participants included prior to development of MCI (may refer to controls only)? |
Yes |
| How is data collected? |
In person |
| Who carries out data collection? |
Interviewers and clinical staff: Mix of trained psychologists and clinicians. Incidental findings reviewed by clinicians. |
| Does this take place in participants' homes or at a central location? |
Central |
| Do participants take part individually or are families/partners involved? |
Individually |
| Dementia cases ascertained as part of study: |
No |
| Diagnosis based on review of existing clinical data |
No |
| Was diagnosis/primary outcomes made blind to exposure variables? |
No |
| How many times followed up? |
≥1 after scan as part of Whitehall II UCL Study |
| # Subjects at Follow-up |
751 |
| Study start date |
18th April 2012 |
| Study end date |
1st December 2016 |
| Is study ongoing? |
No |
| Is study still recruiting? |
No |
| Inclusion criteria |
Civil servant working in the London offices of 20 Whitehall departments in 1985-88. Aged 35-55. Capacity to consent. |
| Exclusion criteria |
Not suitable to travel to Oxford and have MRI 3T scan |