Cohort Descriptives

Variable Response
Cohort Name Cognitive Function in Ageing Study II
Cohort Acronym CFAS II
Study Overview CFAS II started in 2008, and builds on the design and infrastructure of CFAS I. It will provide data on generational and geographical differences including people in institutions. It will also provide important base-line information on older people aged 65-84 in 2007-2008 who will reach the age of greatest frailty during the 2020s when the peak in the number of people aged 85 or over is expected and at a time when major therapeutic interventions for dementia could be expected to have an effect. Participants were followed up by interview. Objectives of core CFAS II include: • To provide profiles of cognitive and physical function, physical and mental health and disability of people aged 65 or over in three of the original CFAS centres. • To investigate whether the measures that characterise the intermediate stage (Mild Cognitive Impairment) best within original CFAS are stable across generations. • To quantify medication and health and social service use, social support, residential characteristics and care states, including formal and informal care, of people with dementia, frailty or physical disability across the three sites, to measure population differences over 16 years and to assess differences between urban and rural settings, and the new relationships between health, social factors and service receipt. • To compare healthy active life expectancy over time for the whole group and within social groups and assess whether over the last 16 years educational and occupational social groups have experienced differential change and whether there has been a trade off between physical and mental health expectancy. • To assess the contribution of different diseases, particularly dementia to any change in the burden of disability over time, specifically whether diseases have become more or less disabling and estimate the effect of prevention vs. treatment. • To compare the size of relationship of known genetic factors with frailty including cognitive impairment under different scenarios about future trends in cognitive impairment and disability. • To provide a foundation for other collaborative studies that investigates biomarkers and further investigation of early markers, including imaging, for risk of cognitive decline.
#Subjects at Baseline 7524
Institution Name University of Cambridge
Department Name Institute of Public Health
City Cambridge
Study/Database Website

http://www.cfas.ac.uk

Principal Investigator (PI) Prof Carol Brayne
Key Study References

Please see Publications

Population Based Study? Yes
Family Based Study? No
Clinical based sample? No
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? In person
Who carries out data collection? Interviewers
Does this take place in participants' homes or at a central location? Home
Do participants take part individually or are families/partners involved? Individually and Family: An informant interview for those with a cognitively impaired profile, and for a random selection of those without, was requested for 20% of the sample.
Dementia cases ascertained as part of study: Yes
Diagnosis based on review of existing clinical data No
Was diagnosis/primary outcomes made blind to exposure variables? No
How many times followed up? 2
How regular is follow-up? Every 2-3 years: 2 year follow up: Wave 1 (Baseline) and Wave 2 (2 years later). Wave 3 planned for late 2015.
Study start date 1/1/2008 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? No
Inclusion criteria Born before 1942. Speaks English proficiently. Lives in the cohort catchment area.
Exclusion criteria Born after 1942. Anyone not proficient in English will be excluded from the sample.

Administration

Variable type Variables generally collected
Study ID Y
Age Y
Sex Y

Sociodemographic

Variable type Variables generally collected
Age Y
Age at time of dementia diagnosis Y
Age at last follow-up Y
Age at time of death Y
Sex Y
Ethnicity Y
Years of education Y
Level of education Y
Townsend deprivation scores Y

Physical Health Status

Variable type Variables generally collected
Cardiovascular disease Y
Myocardial infarction (Age of onset, relative to dementia, known) Y
Medication use for CVD (Age of onset, relative to dementia, known) Y
Hypertension (Age of onset, relative to dementia, known) Y
Cancer Y
Diabetic Status Y
Stroke data Y
Transient Ischemic Attack Y
Head trauma data Y
Loss of consciousness Y

Health Care Utilisation

Variable type Variables generally collected
Hospital utilisation Y
Medication Use Y
Medication Use for CVD (Age of onset, relative to dementia, known) Y
Informants interviewed about care giving Y
Admission to Nursing home Y
Admission to home care Y
Day care at nursing home Y
Day care at home for elderly Y
Home care-domestic Y
Home care-personal care Y
Home care-nursing Y
Physical therapist Y
Care of community mental health team Y
Permanent stay at nursing home Y
Informal ADL care Y
Informal iADL care Y

Psychological Status

Variable type Variables generally collected
Comprehensive assessments of quality of life and health from self reported interview Y
Personality evaluation (Informant interview) Y
Apathy evaluation Y
Anxiety measure Y

Mental Health Status

Variable type Variables generally collected
Psychiatric Evaluations Y

Cognitive Status

Variable type Variables generally collected
Dementia Diagnosis Y
Alzheimer's Dementia Y
MCI Y
Subjective complaint Y

Lifestyle

Variable type Variables generally collected
Smoking Y
Pack Years Y
Current smoking Y
Former smoking Y
Alcohol Y
Units per day/week vs weekend Y
Specified beverage type (wine, spirits, beers) Y
Abstainers/former users Y
Binge drinking Y
Drugs of abuse assessment Y
Type of exercise: heavy, light Y
Exercise duration Y
Diet Y

Physical Environment

Variable type Variables generally collected
Living situation Y

Physical Examination

Variable type Variables generally collected
Gait assessment Y
Measures of hearing and visual impairment (as at baseline) Y
Hearing test Y

Biosample Assays

Variable type Variables generally collected
Saliva Y

Digital Phenotyping

Variable type Variables generally collected
MMSE Y
Cambridge Examination for Mental Disorders in the Elderly, including CAMCOG Y
Automated Geriatric Examination for Computer Assisted Taxonomy (AGECAT) Y

Genomics

Variable type Variables generally collected
APOE Gene Screening Y