| Cohort Name |
Viking Genes: ORCADES Study |
| Cohort Acronym |
ORCADES |
| Study Overview |
ORCADES is a cohort of volunteers with ancestry from the Orkney Islands, primarily for identifying genetic variants influencing disease. |
| #Subjects at Baseline |
ORCADES has 2,088 participants |
| Institution Name |
The University of Edinburgh |
| Department Name |
MRC Human Genetics Unit / Usher Institute |
| City |
Edinburgh |
| Study/Database Website |
www.ed.ac.uk/viking |
| Principal Investigator (PI) |
Prof James F. Wilson |
| Key Study References |
McQuillan R, Leutenegger AL, Abdel-Rahman R et al: Runs of homozygosity in European populations. Am J Hum Genet 2008; 83: 359-372 |
| Population Based Study? |
Yes |
| Family Based Study? |
Yes |
| Clinical based sample? |
No |
| Is there follow-up data available? |
Summary data from the EHR is available; consent was also given for recontact |
| Were participants included prior to development of dementia (may refer to controls only)? |
All participants were free of dementia (to the extent of being able to attend a clinic and complete a questionnaire) at recruitment |
| Were participants included prior to development of MCI (may refer to controls only)? |
As above, mild cognitive impairment is possible, but unlikely given the complexity of the recruitment process |
| How is data collected? |
From clinic measurements, a paper questionnaire, from the EHR; from measurements on serum and plasma samples; also genetic data from blood or saliva samples |
| Who carries out data collection? |
Recruitment is complete. The participants completed a detailed paper questionnaire and research nurses collected samples and made a wide range of measurements |
| Does this take place in participants' homes or at a central location? |
In both central and mobile locations in Orkney |
| Do participants take part individually or are families/partners involved? |
Individuals, their families and partners were all welcome to join the cohort if eligible |
| Dementia cases ascertained as part of study: |
Zero |
| How many times followed up? |
Zero |
| Study start date |
The year 2005 |
| Study end date |
The year 2011 |
| Is study ongoing? |
Yes |
| Is study still recruiting? |
No |
| Inclusion criteria |
Participant is aged 18 years or above, willing and able to give informed consent for participation and has at least two Orcadian grandparents |
| Exclusion criteria |
Lack of capacity to provide informed consent and attend clinics, or the lack of Northern Isles ancestry |