Cohort Descriptives

Variable Response
Cohort Name Generation Scotland: Scottish Family Health Study
Cohort Acronym GS: SFHS
Study Overview The aim of GS: SFHS is to establish a large, family-based intensively-phenotyped cohort recruited from the general population across Scotland, as a resource for studying the genetics of health areas of current and projected public health importance. It aims to identify genetic variants accounting for variation in levels of quantitative traits underlying the major common complex diseases (such as cardiovascular disease, cognitive decline, mental illness) in Scotland. DNA and non-identifiable information from this cohort will be made available to researchers in Scotland and international collaborators. Baseline data was collected at a single clinic visit. Longitudinal data is available by linkage to NHS medical records. Some participants are being invited to new clinic visits in 2015-17. This profile also includes scanning information from the Stratifying Resilience and Depression Longitudinally (STRADL) study to which approximately 3,000 GS participants have been invited for scanning.
#Subjects at Baseline 21476 plus 2484 postal participants (saliva for DNA, pre-clinic questionnaire, PCQ)
Institution Name Universities of Edinburgh, Aberdeen, Dundee and Glasgow and NHS Scotland
Department Name Institute of Genetics & Molecular Medicine, University of Edinburgh
City Edinburgh
Study/Database Website

http://www.generationscotland.org/

Principal Investigator (PI) Professor David Porteous
Key Study References

Please see Publications section

Population Based Study? Yes
Family Based Study? Yes
Clinical based sample? No
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? Mostly by person but some people are contacted through post: 21,476 plus 2,484 postal participants
Who carries out data collection? Interviewers and clinical staff: research nurses
Does this take place in participants' homes or at a central location? Central
Do participants take part individually or are families/partners involved? Individually and Family
Dementia cases ascertained as part of study: No
Diagnosis based on review of existing clinical data No
Was diagnosis/primary outcomes made blind to exposure variables? None
How many times followed up? Follow up is through NHS linkage data. However, some of the cohort have been invited into the Stratifying Resilience and Depression Longitudinally (STRADL) study has involved MRI scans (approx 10% of the cohort).
Study start date 1/23/2006 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? No
Inclusion criteria Originally, the team only recruited people with family members who would also take part. Probands increased to include aged 18+.
Exclusion criteria Unable to consent.

Administration

Variable type
VARIABLES PRESENT IN ALL FOLLOW-UPS
Age at participation
linkage identifier
Month of birth
Sex
Year of birth
Appointment date
Health Board code (data collection)
Clinic code
Family ID
Father ID
In GWAS #1
Mother ID
In SFHS
Postcode area

Sociodemographic

Sub-category Variable type Screening Follow-Up Long-Term Follow-Up
Deprivation Are you living with anyone in your household as a couple? Y    
Deprivation Including yourself, how many people live in your household? Y    
Deprivation What is the status of the accommodation? Y    
Deprivation How many cars/vans are available-you and your household? Y    
Deprivation What type of accommodation do you live in? Y    
Education What is the highest eductional qualification you have obtained? Y    
Education How many years altogether did you attend school or study full-time? Y    

Family History

Sub-category Variable type Screening Follow-Up Long-Term Follow-Up
Father Alzheimer's Disease Y    
Father Asthma Y    
Father Bowel Cancer Y    
Father Breast Cancer Y    
Father COPD Y    
Father Depression Y    
Father Diabetes Y    
Father Heart Disease Y    
Father High Blood Pressure Y    
Father Hip Fracture Y    
Father Lung Cancer Y    
Father Osteoarthritis Y    
Father Parkinson's Y    
Father Prostate Cancer Y    
Father Rheumatoid Arthritis Y    
Father Stroke Y    
Father area father was born Y    
Father Father age at death Y    
Father Father year of birth Y    
Father Father year of death Y    
Father country father was born Y    
Gparents Alzheimer's Disease Y    
Gparents Asthma Y    
Gparents Bowel Cancer Y    
Gparents Breast Cancer Y    
Gparents COPD Y    
Gparents Depression Y    
Gparents Diabetes Y    
Gparents Heart Disease Y    
Gparents High Blood Pressure Y    
Gparents Hip Fracture Y    
Gparents Lung Cancer Y    
Gparents Osteoarthritis Y    
Gparents Parkinson's Y    
Gparents Prostate Cancer Y    
Gparents Rheumatoid Arthritis Y    
Gparents Stroke Y    
Gparents Grandparents birth location's Y    
Mother Mother year of birth Y    
Mother Mother year of death Y    
Mother Alzheimer's Disease Y    
Mother Asthma Y    
Mother Bowel Cancer Y    
Mother Breast Cancer Y    
Mother COPD Y    
Mother Depression Y    
Mother Diabetes Y    
Mother Heart Disease Y    
Mother High Blood Pressure Y    
Mother Hip Fracture Y    
Mother Lung Cancer Y    
Mother Osteoarthritis Y    
Mother Parkinson's Y    
Mother Prostate Cancer Y    
Mother Rheumatoid Arthritis Y    
Mother Stroke Y    
Siblings Alzheimer's Disease Y    
Siblings Asthma Y    
Siblings Bowel Cancer Y    
Siblings Breast Cancer Y    
Siblings COPD Y    
Siblings Depression Y    
Siblings Diabetes Y    
Siblings Heart Disease Y    
Siblings High Blood Pressure Y    
Siblings Hip Fracture Y    
Siblings Lung Cancer Y    
Siblings Osteoarthritis Y    
Siblings Parkinson's Y    
Siblings Prostate Cancer Y    
Siblings Rheumatoid Arthritis Y    
Siblings Stroke Y    

Early Life History

Sub-category Variable type Screening Follow-Up Long-Term Follow-Up
Birthplace Area volunteer was born Y    
Birthplace Country volunteer was born Y    

Physical Health Status

Sub-category Variable type Screening Follow-Up Long-Term Follow-Up
Cancer Bowel Cancer Y    
Cancer Breast Cancer Y    
Cancer Prostate Cancer Y    
Cancer Lung Cancer Y    
Cardiothoracic Heart Disease Y    
Cardiothoracic High Blood Pressure Y    
General Health Diabetes Y    
General Health Hip Fracture Y    
Neurological Stroke Y    
Pain Back Pain Y    
Pain Chest Pain Y    
Pain Chronic Pain Grade Y    
Pain Myocardial infarction Y    
Pain Possible angina Y    
Pain Stomach ache or abdominal pain Y    
Respiratory Asthma Y    
Respiratory COPD Y    
Rheumatology Osteoarthritis Y    
Rheumatology Rheumatoid Arthritis Y    

Reproductive History

Sub-category Variable type Screening Follow-Up Long-Term Follow-Up
Female Menstrual Information Y    

Psychological Status

Sub-category Variable type Screening Follow-Up Long-Term Follow-Up
Personality Eysenck Personality Questionnaire Y    
Personality SPQ-B (Schizotypal Personality Disorder) Y    
Personality Cognitive-Perceptual Y    

Mental Health Status

Sub-category Variable type Screening Follow-Up Long-Term Follow-Up
Mood Current major disorder Y    
Mood Depression self report Y    
Mood General Health Questionnaire (GHQ) Y    
Mood Number of psychotic episodes Y    

Cognitive Status

Sub-category Variable type Screening Follow-Up Long-Term Follow-Up
AD Alzheimer's Disease self report Y    
PD Parkinson's Disease self report Y    

Lifestyle

Sub-category Variable type Screening Follow-Up Long-Term Follow-Up
Alcohol Have you ever had an alcoholic drink? Y    
Alcohol Alcohol units per week Y    
Smoking Smoking status Y    
Smoking Age when started smoking Y    
Smoking Age when stopped smoking Y    
Smoking Years smoked Y    

Physical Examination

Sub-category Variable type Screening Follow-Up Long-Term Follow-Up
Anthropometry Body Mass Index Y    
Anthropometry Body Fat Composition (bio-impedance) Y    
Anthropometry Height Y    
Anthropometry Hips Y    
Anthropometry Waist Y    
Anthropometry Weight Y    
Anthropometry Waist / Hip Ratio Y    
Heart Blood pressure Y    
Heart Heart rate Y    
Heart ECG Y    
Lung Lung function Y    

Biosample Assays

Sub-category Variable type Screening Follow-Up Long-Term Follow-Up
Biochemistry Urine sample available Y    
Haematology Creatinine Y    
Haematology Creatinine Y    
Haematology Glucose Y    
Haematology Potassium Y    
Haematology Sodium Y    
Haematology Cholesterol Y    
Haematology Urea Y    
Haematology Plasma sample available Y    
Haematology Whole blood sample available Y    
Haematology Serum sample available Y    

Digital Phenotyping

Sub-category Variable type Screening Follow-Up Long-Term Follow-Up
Cognitive Performance Digit-Symbol Coding Y    
Cognitive Performance Logical Memory Y    
Cognitive Performance Mill Hill Vocabulary Y    
Cognitive Performance Verbal Fluency Y    

Imaging

Variable type

Genomics

Sub-category Variable type Screening Follow-Up Long-Term Follow-Up
APOE APOE Y    
Genotyping DNA from saliva Y    
Genotyping DNA sample Y    
Genotyping Gene screening Y