Cohort Descriptives

Variable Response
Cohort Name Imperial Amyloid PET Cohort
Cohort Acronym Imperial APC
Study Overview The Imperial APC Study is an Alzheimer's Society funded project that was set up at the Imperial College London in 2019. The ovearching aim of the study is to investigate the diagnostic utility of amyloid PET and other more established biomarkers of AD in a clinical cohort of patients with atypical clinical presentations. In this sub-study, we have retrospectively collected the MRI scans of all individuals referred for amyloid PET imaging in our Centre between 2013 and 2021. Both MRI and amyloid PET scans were carried out for clinical purposes and referral to amyloid PET followed appropriate use criteria (Johnson et al., 2013 Alz & Dem).
#Subjects at Baseline 351
Institution Name Imperial College London
Department Name Brain Sciences
City London
Study/Database Website

see publications

Principal Investigator (PI) Dr Paresh Malhotra
Key Study References

Carswell, C. J., Win, Z., Muckle, K., Kennedy, A., Waldman, A., Dawe, G., ... & Perry, R. J. (2018). Clinical utility of amyloid PET imaging with (18) F-florbetapir: a retrospective study of 100 patients. Journal of Neurology, Neurosurgery & Psychiatry, 89(3), 294-299. Kolanko, M. A., Win, Z., Loreto, F., Patel, N., Carswell, C., Gontsarova, A., ... & Malhotra, P. A. (2020). Amyloid PET imaging in clinical practice. Practical neurology, 20(6), 451-462. Loreto, F., Gunning, S., Golemme, M., Watt, H., Patel, N., Win, Z., ... & Malhotra, P. A. (2021). Evaluating cognitive profiles of patients undergoing clinical amyloid-PET imaging. Brain Communications, 3(2), fcab035.

Population Based Study? No
Family Based Study? No
Clinical based sample? Yes
Is there follow-up data available? No
Were participants included prior to development of dementia (may refer to controls only)? Yes, this clinical cohort included patients with MCI and patients with dementia
Were participants included prior to development of MCI (may refer to controls only)? No
How is data collected? Data were collected retrospectively. Clinical scans were anonymised at source by members of the study team and then shared with the research team under the Imperial APC Study.
Who carries out data collection? Research Study coordinator in collaboration with the Imperial Clinical Team
Does this take place in participants' homes or at a central location? Patients included in this study were all seen at the Imperial College Healthcare NHS Trust Memory clinic. Most MRI scans were performed at Imperial, while a subset of scans were performed externally (by the referring site) and imported at Imperial
Do participants take part individually or are families/partners involved? Individual participation
Dementia cases ascertained as part of study: n/a
How many times followed up? 0
Study start date 08/06/2020 00:00:00
Study end date 01/01/2023 00:00:00
Is study ongoing? Yes
Is study still recruiting? Yes
Inclusion criteria Referral for clinical amyloid PET in line with appropriate use criteria (see Johnson et al., 2013) and available MRI scan within 12 months of amyloid PET
Exclusion criteria Unavailable MRI scan