Cohort Descriptives

Variable Response
Cohort Name Viking Genes: ORCADES Study
Cohort Acronym ORCADES
Study Overview ORCADES is a cohort of volunteers with ancestry from the Orkney Islands, primarily for identifying genetic variants influencing disease.
#Subjects at Baseline ORCADES has 2,088 participants
Institution Name The University of Edinburgh
Department Name MRC Human Genetics Unit / Usher Institute
City Edinburgh
Study/Database Website

Principal Investigator (PI) Prof James F. Wilson
Key Study References

McQuillan R, Leutenegger AL, Abdel-Rahman R et al: Runs of homozygosity in European populations. Am J Hum Genet 2008; 83: 359-372

Population Based Study? Yes
Family Based Study? Yes
Clinical based sample? No
Is there follow-up data available? Summary data from the EHR is available; consent was also given for recontact
Were participants included prior to development of dementia (may refer to controls only)? All participants were free of dementia (to the extent of being able to attend a clinic and complete a questionnaire) at recruitment
Were participants included prior to development of MCI (may refer to controls only)? As above, mild cognitive impairment is possible, but unlikely given the complexity of the recruitment process
How is data collected? From clinic measurements, a paper questionnaire, from the EHR; from measurements on serum and plasma samples; also genetic data from blood or saliva samples
Who carries out data collection? Recruitment is complete. The participants completed a detailed paper questionnaire and research nurses collected samples and made a wide range of measurements
Does this take place in participants' homes or at a central location? In both central and mobile locations in Orkney
Do participants take part individually or are families/partners involved? Individuals, their families and partners were all welcome to join the cohort if eligible
Dementia cases ascertained as part of study: Zero
How many times followed up? Zero
Study start date The year 2005
Study end date The year 2011
Is study ongoing? Yes
Is study still recruiting? No
Inclusion criteria Participant is aged 18 years or above, willing and able to give informed consent for participation and has at least two Orcadian grandparents
Exclusion criteria Lack of capacity to provide informed consent and attend clinics, or the lack of Northern Isles ancestry