Cohort Descriptives

Variable Response
Cohort Name UK Biobank
Cohort Acronym UK Biobank
Study Overview UK Biobank aims to assess the relevance of a very wide range of exposures on a very wide range of health-related outcomes. It is a large prospective study to investigate the role of genetic factors, environmental exposures and lifestyle in the causes of major diseases of late and middle age. During 2006-2010, UK Biobank conducted its recruitment phase of more than 500,000 participants who gave their consent, answered questions, had physical measurements and gave samples (blood, urine and saliva) at a baseline assessment visit. Follow-up of their health is now being conducted through medical and other health-related records. Access systems have been developed to facilitate use of the UK Biobank Resource by bona fide researchers for health-related research that is in the public interest. NB: Due to the size and complexity of Biobank and the comprehensiveness of the Biobank website, much additional information is available in the Documents section of this profile, or in hyperlinks embedded within the cohort profile. Publications can be seen here: http://www.ukbiobank.ac.uk/published-papers/
#Subjects at Baseline 503, 316
Institution Name UK Biobank
Department Name UK Biobank Coordinating Centre
City Stockport
Study/Database Website

https://www.biobank.ac.uk

Principal Investigator (PI) Prof Sir Rory Collins
Key Study References

Please see Literature section

Population Based Study? Yes
Family Based Study? No
Clinical based sample? No
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? A combination of in person, postal and internet
Who carries out data collection? Interviewers and clinical staff: Key staff are research nursing and technical staff.
Does this take place in participants' homes or at a central location? Home and Central: Baseline visit at central location (office space). Pedometry (100,000) and emailed questionnaires (300,000) sent to participants and carried out at home. There are additional web based questionnaires that will also be carried out at home.
Do participants take part individually or are families/partners involved? Individually
Dementia cases ascertained as part of study: No
How regular is follow-up? Subgroups may be followed more frequently.
Study start date 1/1/2006 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? No
Inclusion criteria Age 40-69 years. Capacity to consent. Lived within 20-25 miles of one of the assessment centres.
Exclusion criteria UK Biobank did not enrol potential participants who express the view that they would want to be withdrawn should they lose mental capacity or die because this would reduce the value of the resource for research.

Administration

Variable type Variables generally collected
Study ID Y
Age Y
Sex Y

Sociodemographic

Variable type Variables generally collected
Age Y
Age at time of diagnosis of dementia Y
Sex Y
Ethnicity Y
Years of education Y
Level of education Y
Employment Status Y
Socioeconomic status measures Y

Physical Health Status

Variable type Variables generally collected
Cardiovascular disease data Y
Myocardial infarction Y
Medication use for CVD Y
Hypertension Y
Systolic/diastolic BP Y
Mean arterial pressure Y
Hypotension Y
Hypercholesterolemia Y
Cancer Y
Diabetic Status Y
Stroke data Y
Stroke type Y
Transient Ischemic Attack Y
Carotid plaques Y
Head trauma data Y
Loss of consciousness Y

Healthcare Utilisation

Variable type Variables generally collected
Medication use Y
Medication use for CVD Y
Hospital utilisation Y

Psychological Status

Variable type Variables generally collected
Personality evaluation Y
Resilience evaluation Y
Sleep assessment Y
Psychosocial questionnaire Y
Lifestyle questionnaire Y
Environment questionnaire Y

Mental Health Status

Variable type Variables generally collected
Apathy evaluation Y
Anxiety measure Y
Psychosocial questionnaire Y
Lifestyle questionnaire Y
Environment questionnaire Y
Life Events Y
Childhood Trauma Screen (CTS) Y
Adulthood Questions Y
PTSD Checklist -5 (PCL-5) Y

Cognitive Status

Variable type Variables generally collected
Alzheimer's dementia Y
Lewy Body Disease Y
Huntington's Disease Y
Parkinson's Disease Y
Frontotemporal Dementia Y
Vascular Dementia Y

Lifestyle

Variable type Variables generally collected
Smoking Y
Pack years Y
Passive smoking Y
Current smoking Y
Former smoking Y
Alcohol Y
Units per day/week vs weekend Y
Specified beverage type (wine, spirits, beers) Y
Abstainers/former users Y
Binge drinking Y
Physical activity and exercise Y
Type of heavy: heavy, light Y
Exercise duration Y
Occupation possible job matrices Y
Objective measures of activity Y
Objective measure of fitness Y
Diet: Carbs, protein, fats, fish oil Y
Anti-oxidants Y
Vegetarian? Y
Shortage of food Y
Coffee and Caffeine Y
Vitamin A,B,E Y
Fat intake MUFA, PUFA Y
Food questionnaires Y
Other dietary items Y

Physical Environment

Variable type Variables generally collected
Living situation Y
Environment questionnaire Y

Social Environment

Variable type Variables generally collected
Environment questionnaire Y

Physical Examination

Variable type Variables generally collected
Blood pressure Y
Weight Y
Height Y
Neurological examination Y
Heart Rate Y
Anthropometry Y
Waist circumference Y
Hip circumference Y
Bioimpedence measures Y
ECG Y
Respiratory examination Y
PEFR Y
Spirometry Y
Gait assessment (Self-report about gait) Y
Opthalmic examination Y
Acuity Y
BMI Y
Fat percentage Y
Dyslipidemia Y
Blood lipids Y
Metabolic syndrome Y

Biosample Assays

Variable type Variables generally collected
Plasma Y
Serum Y
RNA Y
DNA Y
Urine Y
Sodium Y
Potassium Y
Microalbumin Y
Enzymatic creatinine Y
Saliva (subgroup) Y
Mitochondrial function Y

Digital Phenotyping

Variable type Variables generally collected
Visual Memory Y
Verbal Memory Y
Visuospatial Function Y
Attention Y
Reaction time Y
Working Memory Y
Latent Memory Y
Nonverbal reasoning (matrix) Y
IQ data Y

Imaging

Variable type Variables generally collected
Structural T1 Y
Fluid attenuation inversion recovery (FLAIR) Y
Diffusion imaging (DTI/DWI) Y
f-MRI (task) Y
f-MRI (rest) Y

Genomics

Variable type Variables generally collected
GWAS platform: Affymetrix Y
APOE gene screening Y
TREM 2 gene screening Y
APP gene screening Y
PSEN1 gene screening Y
PSEN2 gene screening Y
GRN gene screening Y
MAPT gene screening Y
C9ORF72 gene screening Y
VCP gene screening Y
CHMP2B gene screening Y
TDP-43 gene screening Y
PRNP gene screening Y
SNCA gene screening Y
LRRK2 gene screening Y
PINK1 gene screening Y
PARK2 gene screening Y
PARK7 gene screening Y
NOTCH3 gene screening Y
CST3 gene screening Y
TTR gene screening Y
GSN gene screening Y
ITM2B gene screening Y
HTT gene screening Y
NPC1 gene screening Y
NPC2 gene screening Y

Metabolomics

Variable type Variables generally collected
CRP (c-reactive protein) Y
eGFR (estimated Glomular Filtration Rate) Y
Glucose Y
HbA1c Y
Lipids Y
Liver Function Tests Y
Serum creatinine Y

Environmental Assessment

Variable type Variables generally collected
Environment questionnaire Y