| Cohort Name |
PRIME (etude PRospective sur l'Infarctus du MyocardE) |
| Cohort Acronym |
PRIME |
| DOI |
Linden, G. (2017). PRIME [Data set]. Dementias Platform UK. https://doi.org/10.48532/039000 |
| Study Overview |
The PRIME study was set up in 1991 as a prospective population-based study of risk factors which are associated with coronary heart disease and other cardiovascular disease such as stroke in middle aged men from Northern Ireland. In 2014 the PRIME study was awarded a grant by the British Heart Foundation to allow it to continue and complete the 10 year follow-up to identify whether periodontal (gum) disease at baseline was associated with new (incident) coronary heart disease events. The Cognitive Follow-Up Study began 2016 and involves an ACE-R cognitive test, a small blood sample, height, weight, waist and upper arm circumference measurements, handgrip strength and questionnaires about diet, overall health and dental health. Cognition was assessed once previously by an MMSE completed at a re-screening completed between 2001-2004. " |
| #Subjects at Baseline |
2745 |
| Institution Name |
Queen's University Belfast, Institute of Clinical Sciences |
| Department Name |
Centre for Public Health |
| City |
Belfast |
| Study/Database Website |
http://www.qub.ac.uk/primestudy |
| Principal Investigator (PI) |
Professor Gerard Linden |
| Key Study References |
Please see Literature section |
| Population Based Study? |
Yes |
| Family Based Study? |
No |
| Clinical based sample? |
Yes |
| Is there follow-up data available? |
Yes |
| Were participants included prior to development of dementia (may refer to controls only)? |
Yes |
| Were participants included prior to development of MCI (may refer to controls only)? |
Yes |
| How is data collected? |
In person and postal: A Baseline screening in the early nineties (1991-1993). A Rescreen between 2001-2004. 9 follow up postal questionnaires over the course of the cohort study. |
| Who carries out data collection? |
Interviewers and clinical staff: Clerical staff collect questionnaire data. Research nurses staff collected physical data. |
| Does this take place in participants' homes or at a central location? |
Home and central: Study included both home visits and hospital visits. |
| Do participants take part individually or are families/partners involved? |
Individually |
| Dementia cases ascertained as part of study: |
Yes |
| Diagnosis based on review of existing clinical data |
Yes |
| Was diagnosis/primary outcomes made blind to exposure variables? |
Yes |
| How many times followed up? |
Depends on funding which has been sought for different aspects of follow-up. To date principal focus has been on cardiovascular endpoints.Recent funding has focused on cognition. |
| Study start date |
18/09/2017 00:00:00 |
| Is study ongoing? |
Yes |
| Is study still recruiting? |
No |
| Inclusion criteria |
Representative sample of 50-60 year-old men living in Belfast area, Northern Ireland in early 1990's |
| Exclusion criteria |
None |