Cohort Descriptives
| Variable | Response |
|---|---|
| Cohort Name | Generation Scotland: Scottish Family Health Study |
| Cohort Acronym | GS: SFHS |
| DOI | Porteous, D. (2017). GS: SFHS [Data set]. Dementias Platform UK. https://doi.org/10.48532/026000 |
| Study Overview | The aim of GS: SFHS is to establish a large, family-based intensively-phenotyped cohort recruited from the general population across Scotland, as a resource for studying the genetics of health areas of current and projected public health importance. It aims to identify genetic variants accounting for variation in levels of quantitative traits underlying the major common complex diseases (such as cardiovascular disease, cognitive decline, mental illness) in Scotland. DNA and non-identifiable information from this cohort will be made available to researchers in Scotland and international collaborators. Baseline data was collected at a single clinic visit. Longitudinal data is available by linkage to NHS medical records. Some participants are being invited to new clinic visits in 2015-17. This profile also includes scanning information from the Stratifying Resilience and Depression Longitudinally (STRADL) study to which approximately 3,000 GS participants have been invited for scanning. |
| #Subjects at Baseline | 21476 plus 2484 postal participants (saliva for DNA, pre-clinic questionnaire, PCQ). 59% female.. |
| Institution Name | Universities of Edinburgh, Aberdeen, Dundee and Glasgow and NHS Scotland |
| Department Name | Institute of Genetics & Molecular Medicine, University of Edinburgh |
| City | Edinburgh |
| Study/Database Website | |
| Principal Investigator (PI) | Prof David Porteous |
| Key Study References | |
| Population Based Study? | Yes |
| Family Based Study? | Yes |
| Clinical based sample? | No |
| Is there follow-up data available? | Yes |
| Were participants included prior to development of dementia (may refer to controls only)? | Yes |
| Were participants included prior to development of MCI (may refer to controls only)? | Yes |
| How is data collected? | Mostly in person but some people are contacted through post: 21,476 plus 2,484 postal participants |
| Who carries out data collection? | Interviewers and clinical staff: research nurses |
| Does this take place in participants' homes or at a central location? | Central |
| Do participants take part individually or are families/partners involved? | Individually and Family |
| Dementia cases ascertained as part of study: | No |
| Diagnosis based on review of existing clinical data | No |
| Was diagnosis/primary outcomes made blind to exposure variables? | No |
| How many times followed up? | Less often: Follow up is through NHS linkage data. However, some of the cohort have been invited into the Stratifying Resilience and Depression Longitudinally (STRADL) study that will involve MRI scans (approx 10% of the cohort). |
| Study start date | 23/01/2006 00:00:00 |
| Is study ongoing? | Yes |
| Is study still recruiting? | No |
| Inclusion criteria | Originally, the team only recruited people with family members who would also take part. Probands increased to include aged 18+. |
| Exclusion criteria | Unable to consent. |
Administration
| Variable type |
|---|
| Age At Participation |
| Appointment Date |
| Clinic Code |
| Family ID |
| Gender |
| Health Board Code (Data Collection) |
| ID Of Father/Mother |
| In GWAS #1 |
| In SFHS |
| Linkage Identifier |
| Month/Year Of Birth |
| Postcode Area |
Sociodemographic
| Sub-category | Variable type | Baseline |
|---|---|---|
| Deprivation | Accommodation status | Y |
| Deprivation | Number of cars/vans available to household | Y |
| Education | Highest educational qualification | Y |
| Education | Number of years at school/full time study | Y |
Family History
| Sub-category | Variable type | Baseline |
|---|---|---|
| Father | Alzheimer's/Parkinson's disease | Y |
| Father | Asthma/COPD | Y |
| Father | Cancer/type diagnosed with | Y |
| Father | Country/area father was born | Y |
| Father | Depression | Y |
| Father | Diabetes | Y |
| Father | Father's age at death/year of death | Y |
| Father | Father's year of birth | Y |
| Father | Heart disease/high blood pressure | Y |
| Father | Hip fracture | Y |
| Father | Osteoarthritis/rheumatoid arthritis | Y |
| Father | Stroke | Y |
| Gparents | Alzheimer's/Parkinson's disease | Y |
| Gparents | Asthma/COPD | Y |
| Gparents | Cancer/type diagnosed with | Y |
| Gparents | Depression | Y |
| Gparents | Diabetes | Y |
| Gparents | Grandparents' birth locations | Y |
| Gparents | Heart disease/high blood pressure | Y |
| Gparents | Hip fracture | Y |
| Gparents | Osteoarthritis/rheumatoid arthritis | Y |
| Gparents | Stroke | Y |
| Mother | Alzheimer's/Parkinson's disease | Y |
| Mother | Asthma/COPD | Y |
| Mother | Cancer/type diagnosed with | Y |
| Mother | Depression | Y |
| Mother | Diabetes | Y |
| Mother | Heart disease/high blood pressure | Y |
| Mother | Hip fracture | Y |
| Mother | Mother year of birth/death | Y |
| Mother | Osteoarthritis/rheumatoid arthritis | Y |
| Mother | Stroke | Y |
| Siblings | Alzheimer's/Parkinson's disease | Y |
| Siblings | Asthma/COPD | Y |
| Siblings | Cancer/type diagnosed with | Y |
| Siblings | Depression | Y |
| Siblings | Diabetes | Y |
| Siblings | Heart disease/high blood pressure | Y |
| Siblings | Hip fracture | Y |
| Siblings | Osteoarthritis/rheumatoid arthritis | Y |
| Siblings | Stroke | Y |
Early Life History
| Sub-category | Variable type | Baseline |
|---|---|---|
| Birthplace | Country/area of birth | Y |
Physical Health Status
| Sub-category | Variable type | Baseline |
|---|---|---|
| Cancer | Bowel cancer | Y |
| Cancer | Breast cancer | Y |
| Cancer | Lung cancer | Y |
| Cancer | Prostate cancer | Y |
| Cardiothoracic | Heart disease | Y |
| Cardiothoracic | High blood pressure | Y |
| Cardiothoracic | Myocardial infarction | Y |
| Cardiothoracic | Possible angina | Y |
| Cerebrovascular | Stroke | Y |
| General Health | Diabetes | Y |
| General Health | Hip fracture | Y |
| Pain | Back pain | Y |
| Pain | Chest pain | Y |
| Pain | Chronic pain grade | Y |
| Pain | Stomach/abdominal pain | Y |
| Respiratory | Asthma | Y |
| Respiratory | COPD | Y |
| Rheumatology | Osteoarthritis | Y |
| Rheumatology | Rheumatoid arthritis | Y |
Reproductive History
| Sub-category | Variable type | Baseline |
|---|---|---|
| Female | Menstrual Information | Y |
Psychological Status
| Sub-category | Variable type | Baseline |
|---|---|---|
| Personality | Eysenck Personality Questionnaire | Y |
Mental Health Status
| Sub-category | Variable type | Baseline |
|---|---|---|
| Disorders | Current major disorder | Y |
| Disorders | SPQ-B (Schizotypal Personality Disorder) | Y |
| Mood | Depression self report | Y |
| Mood | General Health Questionnaire (GHQ) | Y |
| Mood | Number of psychotic episodes | Y |
Cognition
| Sub-category | Variable type | Baseline |
|---|---|---|
| Cognitive Performance | Digit-Symbol Coding | Y |
| Cognitive Performance | Logical Memory | Y |
| Cognitive Performance | Mill Hill Vocabulary | Y |
| Cognitive Performance | Verbal Fluency | Y |
| Cognitive Status | Alzheimer's disease | Y |
| Cognitive Status | Parkinson's disease | Y |
Lifestyle
| Sub-category | Variable type | Baseline |
|---|---|---|
| Alcohol | Alcohol units per week | Y |
| Alcohol | Ever had an alcoholic drink | Y |
| Smoking | Age when started/stopped smoking | Y |
| Smoking | Smoking status | Y |
| Smoking | Years smoked | Y |
Physical Environment
| Sub-category | Variable type | Baseline |
|---|---|---|
| Housing | Total number of people in household | Y |
| Housing | Type of accommodation | Y |
| Housing | Whether live with partner | Y |
Physical Examination
| Sub-category | Variable type | Baseline |
|---|---|---|
| Anthropometry | Body Fat Composition (bio-impedance) | Y |
| Anthropometry | Body Mass Index | Y |
| Anthropometry | Height | Y |
| Anthropometry | Hips | Y |
| Anthropometry | Waist | Y |
| Anthropometry | Waist / Hip Ratio | Y |
| Anthropometry | Weight | Y |
| Heart | Blood pressure | Y |
| Heart | ECG | Y |
| Heart | Heart rate | Y |
| Lung | Lung function | Y |
Biosample Assays
| Sub-category | Variable type | Baseline |
|---|---|---|
| Biochemistry | Cholesterol | Y |
| Biochemistry | Creatinine | Y |
| Biochemistry | Glucose | Y |
| Biochemistry | Potassium | Y |
| Biochemistry | Sodium | Y |
| Biochemistry | Urea | Y |
| Biochemistry | Urine sample available | Y |
| Haematology | Plasma sample available | Y |
| Haematology | Serum sample available | Y |
| Haematology | Whole blood sample available | Y |
Imaging
| Sub-category | Variable type | Baseline |
|---|---|---|
| MRI | fMRI-rest | Y |
| MRI | T1-weighted MRI | Y |
| MRI | Diffusion | Y |
Genomics
| Sub-category | Variable type | Baseline |
|---|---|---|
| APOE | APOE | Y |
| Genotyping | DNA from saliva | Y |
| Genotyping | DNA sample | Y |
| Genotyping | Gene screening | Y |