Cohort Descriptives

Variable Response
Cohort Name DPUK Synthetic dataset
Cohort Acronym DPUK Synth
Study Overview An example dataset to demonstrate the type of data that is held in DPUK cohorts. These data are not real and should only be used for training purposes.
#Subjects at Baseline 100
Institution Name University of Oxford
Department Name Department of Psychiatry
City Oxford
Study/Database Website

https://www.dementiasplatform.uk/

Principal Investigator (PI) Sarah Bauermeister
Key Study References

n/a

Population Based Study? No
Family Based Study? No
Clinical based sample? No
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Synthetic data
Were participants included prior to development of MCI (may refer to controls only)? Synthetic data
How is data collected? Synthetic data
Who carries out data collection? Synthetic data
Does this take place in participants' homes or at a central location? Synthetic data
Do participants take part individually or are families/partners involved? Synthetic data
Dementia cases ascertained as part of study: Synthetic data
Diagnosis based on review of existing clinical data No
Was diagnosis/primary outcomes made blind to exposure variables? No
How many times followed up? 3
# Subjects at Follow-up 100
Study start date 6/5/2015 12:00:00 AM
Is study ongoing? No
Is study still recruiting? No
Inclusion criteria N/a
Exclusion criteria N/a

Administration

Variable type
ID Number
Patient's Date Of Birth
Gender Of Patient
Date Of Initial Visit
Consent To Approach For Update Of Patient
Date of baseline interview
Date of wave 1
Date of wave 2
Date of wave 3
Age at baseline interview
Age at wave 1
Age at wave 2
Age at wave 3

Sociodemographic

Sub-category Variable type Baseline 1 2 3
Deprivation State benefits Y      
Deprivation State pension Y      
Deprivation Earnings Y      
Deprivation Vehicle ownership Y      
Deprivation Subjective social status Y      
Deprivation Townsend deprivation index Y      
Deprivation Type of accommodation lived in Y      
Deprivation Number in household Y      
Employment Current employment status Y      
Employment Main job details Y      
Employment Normal working hours Y      
Employment Age of retirement (if retired) Y      
Employment Reason for retirement (if retired) Y      
Employment Health limiting ability to work Y      
Employment Average daily commute time (minutes) Y      
Employment Type of transport used for commute Y      
Ethnicity Ethnic group Y      
Ethnicity Country of birth Y      
Education Educational qualification level Y      
Education Age completed full-time education Y      
Insurance Life Assurance Y      
Insurance Possession Insurance Y      
Marital Status Marital status Y      

Family History

Sub-category Variable type Baseline 1 2 3
Adopted Were you adopted? Y      
Siblings Number of brothers Y      
Siblings Number of sisters Y      
Siblings AD history - Brother Y      
Siblings AD history - Sister Y      
Siblings PD history - Brother Y      
Siblings PD history - Sister Y      
Siblings Stroke history - Brother Y      
Siblings Stroke history - Sister Y      
Father Father still alive Y      
Father AD history - Father Y      
Father PD history - Father Y      
Father Stroke history - Father Y      
Mother Mother still alive Y      
Mother AD history - Mother Y      
Mother PD history - Mother Y      
Mother Stroke history - Mother Y      
Grandparents AD history - Grandparent Y      
Grandparents PD history - Grandparent Y      
Grandparents Stroke history - Grandparent Y      

Early Life History

Sub-category Variable type Baseline 1 2 3
Birth Fertility Y      
Breastfed Were you breast fed? Y      
Mother Smoked Did your mother smoke? Y      
Childhood Environment Number of Children (natural and adopted) Y      
Childhood Environment Cohabiting and important non-cohabiting relationships Y      
Childhood Environment Housing and geographical mobility Y      
Childhood Environment Living situation when they were 10 years old Y      
Childhood Environment Jobs and earnings Y      
Childhood Environment Health including injuries, childhood health, smoking and gynaecology Y      
Childhood Environment Relationship with parents when they were a child Y      
Childhood Environment Other important and difficult events in their lives Y      
Childhood Environment Occupation of father Y      
Childhood Environment Parents divorced or separated Y      

Physical Health Status

Sub-category Variable type Baseline 1 2 3
Respiratory Physician diagnosed conditions: chronic lung disease Y      
Respiratory Physician diagnosed conditions: asthma Y      
Cardiothoracic Physician diagnosed conditions: Ischaemic heart disease Y      
Cardiothoracic Physician diagnosed conditions: stroke Y      
Cardiothoracic Physician diagnosed conditions: raised cholesterol Y      
ENT Hearing - self-reported health difficulties Y      
ENT Dental health - self reported health difficulties Y      
Cancer Physician diagnosed conditions: cancer Y      
Rheumatology Physician diagnosed conditions: arthritis Y      
Rheumatology Physician diagnosed conditions: osteoporosis Y      
Pain Back pain for 3+ months Y      
Pain Hip pain for 3+ months Y      
Pain Knee pain for 3+ months Y      
Pain Headaches for 3+ months Y      
Eyes Which eye(s) affected by glaucoma Y      
Eyes Which eye(s) affected by diabetic eye disease Y      
Eyes Which eye(s) affected by cataract Y      
Eyes Which eye(s) affected by macular degeneration Y      
General Health Self-rated general health Y      
General Health Physician diagnosed conditions: High Blood pressure Y      
General Health Falls and resulting fractures if age 60+y Y      
General Health Balance problems or dizziness Y      
General Health Urinary incontinence Y      
General Health Mobility: difficulties walking 1/4 mile Y      
General Health Physician diagnosed conditions: diabetes Y      

Reproductive History

Sub-category Variable type Baseline 1 2 3
Men Age voice broke Y      
Men Age started shaving (beard growth) Y      
Women Number of children given birth to Y      
Women Age at menopause Y      

Healthcare Utilisation

Sub-category Variable type Baseline 1 2 3
Hospitalisation Quality of care (falls & fractures) Y      
Community Care Moved into nursing home Y      
Community Care Future housing and care needs Y      
Community Care Had short stays in residential/nursing homes Y      
Community Care Age 65+y: whether use meals on wheels Y      
Community Care Age 65+y: whether use day centres Y      
Community Care Age 65+y: whether use lunch clubs Y      
Community Care Quality of care, psychiatric and emotional problems Y      
Community Care Accessing local amenities and services Y      
Community Care Cancer screening participation Y      
Medications Number of treatments/medications taken Y      
Medications Medication for cholesterol Y      
Medications Medication for dementia Y      
Medications Medication for blood pressure Y      
Medications Medication for depression Y      
Medications Medication for diabetes Y      
Surgery Had major operations Y      
Surgery Hip and knee replacements received Y      
Surgery Hip and knee replacements quality of care Y      

Life Functionality

Sub-category Variable type Baseline 1 2 3
Daily Living ADLS listed Y      
Daily Living IADL listed Y      
Assistive Devices Mobility aids Y      
Assistive Devices Sources of help Y      

Psychological Status

Sub-category Variable type Baseline 1 2 3
Wellbeing Altruism Y   Y  
Wellbeing Satisfaction With Life Scale-SWLS (Diener) Y   Y  
Wellbeing Ryff well-being scale Y   Y  
Wellbeing ONS harmonised 4 questions on wellbeing Y   Y  
Sleep Sleep disturbance Y   Y  
Quality Of Life Social support Y   Y  
Quality Of Life Experience and perceptions of ageing Y   Y  
Quality Of Life Sense of collectiveness Y   Y  
Quality Of Life CASP-19 score Y   Y  
Quality Of Life Happiness Y   Y  
Quality Of Life Social isolation/loneliness Y   Y  
Quality Of Life Satisfaction with friendships Y   Y  
Quality Of Life Experiences of being mentored Y   Y  
Quality Of Life Generativity (passing skills/experience to younger generations) Y   Y  

Mental Health Status

Sub-category Variable type Baseline 1 2 3
Mood CES-D depression scale Y   Y  
Consultation Seen GP for nerves, anxiety, tension or depression? Y   Y  
Consultation Have you ever talked to a heath professional about unsual or psychotic experiences? Y   Y  
Disorders Do you have any Eating disorders? Y   Y  
Addictions Ever addicted to any substance or behaviour? Y   Y  
Addictions Ever addicted to alcohol? Y   Y  
Self Harm Have you ever self harmed? Y   Y  
Self Harm Ever attempted suicide? Y   Y  
Abuse Physically abused by family as a child? Y   Y  
Trauma Have you been the victim of physically violent crime? Y   Y  
Mood General Health Questionnaire (GHQ-12) Y   Y  
Mood Geriatric Depression Score (GDS-30) Y   Y  

Cognitive Status

Sub-category Variable type Baseline 1 2 3
PD Physician diagnosed conditions: Parkinson's disease Y      
AD Physician diagnosed conditions: Alzheimers Y      
Dementia Physician diagnosed conditions: dementia Y      
MCI Physician diagnosed: mild cognitive impairment Y      

Lifestyle

Sub-category Variable type Baseline 1 2 3
Smoking Smoking history Y      
Alcohol Alcohol consumption: usual frequency per week Y      
Alcohol Former alcohol drinker Y      
Substances Have you ever taken cannabis? Y      
Diet Consumption of fruit and vegetables per day Y      
Physical Number of days/week of vigorous physical activity 10+ minutes Y      
Physical Number of days/week of moderate physical activity 10+ minutes Y      
Physical Physical activity: whether job is sedentary or physically active Y      
Leisure Hours spent watching television daily Y      
Leisure Hours spent using computer daily Y      
Leisure Time spent driving Y      
Sexual Lifetime number of sexual partners Y      
Sexual Age first had sexual intercourse Y      
Leisure Volunteering Y      
Leisure Provision of unpaid help Y      
Leisure Pet ownership Y      

Physical Environment

Sub-category Variable type Baseline 1 2 3
Work Number of jobs held Y      
Work Job involves shift work Y      
Housing Number of people in household Y      
Housing Satisfaction with housing and area Y      
Housing Neighbourhood perceptions Y      
Sun Exposure Childhood sunburn occasions Y      
Sun Exposure Ease of skin tanning Y      

Social Environment

Sub-category Variable type Baseline 1 2 3
Life Events Civic, social and cultural participation Y      
Socialmedia Social network usage Y      
Socialmedia Digital inclusion Y      
Multimedia TV watching Y      
Multimedia Weekly usage of mobile phone in last 3 months Y      
Multimedia Plays computer games Y      
Life Events Perceived discrimination Y      
Social Interaction Proximity to children Y      
Social Interaction Time spent caring for grandchildren Y      

Physical Examination

Sub-category Variable type Baseline 1 2 3
Heart Diagnositc symptom assessments: Rose Angina Y Y Y Y
Heart Systolic blood pressure Y Y Y Y
Heart Diastolic blood pressure Y Y Y Y
Lung Lung function Y Y Y Y
Lung Diagnositc symptom assessments: MRC Respiratory Questionnaire Y Y Y Y
Sensory Sense of taste and smell Y Y Y Y
Eye RNFL Y Y Y Y
Eye TOPO Y Y Y Y
Eye UWFI Y Y Y Y
Anthropometry Height Y Y Y Y
Anthropometry Weight Y Y Y Y
Anthropometry Body Mass Index (BMI) Y Y Y Y
Anthropometry Body fat percentage Y Y Y Y
Anthropometry Digit Span Grade Y Y Y Y
Anthropometry Leg length Right Y Y Y Y
Anthropometry Leg length Left Y Y Y Y
Strength Grip strength (left hand) Y Y Y Y
Strength Grip strength (right hand) Y Y Y Y
Movement Edinburgh Claudication Questionnaire Y Y Y Y
Movement Chair stands Y Y Y Y
Movement Walking speed performance test (≥60 years) Y Y Y Y
Movement Falls in past year Y Y Y Y
Movement Single Trial Time Y Y Y Y
Movement Dual Trial Time Y Y Y Y
Movement Dual Trial Correct/Incorrect Y Y Y Y

Linkage Data

Sub-category Variable type Baseline 1 2 3
HES Spells in Hospital Y      
Death Register Year of death Y      
Death Register Age at death Y      
Death Register Cause of death Y      
Cancer Register Age at Cancer Diagnosis Y      

Biosample Assays

Sub-category Variable type Baseline 1 2 3
Haematology Haemoglobin concentration Y      
Haematology White blood cell count Y      
Haematology Red blood cell count Y      
Haematology Platelet count Y      
Haematology Triglycerides Y      
Haematology C-reactive protein Y      
Haematology Fibrinogen Y      
Haematology Ferritin Y      
Haematology Glycated haemoglobin Y      
Biochemistry Glucose level Y      
Biochemistry Total Cholesterol Y      
Biochemistry HDL Cholosterol Y      
Biochemistry Interleukins IL-1 Y      
Biochemistry Interleukins IL-6 Y      
Biochemistry Interleukins IL-8 Y      
Biochemistry Interleukins IL-10 Y      
Biochemistry Interleukins IL-12 Y      
Biochemistry Cortisol (from saliva) Y      
Biochemistry IGF-1 Y      
Biochemistry DHEAS Y      
Biochemistry Vitamin D Y      
Biochemistry CSF taken Y      

Digital Phenotyping

Sub-category Variable type Baseline 1 2 3
Cognitive Performance NART Y Y Y Y
Cognitive Performance MMSE Y Y Y Y
Cognitive Performance Rosen Y Y Y Y
Cognitive Performance CDR Y Y Y Y
Cognitive Performance ADAS-Cog Y Y Y Y
Cognitive Performance BADLS Y Y Y Y
Cognitive Performance CLOX 1 Y Y Y Y
Cognitive Performance CLOX 2 Y Y Y Y
Cognitive Performance Self-rated memory Y   Y  
Cognitive Performance Orientation in time Y   Y  
Cognitive Performance Word-list learning Y   Y  
Cognitive Performance Prospective memory Y   Y  
Cognitive Performance Logical memory Immediate Total Correct Y   Y  
Cognitive Performance Logical memory Delay Total Correct Y   Y  
Cognitive Performance Number series Y   Y  
Cognitive Performance Word-finding (verbal fluency) Y   Y  
Cognitive Performance Letter cancellation (accuracy and speed of mental processing) Y   Y  
Cognitive Performance Backwards counting Y   Y  
Cognitive Performance Serial 7s Y   Y  
Cognitive Performance Object naming Y   Y  
Cognitive Performance Numerical ability Y   Y  
Cognitive Performance Literacy ability Y   Y  
Cognitive Performance Proxy interview of cognitive funcitoning - IQCODE scale Y   Y  
Cognitive Performance RTI five-choice reaction time Y   Y Y
Cognitive Performance PAL Y   Y Y
Cognitive Performance Delayed PAL Y   Y Y
Cognitive Performance SWM Y   Y Y
Cognitive Performance RVP Y   Y Y
Cognitive Performance Simple Reaction Time Trials     Y  
Cognitive Performance Stroop Word Test, Congruent     Y  
Cognitive Performance Stroop Word Test, Incongruent     Y  
Cognitive Performance Strrop Arrow Test, Congruent     Y  
Cognitive Performance Strrop Arrow Test, Incongruent     Y  

Imaging

Sub-category Variable type Baseline 1 2 3
MRI Whole brain volume Y      
MRI White matter volume Y      
MRI Grey matter volume Y      

Genomics

Sub-category Variable type Baseline 1 2 3
APOE apoe4 Y      
APOE rs429358 Y      
APOE rs7412 Y      

Metabolomics

Sub-category Variable type Baseline 1 2 3
Blood based Alanine Aminotransferase Y      
Blood based Aspartate Aminotransferase Y      
Blood based Total Bilirubin Y      
Blood based Alkaline Phosphatase Y      
Blood based Albumin Y      
Blood based Total Protein Y      
Blood based Serum Folate Y      

Built Environment

Sub-category Variable type Baseline 1 2 3
Morphometrics Home distance from motorway Y      
Morphometrics Home distance from pylon Y      
Morphometrics Home distance from airport Y      
Morphometrics Home distance from railway line Y      
Morphometrics Home distance from coast Y      
Morphometrics Home distance from manufacturing plant Y      
Morphometrics Amount of green space within 1 mile of home Y      
Morphometrics Distance to major river or lake Y