Cohort Descriptives

Variable Response
Cohort Name Cognitive Function and Ageing Study
Cohort Acronym MRC CFAS
Study Overview MRC CFAS started in the late 1980s with the initial aim of investigating dementia and cognitive decline in a representative sample of people aged over 65 years. To date there have been in the region of 47,000 interviews with participants in the study. The range of information collected has also allowed the study to investigate depression and physical disability in the older population and also look at healthy active life expectancy. Following baseline interviews, subsets of the cohort have been contacted for 1, 2, 6 and 8 year follow up and the whole sample were contacted for a 10 year follow up. There have also been 500 donations of participant’s brains after death. The aims of the study have evolved over its existence and cover a wide range including descriptive epidemiology, neuropathology, policy, molecular epidemiology, and ethics.
#Subjects at Baseline 18005
Institution Name University of Cambridge
Department Name Institute of Public Health
City Cambridge
Study/Database Website

https://www.cfas.ac.uk

Principal Investigator (PI) Prof Carol Brayne
Key Study References

Please see Literature Section

Population Based Study? Yes
Family Based Study? No
Clinical based sample? No
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? In person
Who carries out data collection? Interviewers: Mainly research interviewers, although a number of research nurses have taken blood.
Does this take place in participants' homes or at a central location? Home and Central
Do participants take part individually or are families/partners involved? Interviewers: Mainly research interviewers, although a number of research nurses have taken b+B33lood.
Dementia cases ascertained as part of study: Yes
Diagnosis based on review of existing clinical data No
How many times followed up? 6
How regular is follow-up? Every 2-3 years: Some had 6 or more Waves of interview. Brain donation participants are interviewed every 2-3 years. Less often: A subset were seen only at baseline, incidence screen (2-3 years later) and then 10 years later.
Study start date 1/1/1989 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? No
Inclusion criteria 65 years and over, speaks English proficiently. Lives in the cohort catchment area.
Exclusion criteria Anyone not proficient in English would be excluded from the sample.

Administration

Variable type Variables generally collected
Study ID Y
Age Y
Sex Y

Sociodemographic

Variable type Variables generally collected
Age Y
Age at time of diagnosis of dementia Y
Age at last follow-up Y
Age at time of death Y
Sex Y
Ethnicity Y
Years of education Y
Level of education Y
Employment status Y
Socioeconomic status Y

Physical Health Status

Variable type Variables generally collected
Cardiovascular disease Y
Medication use for CVD Y
Cancer Y
Diabetic Status Y
Stroke data Y
Stroke type Y
Head trauma data Y
Loss of consciousness Y

Health Care Utilisation

Variable type Variables generally collected
Medication use Y
Medication use for CVD Y
Interviews about care giving Y
Presciption Medicine cost Y
Admission to nursing home Y
Admission to home care Y
Day care at nursing home Y
Day care at home for elderly Y
Home care-domestic Y
Home care-personal care Y
Permanent stay at nursing home Y
Informal ADL care Y
Informal iADL care. Y

Life Functionality

Variable type Variables generally collected
Basic activities of daily living (BADL) Y
Instrumental activities of daily living (IADL) Y

Psychological Status

Variable type Variables generally collected
Self rated health compared to others of the same age Y

Mental Health Status

Variable type Variables generally collected
Psychiatric evaluations Y

Cognitive Status

Variable type Variables generally collected
Dementia Diagnosis Y
Alzheimer's Dementia Y
MCI Y
Subjective complaint Y

Lifestyle

Variable type Variables generally collected
Smoking Y
Pack Years Y
Current Smoking Y
Former Smoking Y
Alcohol Y
Units per day/week vs weekend Y
Specific beverage type (wine, spirits, beers) Y
Abstainers/ former users Y
Binge drinking Y
Type of exercise: heavy/light Y
Exercise duration Y
Occupation possible job matrices Y

Physical Environment

Variable type Variables generally collected
Living situation Y

Physical Examination

Variable type Variables generally collected
Cardiovascular examination Y
Respiratory examination Y
Gait assessment Y
Opthalmic examination Y
Measures of hearing and visual impairment (as at baseline) Y
Hearing test Y

Biosample Assays

Variable type Variables generally collected
Blood collected Y
Autopsy data Y
Saliva Y

Digital Phenotyping

Variable type Variables generally collected
Visual memory Y
Visuospatial function Y
Attention Y
Language Y
Working Memory Y
Latent Memory Y
Abstraction Y
CAMCOG Y
IQ data Y
NART Y
MMSE Y
Addenbrooke's Cognitive Exam (ACE) Y
Cambridge Examination for Mental Disorders in the Elderly Y
Neuropathological assessment following the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) standard protocol Y

Genomics

Variable type Variables generally collected
APOE gene screening (Subgroup) Y