Cohort Descriptives

Variable Response
Cohort name The Cognitive Health in Ageing Register: Investigational, Observational, and Trial studies in dementia research
Cohort acronym CHARIOT
General Study Overview Identifying cognitively healthy people at high risk of developing dementia is an ever-increasing focus. The success of research in this area is dependent on having access to a well characterised, representative and sufficiently large population of individuals. The CHARIOT register is a primary care-based recruitment register for research into the prevention of dementia. The CHARIOT register was designed specifically to support recruitment into observational natural history studies of pre-symptomatic or prodromal dementia stages, and primary or secondary prevention pharmaceutical trials or other prevention strategies for dementia and other cognitive problems associated with ageing.
Number of subjects at baseline 28,000
Institution name Imperial College London
Department name Neuroepidemiology and Ageing Research Unit
City London
Principal Investigator (PI): Name Prof Lefkos Middleton
PI: Address Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, United Kingdom
PI: email

l.middleton@imperial.ac.uk

PI: phone +44 (0)20 3311 0216
Administrative Contact (AC): Name Lisa K Curry
AC: Address Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, United Kingdom
AC: email L.curry@imperial.ac.uk
AC: phone +44 (0)20 3311 0323
Key study references

Open literature list

Population based study? Yes
Family based study? No
Clinical based sample? No
Is there follow-up data available? No
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
Dementia cases ascertained as part of study: No
Diagnosis based on review of existing clinical data No
Is study ongoing? Yes
Is study still recruiting? Yes
Inclusion criteria Aged 50-85 inclusive
Exclusion criteria Diagnosis of dementia of any type
Psychotic conditions

Demographic and Clinical Information

Variable Response
Demographics
Age Yes
Age at time of diagnosis of dementia No
Age at time of death No
Sex Yes
Ethnicity Yes
Education No
Physical examinations
Any physical examination performed? No
Medical conditions
Cardiovascular disease data No
Hypercholesterolemia No
Virus testing No data available
Olfactory sensitivity No
Medication use No

Cognitive Outcomes

Variable Response
Any domain-specific cognitive test performed? No
IQ data available? No
Cognitive background? No
Standard dementia global cognition scales? No

Non-Cognitive Clinical Outcomes

Variable Response
Dementia diagnosis
Alzheimer's dementia No
Lewy Body Disease No
Huntingtons Disease No
Parkinsons Disease No
Frontotemporal dementia No
Vascular dementia No
MCI No
Subjective complaint No
Functional rating scales
Any information on dementia rating collected? No
Any information on subjective complaints collected? No
Any neuropsychiatric rating scale administered? No
Any Quality of Life Data Colllected? No
Any information on Caregivers and Caregiving Collected? No
Health service utilisation
Any Health Resource Utilisation Collected ? No
Other neurological or psychiatric measurements? No

Imaging

Variable Response
Structural T1 Not acquired
Not acquired
Fluid attenuation inversion recovery (FLAIR) Not acquired
Not acquired
Diffusion imaging (DTI/DWI) Not acquired
Not acquired
f-MRI (task) Not acquired
Not acquired
f-MRI (rest) Not acquired
Not acquired
PET Not acquired
Not acquired
SPECT Not acquired
Not acquired
MEG Not acquired
Not acquired
In vivo Spectroscopy Not acquired
Not acquired

Genetics

Variable Response
Overview
Gene screening

Biological samples

Variable Response
Blood collected No
Blood Metabolic Analytes
Urine collection
Urine No
Autopsy data
Autopsy No
Saliva
Saliva collected No
CSF
CSF collected No
mtDNA abnormalities No
Oxidative stress No
synuclein No

Brain donation

Variable Response
Is brain donation part of the existing protocol? No
Are information sheets made available to representative or consultees? No
Are retrospective interviews carried out after the participant's death? No
Is there a procedure for declining donation/failed recruitment/project termination? No
Has an actuarial analysis been completed? No

Lifestyle

Variable Response
Smoking No
Drugs of abuse assessment
Obesity and associated risk factors
Physical activity and exercise No
Diet No
Employment status
Living situation
Socioeconomic status
Socioeconomic status measures Data available: Index of Multiple Deprivation–IMD
Sleep assessment

Ethics and Engagement

Variable Response
Participant engagement
Ethics
Does the cohort include participants who lack capacity? No
Is there a process in place for participants who lose capacity? No
Do participants provide contact information for a person to act as a potential consultee? No
Disclosure
Do procedures exist for the disclosure of incidental findings? No
Do procedures exist for the disclosure of clinically relevant information identified as a direct focus of the study? (e.g. a diagnosis of dementia) No
Recruitment
How was the cohort recruited (NHS or not, primary or secondary care)? Participants were recruited through searches of general practice lists across the west and central London regions. Invitations were posted to individuals aged between 60 and 85 years, without a diagnosis of dementia.
Does the study involve ongoing connections with participants' own doctors (e.g. GPs)? Yes
Consent and recontact
Is there consent for recontact? Yes

Data Management

Variable Response
Consent for linkage to routine data
Which parts of the UK are represented by participants in your cohort? England
England