Cohort Descriptives

Variable Response
Cohort Name MRC National Survey of Health and Development
Cohort Acronym MRC NSHD
Study Overview The MRC National Survey of Health and Development (MRC NSHD) has informed UK healthcare, education and social policy for more than 70 years and is the oldest and longest running of British birth cohort studies. Today, with study members in their seventies, the NSHD offers a unique opportunity to explore the long-term biological and social processes of ageing and how ageing is affected by factors acting across the whole of life. From an initial maternity study of births recorded from England, Scotland and Wales during one week of March 1946, a socially stratified sample of singleton babies born to married parents was selected for follow-up. These participants have been studied over twenty times throughout their life. During their childhood, the main aim of the NSHD was to investigate how the environment at home and school affected physical and mental development and educational attainment. During adulthood, the main aim was to investigate how childhood health and development and lifetime social circumstances affected their adult health and function and their change with age. Now, as participants reach retirement, the research team is developing the NSHD into a life course study of ageing.
#Subjects at Baseline 5362
Institution Name University College London
Department Name MRC Unit for Lifelong Health and Ageing at UCL
City London
Study/Database Website

http://www.nshd.mrc.ac.uk/

Principal Investigator (PI) Nishi Chaturvedi
Key Study References

Please see Literature section

Population Based Study? Yes
Family Based Study? No
Clinical based sample? No
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? A combination of in person, postal and also in school.
Who carries out data collection? Interviewers: Health visitors in childhood interviewed mothers. Research nurses interviewed study members in adult life. School doctors and teachers assessed the study members in childhood.
Does this take place in participants' homes or at a central location? Home. Central: Mothers took children to school doctors and clinics. Study members were invited to Wellcome Trust Clinical Research Facilities from 2006-2010.
Do participants take part individually or are families/partners involved? Individually
Dementia cases ascertained as part of study: No
Diagnosis based on review of existing clinical data No
Was diagnosis/primary outcomes made blind to exposure variables?
How many times followed up? 24
# Subjects at Follow-up
Study start date 1/3/1946 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? No
Inclusion criteria Born in a specific week in March 1946.
Exclusion criteria Excluded births to unmarried mothers and excluded multiple births.

Administration

Variable type
Age At Interviews/Questionnaires
Date Of Form Completion
Date Of Interview/Health Visit
Interviews/Questionnaires Completed
Sex Of Cohort Member
Standard Region Where Cohort Member Lived

Sociodemographic

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
Deprivation Cars/vans owned/available to use in household                 Y
Deprivation Crowding   Y              
Deprivation Domestic help (occasional/regular)   Y              
Deprivation Ever lived/been abroad/emigrated           Y Y    
Deprivation Housing score   Y              
Deprivation How financially secure                 Y
Deprivation Income questions         Y   Y Y Y
Deprivation Moved house   Y         Y Y Y
Deprivation Ownership of house   Y     Y Y Y Y Y
Deprivation State of clothing   Y              
Deprivation Townsend index               Y  
Deprivation Valid driving licence               Y  
Deprivation Went without in last year because short of money           Y Y Y Y
Deprivation Where child normally plays   Y              
Education 11+ test   Y              
Education Absences   Y Y            
Education Application to Oxbridge     Y            
Education Class of degree       Y          
Education College/university     Y Y          
Education Details of education/schools went to   Y Y Y Y        
Education Exams     Y Y Y        
Education GCE 'O' levels   Y Y   Y        
Education Highest educational attainment/qualifications   Y Y Y Y Y Y    
Education Nursery   Y              
Education Parent Teacher Association   Y     Y        
Education Parents' interest in education   Y Y            
Education Post-graduate study     Y Y          
Education School careers advice   Y Y            
Education School facilities/faculty   Y Y            
Education Spouse's education/qualifications         Y Y      
Education Total A/H levels     Y Y Y        
Employment Apprenticeship/apprentice status     Y   Y        
Employment Attitude to work     Y Y Y Y Y Y  
Employment Changes in work life/difficulties at work         Y   Y Y  
Employment Earnings     Y   Y   Y Y  
Employment Employment details     Y Y Y Y Y Y Y
Employment Employment status/spouse's employment status     Y   Y Y Y Y Y
Employment Job advice received   Y Y            
Employment Job stability     Y            
Employment Overtime/paid holidays         Y Y Y    
Employment Pension scheme         Y       Y
Employment Promotion         Y Y Y    
Employment Retirement/spouse's retirement               Y Y
Employment Social class         Y   Y Y  
Employment Summer job     Y Y          
Employment Total number of jobs     Y Y Y Y Y Y Y
Employment Training course         Y Y      
Employment Unemployment         Y Y Y Y Y
Employment Whether has a second job               Y Y
Marital Status End of marriage           Y   Y  
Marital Status Marital status         Y Y Y Y Y
Marital Status Year of marriage/s       Y Y Y   Y Y
Religion Church attendance           Y      
Religion Parents' attitudes to religion   Y              
Religion Religious attitudes/belief   Y     Y Y      
Religion Religious denomination of school   Y              
Religion Religious upbringing         Y Y      
Religion Spouse's religious beliefs         Y Y      
Religion Type of Sunday school attended   Y              

Family History

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
Children Age at first child               Y  
Children Any children left home             Y Y  
Children Had any children       Y Y Y Y Y Y
Children More than 5 children             Y    
Children Serious difficulties with any of your children because of their health/behaviour             Y Y Y
Children Sex of children         Y Y Y Y  
Children Type of school children attended             Y    
Children Year of birth of children           Y   Y  
Extended Any family known to have tuberculosis   Y              
Extended Close female relatives have a hysterectomy             Y    
Extended Grandchildren             Y Y Y
Extended Numbers of uncles/aunts   Y              
Extended Year husband/wife died               Y Y
Father Age of father at death         Y Y Y Y Y
Father Father's cold history   Y              
Father Father's education/qualifications   Y     Y        
Father Father's job details Y Y     Y        
Father Father's medical history           Y Y    
Father Father's social class   Y              
Father Height/weight of survey child's father   Y              
Father Parental Bonding Instrument (PBI) Father's care scale             Y    
Father Parents ever been divorced/separated         Y        
Father PBI Father's overprotection scale             Y    
Gparents Grandfathers alive   Y              
Gparents Grandfathers' industry/occupation   Y              
Mother Age of mother at death         Y Y Y Y Y
Mother Mother's cold history   Y              
Mother Mother's education/qualifications   Y              
Mother Mother's height/weight   Y              
Mother Mother's job details   Y              
Mother Mother's medical history           Y Y    
Mother Mother's menstruation history   Y       Y Y    
Mother PBI Mother's care scale             Y    
Mother PBI mother's overprotection scale             Y    
Siblings Adult siblings   Y              
Siblings Difficulty with siblings   Y              
Siblings Natural dead siblings         Y        
Siblings Siblings' jobs/earnings   Y Y            
Siblings Step/half/adopted siblings         Y        

Early Life History

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
Birth Date of mother getting up after birth Y                
Birth Person in charge of confinement Y                
Birth Type of antenatal care Y                
Breastfed Breastfeeding   Y     Y        
Handedness Right/left handed   Y           Y Y
Childhood Environment Childhood milestones by two years old   Y              
Childhood Environment How old when toilet training trouble started   Y              
Childhood Environment Infant Welfare Centre attendance   Y              
Mother Smoked Either parent smoked when you were a child               Y  

Physical Health Status

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
Cancer Age at diagnosis of cancer           Y   Y  
Cancer Ever had cancer             Y Y Y
Cancer Moderate/severe cancer                 Y
Cardiothoracic Aneurysm                 Y
Cardiothoracic Angina           Y Y Y Y
Cardiothoracic Cardiomyopathy                 Y
Cardiothoracic Congenital heart disease   Y              
Cardiothoracic CVD                 Y
Cardiothoracic Heart attack/MI               Y Y
Cardiothoracic High cholesterol                 Y
Cardiothoracic Hypertension           Y Y Y Y
Cardiothoracic Other heart trouble/failure   Y       Y Y Y Y
Cardiothoracic Pulmonary/systemic embolism                 Y
Cardiothoracic Stroke           Y Y   Y
Endocrinology Hyperthyroidism                 Y
Endocrinology Thyroid problems/disorders   Y   Y Y Y Y Y Y
ENT Adenoidal symptoms   Y              
ENT Cold/hayfever symptoms   Y   Y Y Y Y Y  
ENT Discharging/pus from ears   Y              
ENT Ear drum/canal problems   Y             Y
ENT Hearing problems/deafness   Y         Y Y Y
ENT Noises in head/ears             Y    
ENT Number of times seen by dentist   Y             Y
ENT Pillars of fauces   Y              
ENT Tonsils   Y              
Eyes Astigmatism/squint   Y Y Y          
Eyes Cataracts/glaucoma/detached retina             Y Y Y
Eyes Eye dominance   Y              
Eyes Glasses/contact lenses   Y         Y Y  
Eyes Long/short-sighted     Y Y          
Eyes Other eye defects   Y   Y          
Eyes Sudden sight problems that got better after a day               Y Y
Eyes Visual/refractive errors/sight difficulty   Y         Y Y Y
Gastrointestinal Constipation/diarrhoea   Y         Y Y Y
Gastrointestinal Gall bladder trouble           Y Y Y  
Gastrointestinal Hernia/umbilical hernia   Y       Y Y    
Gastrointestinal Irritable bowel syndrome/bowel problems   Y         Y   Y
Gastrointestinal Other stomach trouble           Y Y Y Y
Gastrointestinal Piles/haemorrhoids             Y Y  
General Health Any accidents/injuries from accidents     Y Y Y   Y Y Y
General Health Broken bones/fractures               Y Y
General Health Cold/night sweats             Y Y  
General Health Cystitis               Y  
General Health Deep vein thrombosis                 Y
General Health Diabetes         Y Y Y Y Y
General Health Dizziness/unsteadiness           Y Y Y Y
General Health Gums/mouth trouble           Y Y Y Y
General Health Hair loss             Y Y  
General Health Health self-assessment           Y Y   Y
General Health Hernia/weakness of inguinal canal   Y              
General Health Illnesses in specific age periods Y Y Y Y Y        
General Health Incontinence/night wetting   Y         Y Y Y
General Health Jaundice   Y              
General Health Kidney/bladder infection           Y Y Y  
General Health Liver problems/disease             Y Y Y
General Health Measles/shingles/mumps   Y           Y  
General Health Meningitis/encephalitis               Y  
General Health Myalgic encephalomyelitis (ME)               Y  
General Health Orthopaedic defects   Y              
General Health Osteoporosis               Y Y
General Health Other health problems   Y       Y Y Y Y
General Health Physical health impacting daily life                 Y
General Health Pins and needles in hands and feet             Y Y  
General Health Scarlet fever   Y              
General Health Skin problems/eczema/psoriasis           Y Y Y Y
General Health Speech abnormalities/problems   Y             Y
General Health Varicose veins             Y    
General Health Vomiting/nausea   Y         Y Y  
General Health Whooping cough   Y              
Immunological Allergies             Y Y  
Immunological Lymphatic glands   Y              
Neurological Epilepsy/fits   Y       Y Y Y Y
Pain Aches and pains                 Y
Pain Bodily pain   Y     Y       Y
Pain Chest pain           Y Y Y Y
Pain Chronic pain                 Y
Pain Headaches/migraines         Y Y Y Y  
Pain Leg/joint pain             Y Y Y
Pain Sciatica/lumbago/backache         Y Y Y Y Y
Pain SF-36 pain index                 Y
Reproductive Abnormality of the external genital organs   Y              
Reproductive Axillary/pubic hair at 11/15   Y              
Reproductive Genital prolapse             Y    
Reproductive Whether been sterilised             Y    
Respiratory Asthma   Y       Y Y Y Y
Respiratory Breathing with mouth open   Y              
Respiratory Bronchitis/pneumonia   Y   Y Y Y Y Y Y
Respiratory Chest ever wheezy or whistling       Y Y Y Y Y Y
Respiratory Chest illness         Y Y Y Y Y
Respiratory Collapsed/punctured/blood clot in lung/coughing up blood       Y Y       Y
Respiratory Respiratory disease                 Y
Respiratory Shortness of breath       Y Y       Y
Rheumatology Arthritis/rheumatism         Y Y Y    
Rheumatology Osteoarthritis               Y Y
Rheumatology Rheumatic disease   Y              

Reproductive History

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
Female Anaestheisa for first birth   Y              
Female Breast development   Y              
Female Breast fed children             Y    
Female Breast lumps               Y  
Female Breast tenderness             Y Y  
Female Caesarean delivery for any children             Y    
Female Contraception method         Y Y Y Y  
Female Difficulties with intercourse             Y Y  
Female Endometriosis             Y    
Female Ever had stillbirth/miscarriage             Y    
Female Extensive Hormone Replacement Therapy (HRT) questions             Y Y Y
Female Have not had sexual intercourse with a man             Y    
Female Hot flushes             Y Y  
Female Hysterectomy             Y Y  
Female Last cervical smear             Y    
Female Lining of womb removed (endometrial ablation)             Y    
Female Mammograms               Y  
Female Menopause             Y Y Y
Female Ovarian cysts/uterine fibroids             Y    
Female Pelvic inflammatory disease             Y    
Female Pelvic/lower abdominal pain             Y    
Female Postnatal depression             Y    
Female Pregnant       Y Y Y Y Y  
Female Puberty   Y              
Female Status of menstruation   Y         Y Y Y
Female Suffered from pre-menstrual tension/syndrome symptoms             Y    
Female Unwanted body hair             Y    
Female Vaginal dryness             Y Y  
Male Age of circumcision   Y              
Male Broken voice   Y              
Male Genetalia at 15   Y              
Male Puberty   Y              
Male Testes   Y              

Healthcare Utilisation

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
Hospitalisation Been admitted to hospital for chest pain/angina/heart attack                 Y
Hospitalisation Been admitted to hospital for heart complaint/stroke               Y Y
Hospitalisation Date of admission/discharge from hospital           Y Y Y Y
Hospitalisation Hospital in-patient     Y Y Y   Y Y Y
Hospitalisation Nature of treatment at hospital         Y       Y
Hospitalisation Out-patient attendances       Y Y   Y    
Medications Anticancer drugs                 Y
Medications Antihistamines                 Y
Medications Antileprotic drugs                 Y
Medications Antimalarials                 Y
Medications Antiparasitic drugs                 Y
Medications Antipsychotics/antimanics                 Y
Medications Anti-rheumatic/arthritic medication                 Y
Medications Antivirals/antibiotics/antifungals                 Y
Medications Anxiolytics/antidepressants         Y Y Y Y Y
Medications Appetite suppressants/anti-obesity drugs                 Y
Medications Bisphosphates                 Y
Medications Central nervous system medication               Y  
Medications Cold medication                 Y
Medications Dementia medication                 Y
Medications Diabetes medication               Y Y
Medications Drugs for erectile dysfunction                 Y
Medications Drugs for urinary retention                 Y
Medications Epilepsy medication               Y Y
Medications Eye medication                 Y
Medications Laxatives/antimotility drugs   Y             Y
Medications Lipid-lowering medication               Y  
Medications Medication for ADHD                 Y
Medications Medication for cardiothoracic problems         Y     Y Y
Medications Medication for gastrointestinal problems                 Y
Medications Medication for nausea/vertigo               Y  
Medications Medication for oral problems             Y   Y
Medications Medication for respiratory problems   Y           Y Y
Medications Medication for skin problems                 Y
Medications Medication for TB                 Y
Medications Non-opioid analgesics/NSAIDs               Y Y
Medications Parkinsonism drugs                 Y
Medications Prescibed medicines             Y Y  
Medications Sex hormones/hormone antagonists               Y Y
Medications Skeletal muscle relaxants/antispasmodics                 Y
Medications Thyroid medication                 Y
Medications Treatment for measles   Y              
Medications Vaccinations/immunisations   Y             Y
Surgery Abdominal/chest surgery in last 3 weeks               Y Y
Surgery Angioplasty                 Y
Surgery Coronary artery bypass graft (CABG)                 Y
Surgery Ear/eye surgery                 Y
Surgery Joint replacement                 Y
Surgery Loss of limb           Y      
Surgery Operation to remove uterus and/or ovaries             Y Y Y
Surgery Removal of tonsils/adenoids   Y              

Life Functionality

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
Assistive Devices Hearing aid   Y             Y
Assistive Devices Mobility aids                 Y
Assistive Devices Pacemaker                 Y
Daily Living Difficulty/needed help with IADL                 Y
Daily Living Needed help with ADL tasks                 Y

Psychological Status

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
Personality Agreeableness/conscientiousness questions                 Y
Personality Attention/concentration/alertness   Y             Y
Personality Attitude to work/hard working   Y Y Y          
Personality Bossy/dominating           Y      
Personality Competitiveness/hard-driving   Y       Y      
Personality Cribbing (copying others' work)   Y              
Personality Energetic/energy levels   Y     Y        
Personality Externalising/internalising   Y              
Personality Extroversion   Y Y   Y       Y
Personality Frequently lost in thought even during conversation/daydreaming   Y     Y        
Personality Habit behaviours   Y              
Personality Inclined to be moody         Y        
Personality Maudsley Personality Inventory   Y Y Y          
Personality Personality evaluation   Y              
Personality Prefer action to planning for action         Y        
Personality Things like/dislike about getting older                 Y
Personality Truancy   Y              
Quality Of Life Difficulty/level of confidence doing everyday tasks             Y Y Y
Sleep Can't sleep from ideas running through head   Y              
Sleep Lack of energy/tiredness             Y Y  
Sleep Nightmares/disturbed sleep   Y              
Sleep Pittsburgh Sleep Quality Index (PSQI)                 Y
Sleep Self-reported exhaustion                 Y
Sleep Sleep with windows open       Y Y        
Sleep Snoring   Y              
Sleep Time taken to fall asleep                 Y
Sleep Trouble sleeping/sleep complaints     Y   Y   Y Y Y
Sleep What time usually go to bed/get up in morning   Y             Y
Wellbeing Anything about job/life in general which causes you a lot of worry     Y            
Wellbeing Can you get around indoors without aids or personal help                 Y
Wellbeing Changes in abilities/everyday decisions             Y Y  
Wellbeing Changes in self-confidence             Y Y  
Wellbeing Confidence in own opinions/decisions               Y  
Wellbeing Diener Satisfaction With Life Scale                 Y
Wellbeing Emotional demands looking after house/children           Y      
Wellbeing Feel confident and positive about self               Y  
Wellbeing Forgetfulness             Y Y  
Wellbeing How you feel about your body/looks             Y Y  
Wellbeing How happy         Y        
Wellbeing How long since last holiday           Y      
Wellbeing Opinion on future/dealing with life problems                 Y
Wellbeing Opinion on life/the world             Y Y  
Wellbeing Perception of self               Y  
Wellbeing Problems with remembering things                 Y
Wellbeing Psychiatric problems                 Y
Wellbeing Stammering   Y              
Wellbeing Under strain at home         Y        
Wellbeing Unused talents/skills           Y      
Wellbeing Usually pressed for time           Y      
Wellbeing Warwick Edinburgh Mental Wellbeing Scale               Y Y

Mental Health Status

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
Disorders Anorexia nervosa/bulimia nervosa/other eating disorder               Y  
Disorders Delirium                 Y
Disorders Nail biting/thumb/finger sucking   Y              
Disorders Obsessions   Y              
Mood Anxiety/anxious behaviour   Y         Y Y  
Mood Changes in mood   Y     Y        
Mood Depression         Y Y Y Y Y
Mood Emotional problems interfering with life                 Y
Mood Everything is an effort/can't get going                 Y
Mood Feelings of panic             Y Y  
Mood General Health Questionnaire (GHQ)               Y Y
Mood Happiness   Y     Y        
Mood Have you been a happy person                 Y
Mood How have you been feeling                 Y
Mood How often do you feel full of life                 Y
Mood How often do you have a lot of energy/feel worn out/tired                 Y
Mood Irritability             Y Y  
Mood Nervous/emotional trouble         Y Y Y Y Y
Mood Neuroticism   Y Y   Y        
Mood Patient Satisfaction Questionnaire (PSQ)               Y  
Mood Present State Examination (PSE)           Y Y    
Mood SF-36 mental health index                 Y
Mood Sometimes happy sometimes depressed for no reason         Y        
Mood Tearfulness             Y Y  

Cognitive Status

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
Parkinson's Parkinson's disease                 Y
Self Report Cognitive Status Any memory problems                 Y
Self Report Cognitive Status Feel like you have more memory difficulties than others                 Y

Lifestyle

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
Alcohol Average alcohol intake           Y Y Y Y
Alcohol Beer/lager/cider/stout             Y Y Y
Alcohol Drinking habits                 Y
Alcohol Ever felt bad/guilty about/ought to cut down drinking             Y Y Y
Alcohol People annoyed you by criticising your drinking             Y Y Y
Alcohol Spirits/liqueurs             Y Y Y
Alcohol Wine/sherry/martini/port             Y Y Y
Diet Average calorie intake           Y Y Y Y
Diet Carbohydrate intake   Y       Y Y Y Y
Diet Dairy intake   Y             Y
Diet Dieting/questions about diet/change in eating habits   Y     Y Y Y Y Y
Diet Difficulty eating/drinking without help             Y    
Diet Eats too quickly           Y      
Diet Fat/fatty acids           Y Y Y Y
Diet Fruit and veg intake   Y           Y Y
Diet Herbal supplements               Y  
Diet Hot/cold drink intake   Y           Y Y
Diet Loss of appetite             Y Y Y
Diet Nuts/seeds/pulses/lentils                 Y
Diet Protein (meat/fish/eggs) intake   Y           Y Y
Diet Salt intake         Y       Y
Diet Soup/sauces/preserves   Y             Y
Diet Strawbridge Frailty domain 2: nutritive functioning                 Y
Diet Sweet/savoury snacks   Y           Y Y
Diet Usually eat main meal alone/where normally eats main meal                 Y
Diet Vegetarian           Y Y Y  
Diet Vitamins and minerals   Y       Y Y Y Y
Digital Technology Time spent using computer                 Y
Digital Technology Time spent watching TV                 Y
Leisure Activities out of school in which shows exceptional ability   Y              
Leisure Average time spent reading                 Y
Leisure Church-related activities           Y Y   Y
Leisure Contribution to community life of school (teacher's opinion)     Y            
Leisure Evening classes/adult education     Y Y Y Y Y    
Leisure Hobbies/interests   Y Y       Y Y  
Leisure How often do you take part in/run playgroup/nursery             Y    
Leisure Local government activities         Y   Y    
Leisure Political parties/voting in general elections         Y        
Leisure Social activities   Y Y   Y Y Y   Y
Leisure Spare time activities     Y     Y Y Y  
Leisure Trade union activities             Y    
Leisure Voluntary services/activities           Y Y   Y
Physical Ball sports         Y Y     Y
Physical Bowling/bowls           Y     Y
Physical Conditioning/load-bearing exercises                 Y
Physical Cycling         Y Y Y   Y
Physical DIY           Y Y   Y
Physical Gardening     Y     Y Y   Y
Physical Gym exercise/weight training           Y     Y
Physical Hill/mountain climbing           Y     Y
Physical Horse-riding                 Y
Physical Ice-skating                 Y
Physical Martial arts                 Y
Physical Other physical activities           Y   Y Y
Physical Physical activity done for 30/60 minutes                 Y
Physical Physical demands looking after house/children           Y      
Physical Physical fatigue level after various activities                 Y
Physical Racket sports           Y     Y
Physical Running/jogging/walking           Y     Y
Physical Skiing                 Y
Physical Sports and recreation   Y       Y Y Y  
Physical Tai chi/yoga/pilates           Y     Y
Physical Time spent cleaning the house/housework             Y   Y
Physical Water sports (rowing/sailing/swimming)         Y Y     Y
Sexual Changes in sex life             Y Y  
Smoking Age when started smoking       Y Y       Y
Smoking Amount of pipe tobacco smoked       Y   Y   Y  
Smoking Carbon monoxide/tar levels of cigarettes smoked           Y      
Smoking How long ago stopped smoking       Y Y Y Y   Y
Smoking How many cigarettes do people you live with smoke               Y  
Smoking Smoke cigarettes/cigars       Y Y Y Y Y Y
Smoking Smoking habits/status       Y Y Y Y Y Y
Travel Average commuting distance                 Y
Travel Car or van normally available for you to use               Y  
Travel Time spent driving for work           Y      
Travel Use a bike to get to work           Y     Y

Physical Environment

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
Housing Adequate sanitation   Y              
Housing Adults in family   Y              
Housing Age of buildings     Y            
Housing Age of other household members           Y      
Housing Bathroom/kitchen/living rooms in household   Y     Y Y      
Housing Bedrooms/sleeping arrangements   Y         Y    
Housing Composite housing   Y              
Housing Enjoy being at home           Y      
Housing Happiness with accommodation/present district           Y Y    
Housing Heat at night/method of heating       Y Y   Y    
Housing Hot water   Y     Y        
Housing Is any part of accommodation damp             Y    
Housing Lack of home amenities/facilities   Y              
Housing Moved house in the past year               Y  
Housing Number of people in household   Y     Y Y Y Y Y
Housing Parent/parent-in-law/elderly relative lives with you             Y Y  
Housing Problems with/adequacy of accommodation         Y   Y    
Housing Share a bed/room   Y              
Housing Spouse/partner living in household             Y Y Y
Housing State/repair of the dwelling   Y              
Housing Type of house/dwelling/accommodation   Y     Y Y Y    
Housing Yard or garden   Y              
Work Cause/effect of strain/stress at work         Y        
Work Climbing ladders/stairs at work                 Y
Work Crises/disappointments at work               Y  
Work Ever worked in noisy places where needed to shout to be heard             Y    
Work How long worked in noisy environment             Y    
Work How often find work stressful               Y  
Work Is job dangerous in any way             Y    
Work Night shifts         Y        
Work Physical demands from work           Y Y   Y
Work Place of work           Y Y    
Work Sickness absences/time off from work     Y Y Y        
Work Skill and judgement used in job         Y        
Work Use of machinery         Y        
Work Walking at work                 Y
Work Work accidents     Y            
Work Work in dusty conditions             Y    

Social Environment

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
Life Events Any crises in own family/others close to you           Y Y Y Y
Life Events Any serious upsets/disappointments/bad news           Y Y Y Y
Life Events Fallen out/had serious disagreement with friend             Y Y  
Life Events Have you been assaulted/robbed/burgled           Y Y Y  
Life Events Ill parents   Y              
Life Events Relation/friend been injured           Y      
Life Events Relation/friend been separated/divorced           Y      
Life Events Relation/friend died recently           Y Y Y Y
Life Events Relation/friend gone into hospital/had a serious illness           Y Y Y Y
Social Care (Given) Look after anyone sick/elderly                 Y
Social Care (Given) Time spent caring for children/elderly/disabled                 Y
Social Interaction Antisocial behaviour   Y              
Social Interaction Any relation/friend been a worry to you           Y      
Social Interaction Close person to confide in/talk to             Y Y Y
Social Interaction Enough opportunity to talk openly and share your feelings             Y   Y
Social Interaction Friends/neighbours/relatives who would help with problem/crisis             Y Y Y
Social Interaction Friendships/associations in neighbourhood                 Y
Social Interaction How often do you help/see/contact parents           Y Y    
Social Interaction How often feel left out                 Y
Social Interaction How often meet friends/relatives socially             Y Y Y
Social Interaction Know you can trust your friends, and they can trust you               Y  
Social Interaction Lost contact with a close friend/relative             Y Y Y
Social Interaction Not many people who want to listen when you want to talk               Y  
Social Interaction Often feel lonely because you have few close friends to share concerns with               Y  
Social Interaction Serious disagreements with spouse/partner             Y   Y
Social Interaction Share interests/hobbies/fun with closest person               Y Y
Social Interaction Take initiative on making new friends         Y        
Social Interaction Who spoke to about personal problems     Y Y          
Socialmedia How often taken part in online social networking                 Y

Physical Examination

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
Anthropometry Abdominal aortic calcification                 Y
Anthropometry Activity monitor                 Y
Anthropometry Area for femoral neck/spine/total hip                 Y
Anthropometry Body Mass Index (BMI)                 Y
Anthropometry Buckling ratio                 Y
Anthropometry Circumference of various body parts           Y Y Y Y
Anthropometry Cortical thickness                 Y
Anthropometry Hand examination               Y  
Anthropometry Height/weight of spouse         Y        
Anthropometry Hip/spine morphology               Y Y
Anthropometry Kellgren-Lawrence Grade               Y Y
Anthropometry Lean mass/height squared                 Y
Anthropometry Lumbar/thoracic vertebrae lane grade score               Y Y
Anthropometry Medullary area                 Y
Anthropometry Muscle density                 Y
Anthropometry Physique   Y              
Anthropometry Polar stress strain index                 Y
Anthropometry Standing/sitting height   Y   Y Y Y Y Y Y
Anthropometry Strawbridge Frailty domain 1: physical functioning                 Y
Anthropometry Super-Imposition by Translation And Rotation (SITAR)   Y              
Anthropometry Triceps skinfold         Y        
Anthropometry Various body part/fat measurements                 Y
Anthropometry Waist-hip ratio             Y Y Y
Anthropometry Weight Y Y   Y Y Y Y Y Y
Ear Difficulty following conversation with backgroud noise             Y    
Ear Doctor's assessment of hearing   Y              
Eye Snellen tests for visual acuity   Y              
Heart Angiogram                 Y
Heart Blood pressure         Y Y Y Y Y
Heart Difficulties in taking blood samples               Y Y
Heart ECG                 Y
Heart Heart rate variability (HRV)                  
Heart Intima-media thickness                 Y
Heart Murmurs (standing/lying)   Y              
Heart Pulse/heart rate   Y       Y Y Y Y
Lung Lung function test             Y Y Y
Lung Peak expiratory flow           Y      
Mobility Balance/coordination problems             Y Y Y
Mobility Chair rises/stands             Y Y Y
Mobility Finger tapping test                 Y
Mobility Picking up objects   Y         Y    
Mobility Tapping right/left foot   Y              
Mobility Threading needle with right/left hand   Y              
Mobility Walking speed TUG               Y Y
Sensory Skin-crawling sensations             Y Y  
Sensory Strawbridge Frailty domain 4: sensory functioning                 Y
Strength Grip strength               Y Y
Strength Sudden weakness in arm/leg that got better after a day                 Y

Linkage Data

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
HES Currently registered with a GP               Y  
HES NHS or private patient             Y Y Y
HES Out-patient attendance   Y Y Y Y        
HES Student health service at university     Y            
HES Visits to doctor     Y Y     Y Y Y

Biosample Assays

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
Biochemistry Saliva sample                 Y
Biochemistry Urate                 Y
Biochemistry Urea                 Y
Biochemistry Urine assays/glucose/ketones                 Y
Haematology Albumin                 Y
Haematology Anticoagulents                 Y
Haematology Bilirubin                 Y
Haematology Biomarkers                 Y
Haematology Calcium                 Y
Haematology Cholesterol         Y       Y
Haematology Cortisol                 Y
Haematology Creatinine                 Y
Haematology Enzymes in blood                 Y
Haematology Free T3/T4                 Y
Haematology Globulin                 Y
Haematology Haematocrit                 Y
Haematology Haemoglobin/HbA1c                 Y
Haematology Insulin                 Y
Haematology Insulin-like growth factor                 Y
Haematology Iron                 Y
Haematology Lipoproteins (high density/low density)                 Y
Haematology Phosphate                 Y
Haematology Plasma glucose                 Y
Haematology Plasma sex hormone-binding globulin                 Y
Haematology Plasma steroids                 Y
Haematology Platelets                 Y
Haematology Potassium                 Y
Haematology Red blood cells                 Y
Haematology Red cell folate                 Y
Haematology Sodium                 Y
Haematology Thyroid stimulating hormone                 Y
Haematology Triglyceride         Y       Y
Haematology Vitamin C                 Y
Haematology White blood cells                 Y

Digital Phenotyping

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
Cognitive Performance Addenbrooke's Cognitive Examination (ACE III) test                 Y
Cognitive Performance Animal test               Y  
Cognitive Performance Cancellation Speed trials             Y    
Cognitive Performance Envelope test               Y  
Cognitive Performance National Adult Reading Test (NART)             Y    
Cognitive Performance Peg-board test             Y    
Cognitive Performance Picture memory test             Y    
Cognitive Performance Reaction time test                 Y
Cognitive Performance Reading test         Y        
Cognitive Performance Serial list memory task             Y Y Y
Cognitive Performance Strawbridge Frailty domain 3: cognitive functioning                 Y
Cognitive Performance Visual search test             Y Y Y
Cognitive Performance Whether remembered that body measurements were made             Y    

Imaging

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
BMD Bone mineral density                 Y
Echo Aorta measurements                 Y
Echo Heart measurements                 Y

Genomics

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
Genotyping Extensive genotyping from buccal/blood sample               Y  
Genotyping Extensive single nucleotide variation               Y  
Genotyping Microsatellite variation               Y  
Genotyping Telomere data               Y Y

Built Environment

Sub-category Variable type Baseline Wave 1 (Childhood) Wave 2 (age 16-18) Wave 3 (age 19-21) Wave 4 (age 22-31) Wave 5 (age 32-41) Wave 6 (age 42-51) Wave 7 (age 52-61) Wave 8 (age 62-71)
Air Pollution Pollution index Y Y              
Air Pollution Smoke pollution         Y        
Air Pollution Sulfur dioxide pollution         Y        
Air Pollution Within 50m of a class 1 or 2 type road/within 100m of a class 0 road (motorway)               Y Y
Morphometrics Catchment area (rural/suburban/urban)   Y Y            
Morphometrics Size of population where study member lives Y Y Y Y Y        
Morphometrics Size of town/type of distict Y Y Y