Cohort Descriptives

Variable Response
Cohort Name MRC National Survey of Health & Development
Cohort Acronym MRC NSHD
Study Overview The MRC National Survey of Health and Development (MRC NSHD) has informed UK health care, education and social policy for more than 50 years and is the oldest and longest running of the British birth cohort studies. Today, with study members in their seventies, the NSHD offers a unique opportunity to explore the long-term biological and social processes of ageing and how ageing is affected by factors acting across the whole of life. From an initial maternity survey of births recorded in England, Scotland and Wales during one week of March, 1946, a socially stratified sample of singleton babies born to married parents was selected for follow-up. These participants have been studied over twenty times throughout their life. During their childhood, the main aim of the NSHD was to investigate how the environment at home and at school affected physical and mental development and educational attainment. During adulthood, the main aim was to investigate how childhood health and development and lifetime social circumstances affected their adult health and function and their change with age. Now, as participants reach retirement, the research team is developing the NSHD into a life course study of ageing. Study members were asked to attend a clinic at age 60-64 for a range of assessments (or alternatively have a home visit).. They were invited for a home visit at 69 years , updating information on health, lifestyle and life circumstances as well as obtaining repeat physical and cognitive measurements. Postal questionnaires were completed before the clinic and home visits. A subset of 500 study members are also being invited to participate in a Neuroscience sub-study. Please note, alternatively, NSHD may be called the '1946 British birth cohort study' once the full name has been used first in any article.
#Subjects at Baseline 5362
Institution Name University College London
Department Name MRC Unit for Lifelong Health and Ageing at UCL
City London
Study/Database Website

http://www.nshd.mrc.ac.uk/

Principal Investigator (PI) Nishi Chaturvedi
Key Study References

Please see Literature section

Population Based Study? Yes
Family Based Study? No
Clinical based sample? No
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? A combination of in person, postal and also in school.
Who carries out data collection? Interviewers: Health visitors in childhood interviewed mothers. Research nurses interviewed study members in adult life. School doctors and teachers assessed the study members in childhood.
Does this take place in participants' homes or at a central location? Home. Central: Mothers took children to school doctors and clinics. Study members were invited to Wellcome Trust Clinical Research Facilities from 2006-2010.
Do participants take part individually or are families/partners involved? Individually
Dementia cases ascertained as part of study: No
Diagnosis based on review of existing clinical data No
How many times followed up? 23
Study start date 3/1/1946 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? No
Inclusion criteria Born in a specified week in March 1946.
Exclusion criteria Excluded births to unmarried mothers and excluded multiple births.

Administration

Variable type Variables generally collected
Study ID Y
Age Y
Sex Y

Sociodemographic

Variable type Variables generally collected
Age Y
Age at time of death Y
Sex Y
Ethnicity Y
Years of education Y
Level of education Y
Parental education Y
Employment status Y
Socioeconomic status measures Y

Physical Health Status

Variable type Variables generally collected
Cardiovascular disease (Subgroup) Y
Vascular structure and function Y
Carotid intima-medial thickness (IMT) Y
Arterial distensibility Y
Carotid/femoral pulse wave velocity Y
Central blood pressure and pulse wave analysis Y
Cardiac structure and function: echocardiography Y
Images from parasternal long axis and short axis views Y
Aortic views Y
Brachial blood pressure Y
Echography Y
Myocardial infarction Y
Medication use for CVD Y
Hypertension Y
Systolic/diastolic BP Y
Mean arterial pressure Y
Hypotension Y
Hypercholesterolemia Y
Cancer Y
Diabetic Status Y
Stroke data Y
Stroke type Y
Transient Ischemic Attack Y
Carotid Plaques Y
Head trauma data Y
Loss of consciousness Y
Head trauma severity Y

Healthcare Utilisation

Variable type Variables generally collected
Medication use (Drug Coding System) Y
Medication use for CVD Y
Hospital utilisation Y
Admission to nursing home Y
Home care- domestic Y
Informal ADL care Y
Informal iADL care Y

Life Functionality

Variable type Variables generally collected
Complex Activities of Daily Living, UPDRS (PD specific) (Subgroup) Y
Hoehn and Yahr (PD specific) (Subgroup) Y
Schwab and England (PD specific) (Subgroup) Y
ADL and iADL scales; non-dementia specific Y

Psychological Status

Variable type Variables generally collected
General Health Questionnaire done several times (GHQ) Y
GHQ28 Y
Life events Y
Edinburgh Wellbeing Scale Y
Life satisfaction Y
Spare time activities Y
Time spent caring for others Y
Personality evaluation Y
Teacher rated behaviour in adolescence Y
MPI at 16 years Y
Sleep assessment questionnaires Y
Actigraphy to measure sleep patterns Y

Cognitive Status

Variable type Variables generally collected
Dementia diagnosis Y
Subjective complaint Y

Lifestyle

Variable type Variables generally collected
Smoking Y
Pack years Y
Current smoking Y
Former smoking Y
Alcohol Y
Dietary and alcohol assessment (5-day diary) Y
Units per day/week vs weekend Y
Specified beverage type (wine, spirits, beers) Y
Abstainers/former users Y
Alcohol Use Disorders Identification Test (AUDIT) Y
CAGE questionnaire Y
Binge drinking Y
Physical activity and exercise Y
Type of exercise: heavy,light Y
Exercise duration Y
Objective measures of activity Y
Objective measure of fitness (VO2) Y
Incremental sleep test Y
Physical activity assessment (EPAQ2) Y
Diet: Carbs, protein, fats, fish oil Y
Anti-oxidants Y
Vegetarian? Y
Shortage of food Y
Coffee and Caffeine Y
Vitamin A,B,E Y
Fat intake MUFA,PUFA Y
Food questionnaires and other dietary items Y

Physical Environment

Variable type Variables generally collected
Living situation Y

Social Environment

Variable type Variables generally collected
The Close Persons Questionnaire Y
Neighbourhood satisfaction Y

Physical Examination

Variable type Variables generally collected
Blood pressure Y
Weight Y
Height Y
Neurological examination Y
Extrapyramidal symptoms Y
Heart Rate (Heart rate response to incremental step test) Y
Anthropometry Y
ECG Y
Cardiovascular examination Y
Vascular structure and function Y
Carotid intima-medial thickness (IMT) Y
Arterial distensibility Y
Carotid/femoral pulse wave velocity Y
Central blood pressure Y
Pulse wave analysis Y
Cardiac structure and function Y
Echocardiography Y
Images from parasternal long axis and short axis views Y
Aortic views Y
Brachial blood pressure Y
Specific assessment of peripheral vascular disease Y
Respiratory examination Y
PEFR Y
Spirometry Y
Gait assessment Y
Acuity (in childhood) Y
Colour vision Y
DXA Y
Hip assessment Y
Lumbar spine Y
Whole body region BMD Y
Fat and lean mass Y
Vertebral fracture assessment Y
Aortic calcification score Y
pQCT Y
Cortical CS area and thickness Y
BMC and BMD Y
CS muscle and fat area Y
Stress strain index Y
Moment of inertia Y
Grip strength Y
Chair rises Y
Get up and go test Y
Chest, upper arm, waist and hip circumference Y
Rose angina Scale Y
Intermittent claudication Y
Bronchitis Y
Osteoarthritis symptoms Y
Back pain Y
Knee injuries Y
Fracture history Y
BMI Y
Fat percentage Y
Blood lipids Y
Metabolic syndrome Y

Biosample Assays

Variable type Variables generally collected
Plasma Y
Serum Y
RNA Y
DNA Y
Urine (subgroup) Y
Saliva (Subgroup) (Repeated collection) Y

Digital Phenotyping

Variable type Variables generally collected
Visual Memory Y
Judgement Y
Verbal Memory Y
Logical Memory Y
Visuospatial Function Y
Attention Y
Reaction time Y
Language Y
Verbal fluency Y
Vigilance Y
Latent Memory Y
Motor speed and praxis Y
Prospective memory Y
IQ data Y
NART Y
MMSE (Subgroup) Y
Addenbrooke's Cognitive Exam Y

Imaging

Variable type Variables generally collected
Structural T1 Y
Fluid attenuation inversion recovery (FLAIR) Y
Diffusion imaging (DTI/DWI) Y
PET Y
Carotid artery scanning ultrasound Y
Cardio echo 2D Y

Genomics

Variable type Variables generally collected
GWAS Y
APOE gene screening Y

Metabolomics

Variable type