Cohort Descriptives

Variable Response
Cohort Name Generation Scotland: Scottish Family Health Study
Cohort Acronym GS: SFHS
Study Overview The aim of GS: SFHS is to establish a large, family-based intensively-phenotyped cohort recruited from the general population across Scotland, as a resource for studying the genetics of health areas of current and projected public health importance. It aims to identify genetic variants accounting for variation in levels of quantitative traits underlying the major common complex diseases (such as cardiovascular disease, cognitive decline, mental illness) in Scotland. DNA and non-identifiable information from this cohort will be made available to researchers in Scotland and international collaborators. Baseline data was collected at a single clinic visit. Longitudinal data is available by linkage to NHS medical records. Some participants are being invited to new clinic visits in 2015-17. This profile also includes scanning information from the Stratifying Resilience and Depression Longitudinally (STRADL) study to which approximately 3,000 GS participants have been invited for scanning.
#Subjects at Baseline 21476 plus 2484 postal participants (saliva for DNA, pre-clinic questionnaire, PCQ). 59% female..
Institution Name Universities of Edinburgh, Aberdeen, Dundee and Glasgow and NHS Scotland
Department Name Institute of Genetics & Molecular Medicine, University of Edinburgh
City Edinburgh
Study/Database Website

http://www.generationscotland.org/

Principal Investigator (PI) Prof David Porteous
Key Study References

Please see Literature section

Population Based Study? Yes
Family Based Study? Yes
Clinical based sample? No
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? Mostly by person but some people are contacted through post: 21,476 plus 2,484 postal participants
Who carries out data collection? Interviewers and clinical staff: research nurses
Does this take place in participants' homes or at a central location? Central
Do participants take part individually or are families/partners involved? Individually and Family
Dementia cases ascertained as part of study: No
Diagnosis based on review of existing clinical data No
Was diagnosis/primary outcomes made blind to exposure variables? None
How many times followed up? Less often: Follow up is through NHS linkage data. However, some of the cohort have been invited into the Stratifying Resilience and Depression Longitudinally (STRADL) study that will involve MRI scans (approx 10% of the cohort).
Study start date 1/23/2006 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? No
Inclusion criteria Originally, the team only recruited people with family members who would also take part. Probands increased to include aged 18+.
Exclusion criteria Unable to consent.

Administration

Variable type Variables generally collected
Study ID Y
Age Y
Sex Y

Sociodemographic

Variable type Variables generally collected
Age Y
Age at last follow-up Y
Age at time of death Y
Sex Y
Ethnicity Y
Years of education Y
Level of education Y
Employment status (Occupation recorded) Y
Socioeconomic status measures - Postcode and Scottish index of multiple deprivation Y

Physical Health Status

Variable type Variables generally collected
Cardiovascular disease data (If self-report in medical history) Y
Myocardial infarction (If self-report in medical history) Y
Hypertension (If self-report in medical history), Y
Systolic/diastolic BP Y
Mean arterial pressure Y
Cancer Y
Diabetic Status Y
Stroke data Y

Health Care Utilisation

Variable type Variables generally collected
Medication use Y
Hospital utilisation Y

Psychological Status

Variable type Variables generally collected
Personality evaluation - Eysenck Personality Questionnaire Revised Short Form Y
Schizotypical personality questionnaire (SPQ-B) Y
Mood disorder questionnaire (MDQ) Y

Mental Health Status

Variable type Variables generally collected
Psychiatric evaluations Y
Anxiety measure Y

Cognitive Status

Variable type Variables generally collected
Dementia Diagnosis Y

Lifestyle

Variable type Variables generally collected
Smoking Y
Pack years Y
Passive smoking Y
Current smoking Y
Former smoking Y
Alcohol Y
Units per day/week vs weekend Y
Specified beverage type (wine, spirits, beers - For some participants) Y
Abstainers/former users Y
Physical activity and exercise Y
Type of exercise: heavy,light Y
Occupation possible job matrices Y
Diet: Carbs, protein, fats, fish oil Y
Food questionnaires Y

Physical Environment

Variable type Variables generally collected
Living situation Y

Physical Examination

Variable type Variables generally collected
Blood pressure (Assessed before onset of dementia) Y
Weight (Assessed before onset of dementia) Y
Height (Assessed before onset of dementia) Y
Heart Rate (Assessed before onset of dementia) Y
Anthropometry (Assessed before onset of dementia - Bioimpedence measure of body fat) Y
ECG (Assessed before onset of dementia) Y
Specific assessment of peripheral vascular disease (Assessed before onset of dementia) Y
Spirometry (Assessed before onset of dementia) Y
BMI Y
Hip/waist circumference Y
Fat percentage (Bioimpedence) Y
Metabolic syndrome Y

Biosample Assays

Variable type Variables generally collected
Serum Y
DNA Y
Urine Y
Saliva (Subgroup) Y

Digital Phenotyping

Variable type Variables generally collected
Verbal memory Y
Reaction time Y
Language Y
Working memory Y
Digit symbol test Y

Imaging

Variable type Variables generally collected
Structural T1 Y
Fluid attenuation inversion recovery (FLAIR): Y
Diffusion imaging (DTI/DWI) Y
f-MRI (task) Y
f-MRI (rest) Y

Genomics

Variable type Variables generally collected
GWAS (Caucasian genotyped only) Y
Whole genome sequenced (20 people) Y
APOE gene screening Y

Metabolomics

Variable type Variables generally collected
eGFR (estimated Glomular Filtration Rate) Y
Glucose Y
Serum creatinine Y