Cohort Descriptives

Variable Response
Cohort Name Oxford Parkinson's Disease Centre Discovery Cohort
Cohort Acronym OPDC Discovery
Study Overview Oxford Parkinson Disease Center (OPDC) was established in 2009 with funding from the Parkinson UK Monument Discovery Award and brings together world-leaders in clinical neurology, neuroepidemiology, neuroimaging, proteomics, genomics, molecular genetics, transgenic PD models, neuropharmacology, neurophysiology and neuropathology. The OPDC Discovery cohort is a prospective, longitudinal study that has recruited patients with early idiopathic Parkinson Disease, healthy controls and participants at risk of PD. The study also includes participants with REM Sleep Behaviour Disorder.
#Subjects at Baseline 1,082 PD, controls 297, 106 PD relatives, 104 RBD
Institution Name University of Oxford
Department Name Oxford Parkinson's Disease Centre
City Oxford
Study/Database Website

http://opdc.medsci.ox.ac.uk/home

Principal Investigator (PI) Dr Michele Hu
Key Study References

Please see Literature section

Population Based Study? No
Family Based Study? Yes
Clinical based sample? Yes
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? In person
Who carries out data collection? Clinicians
Does this take place in participants' homes or at a central location? Central
Do participants take part individually or are families/partners involved? Family
Dementia cases ascertained as part of study: No
Diagnosis based on review of existing clinical data No
Was diagnosis/primary outcomes made blind to exposure variables? Yes
Study start date 1/1/2009 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? Yes
Inclusion criteria Participant is willing and able to give informed consent for participation in the study. Should be fluent in English. Male or Female, aged 18 years or above. For patients: there must be a clear diagnosis of PD made by a Neurologist with expertise in this disease. No evidence of significant cognitive impairment For controls: must be age and sex strata matched. At-risk individuals will be first degree relatives of PD patients
Exclusion criteria The participant may not enter the study if ANY of the following apply: Inability to provide informed consent or withdrawal of consent at any stage. Medical or psychiatric illness that would interfere with completing initial or follow-up assessments Severe mental impairment due to dementia or psychosis Pregnancy Contraindication to lumbar puncture e.g. bleeding diathesis, epidural abscess, suspicion of raised intracranial pressure. Contraindication to MRI e.g. incompatible metal foreign body or suspicion of such. Contraindication to saccadometry e.g. double vision or serious eye disease

Administration

Variable type Variables generally collected
Study ID Y
Age Y
Sex Y

Sociodemographic

Variable type Variables generally collected
Age Y
Age at time of diagnosis of dementia Y
Age at last follow-up Y
Age at time of death Y
Sex Y
Ethnicity Y
Years of education Y
Employment status Y
Socioeconomic status measures Y

Physical Health Status

Variable type Variables generally collected
Cardiovascular disease data Y
Medication use for CVD Y
Hypertension Y
Systolic/Diastolic BP Y
Hypotension Y
Hypercholesterolemia Y
Olfactory sensitivity Y
Cancer Y
Stroke data Y
Stroke type Y
Transient Ischemic Attack Y

Healthcare Utilisation

Variable type Variables generally collected
Medication use Y
Medication use for CVD Y

Life Functionality

Variable type Variables generally collected
UPDRS (PD specific) Y
Hoehn and Yahr (PD specific) Y
Schwab and England (PD specific) Y

Psychological Status

Variable type Variables generally collected
Personality evaluation (Big Five Inventory of Personality) Y
REM sleep behaviour disorder questionnaire Y
Epworth Sleepiness Scale Y
Fatigue in PD Y
Objective sleep staging Y

Mental Health Status

Variable type Variables generally collected
Aggression scale Y
Beck Depression Inventory Y
NPI Y
Hospital Anxiety Depression Scale/Psychiatry (HADS) Y
Anxiety measure Y

Cognitive Status

Variable type Variables generally collected
Parkinson's Disease Y

Lifestyle

Variable type Variables generally collected
Smoking Y
Current smoking Y
Former smoking Y
Alcohol Y
Abstainers/former users Y

Physical Environment

Variable type Variables generally collected
Living situation Y

Physical Examination

Variable type Variables generally collected
Blood pressure (assessed before onset of dementia) Y
Weight (assessed before onset of dementia) Y
Height (assessed before onset of dementia) Y
Neurological examination (assessed before onset of dementia) Y
ECG (very small subgroup) (assessed before onset of dementia) Y
Respiratory examination (very small subgroup) (assessed before onset of dementia) Y
Spirometry (Very small subgroup) (assessed before onset of dementia) Y
Gait assessment (Freezing of Gait (FOG) Questionnaire) (assessed before onset of dementia) Y
Get Up and Go test (assessed before onset of dementia) Y
Opthalmic examination (assessed before onset of dementia) Y
Purdue Pegboard test Y
Flamingo Balance Test Y
Hand tapping/manual evoked reaction time task Y
Eye movement tracking (saccadometry) Y
BMI Y
Diet Y
Coffee and Caffeine Y

Digital Phenotyping

Variable type Variables generally collected
Language Y
IQ data Y
NART Y
IQ-CODE Short Questionnaire Y
MMSE Y
MoCA Y
EQ-5DVAS Y

Imaging

Variable type Variables generally collected
Structural T1 Y
Diffusion imaging (DTI/DWI) Y
f-MRI (rest) Y

Genomics

Variable type Variables generally collected
ExomeChip versions (Illumina HumanCoreExome-12 v1.1) Y
Exome/Genome sequencing broad platform categories (Illumina) Y
Gene Screening: MAPT Y

Metabolomics

Variable type Variables generally collected
CRP (Small subgroup for CRP-48) Y

Environmental Assessment

Variable type Variables generally collected
Mini Environmental Risk Questionnaire for PD Baseline (MERQ-PD B) Y