| Cohort Name |
Cambridge Centre for Ageing and Neuroscience |
| Cohort Acronym |
Cam-CAN |
| DOI |
Henson, R. (2017). Cam-CAN [Data set]. Dementias Platform UK. https://doi.org/10.48532/009000 |
| Study Overview |
The aim of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) project is to identify the neural mechanisms underpinning successful cognitive ageing. The study used epidemiological, behavioural, and neuroimaging data to understand how individuals can best retain cognitive abilities into old age. A major aim of the research programme is to understand the nature of brain-cognition relationships across the lifespan, and to highlight the importance of abilities that are maintained into old age. The study was not designed to have repeated measures for each participant, but rather as one extended and comprehensive study visit that took places over 3 stages. |
| #Subjects at Baseline |
Approx 2700 had the Stage 1 interview, 700 at Stage 2, 280 at Stage 3. |
| Institution Name |
University of Cambridge |
| Department Name |
Department of Psychology |
| City |
Cambridge |
| Study/Database Website |
http://www.cam-can.com |
| Principal Investigator (PI) |
Professor Rik Henson |
| Key Study References |
Available in the Literature section |
| Population Based Study? |
Yes |
| Family Based Study? |
No |
| Clinical based sample? |
No |
| Is there follow-up data available? |
Yes |
| Were participants included prior to development of dementia (may refer to controls only)? |
Yes |
| Were participants included prior to development of MCI (may refer to controls only)? |
Yes |
| How is data collected? |
In person |
| Who carries out data collection? |
Interviewers |
| Does this take place in participants' homes or at a central location? |
Central |
| Do participants take part individually or are families/partners involved? |
Individually |
| Dementia cases ascertained as part of study: |
No |
| How many times followed up? |
2 |
| Study start date |
01/10/2010 00:00:00 |
| Study end date |
31/03/2016 00:00:00 |
| Is study ongoing? |
No |
| Is study still recruiting? |
No |
| Inclusion criteria |
For Stage 1: Aged 18+ Capacity to consent. Resident within Cambridge City. Not been excluded by GP.Points at the interview where it could be truncated based on tailoring the sample to the inclusion criteria for Stage 2 and 3. |
| Exclusion criteria |
For continuation to Stages 2 and 3 : MMSE score 24 or less (calculated in interview). Missing MMSE scores (assumed to be 24 or less). Severe memory defect. Consent difficulties for next stage. Communication difficulties: Hearing problems (difficulty completing interview with hearing aid, inability to hear 35 db at 1000 Hz in either ear in interview functional hearing screening, hearing aid that cannot be removed). Insufficient English language. Vision difficulties (correct near vision of 20/100 or worse with both eyes). Medical problems (self-report of diagnosis): Dementia diagnosis/Alzheimer's Disease. Parkinson's disease. Motor Neurone disease. Multiple Sclerosis. Cancer (history of brain tumour or chemotherapy/radiotherapy for any cancer in last 6 months). Stroke. Encephalitis. Meningitis. Epilepsy. Head injury with serious results (coma, unconscious for >2 hrs, or skull fracture). Recently diagnosed or uncontrolled high blood pressure. Pregnancy or trying to become pregnant. Current serious psychiatric conditions (bipolar disorder, schizophrenia, or psychosis). Mobility problems Restricted mobility which would prevent further participation. Inability to walk 10 metres. Substance abuse: Past or current treatment for drug abuse. Current drug usage. Refusal to answer substance abuse questions. Specific MRI/MEG safety and comfort exclusions: Heart operation. Blood vessel procedure or device (carotid artery vascular clamp, venous umbrella, stent, filter or coil, Swan-Ganz catheter, vascular access ports or catheters). Neurostimulator or spinal fusion stimulator. Electrodes on body, head or brain. Pump, Implant or pacemaker. Brain Operation. Metal splinters in eye, head or ear. Shrapnel, buckshot or bullet in body. Wire sutures or surgical staples. Artificial joints that are MRI incompatible (jaw/maxillary reconstruction, shoulder prosthesis, any other joint replacement surgery in the last 3 months). Bone fixation rods or plates in jaw, head, shoulders or spine. Non-removable dental brace.
Non-removable prosthesis or removable eye prosthesis. Inability to lie flat for an hour. Claustrophobia. Body piercings that cannot be removed. IUD that is MRI incompatible. Transdermal delivery patches that cannot be removed. Tattoos on head face or neck. |