Cohort Descriptives

Variable Response
Cohort Name Whitehall II
Cohort Acronym Whitehall II
Study Overview The Whitehall II Study was established in 1985 to investigate the importance of socioeconomic circumstances for health by following a cohort of working men and women aged 35-55 at enrolment. Participants have taken part in eleven data collection phases, six of which have included a medical screening. The 12th is currently underway. The aim of the study is to understand the causes of age-related heterogeneity in health. By combining the existing 28 years of data on social inequalities and chronic disease with new clinical measures of cognitive function, mental disorders and physical functioning, Whitehall II has been transformed interdisciplinary study of ageing. In addition to providing insights into individual and social differences in the development of frailty, disability, dependence, and dementia, the study will enable the determination of optimal time windows and targets for interventions that maximise the potential for healthy-ageing and independent living.
#Subjects at Baseline 10,308: 3413 women and 6895 men
Institution Name University College London
Department Name Department of Epidemiology & Public Health
City London
Study/Database Website

https://www.ucl.ac.uk/whitehallII

Principal Investigator (PI) Professor Mika Kivimaki
Key Study References

Please see Literature section

Population Based Study? Yes
Family Based Study? No
Clinical based sample? No
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? In person
Who carries out data collection? Interviewers and Clinical staff: Mix of nurses and technicians and trained interviewers. Data reviewed by clinicians.
Does this take place in participants' homes or at a central location? Central
Do participants take part individually or are families/partners involved? Individually
Dementia cases ascertained as part of study: No
Diagnosis based on review of existing clinical data No
Was diagnosis/primary outcomes made blind to exposure variables? No
How many times followed up? 11
Study start date 1/30/1985 12:00:00 AM
Study end date 12/30/2030 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? No
Inclusion criteria Civil servant working in the London offices of 20 Whitehall departments in 1985–88 Aged 35-55 Capacity to consent

Administration

Variable type Variables generally collected
Study ID Y
Age Y
Sex Y

Sociodemographic

Variable type Variables generally collected
Age Y
Age at last follow-up Y
Age at time of death Y
Sex Y
Ethnicity Y
Years of education Y
Level of education Y
Employment status Y
Socioeconomic status measures Y

Family History

Variable type Variables generally collected
Parental education Y

Physical Health Status

Variable type Variables generally collected
Cardiovascular disease data Y
Echography Y
Myocardial infarction Y
Medication use for CVD Y
Hypertension Y
Systolic/Diastolic BP Y
Mean arterial pressure Y
Hypotension Y
Hypercholesterolemia Y
Cancer Y
Diabetic Status Y
Stroke data Y
Stroke type Y
Transient Ischemic Attack Y
Head trauma data Y

Healthcare Utilisation

Variable type Variables generally collected
Medication use Y
Medication use for CVD Y
Hospital Utilisation Y

Life Functionality

Variable type Variables generally collected
Katz ADL Y
Lawton IADL Y

Psychological Status

Variable type Variables generally collected
Short Form (SF) 36 Y
General Health Questionnaire (GHQ) Y
Days of work absence if having a paid job Y
Resilience measure Y
Jenkins Sleep Questionnaire (JSQ) Y
Pittsburgh Sleep Quality Index (PSQI) Y
Diurnal saliva cortisol levels (circadian) Y

Mental Health Status

Variable type Variables generally collected
Center for Epidemiologic Studies Depression scale (CES-D) Y
Hamilton depression rating scale (HDRS) Y
Apathy evaluation Y
Anxiety measure Y

Cognitive Status

Variable type Variables generally collected
Dementia diagnosis Y

Lifestyle

Variable type Variables generally collected
Smoking Y
Pack years Y
Passive smoking Y
Current smoking Y
Former smoking Y
Alcohol Y
Units per day/weekend Y
Specified beverage type (wine, spirits, beers) Y
Abstainers/former users Y
Alcohol Use Disorders Identification Test (AUDIT) Y
CAGE questionnaires part of the Whitehall II Imaging substudy Y
Family History of Alcoholism Y
Physical activity and exercise Y
Type of exercise: heavy, light Y
Exercise duration Y
CHAMPS Physical Activity Questionnaire for Older Adults Y
Locus for Causality Exercise Questionnaire (LCE) Y
Diet: Carbs, protein, fats, fish oil Y
Vegetarian? Y
Coffee and Caffeine Y
Vitamin A, B, E Y
Fat intake MUFA, PUFA Y
(Food Frequency Questionnaire) Y
Body Image Questionnaire Y
Three-Factor Eating questionnaire Y

Physical Environment

Variable type Variables generally collected
Living situation Y

Physical Examination

Variable type Variables generally collected
Blood pressure (assessed before onset of dementia) Y
Weight (assessed before onset of dementia) Y
Height (assessed before onset of dementia) Y
Heart Rate (assessed before onset of dementia) Y
Anthropometry (assessed before onset of dementia) Y
ECG (Minnesota coding) (assessed before onset of dementia) Y
Cardiovascular examination (assessed before onset of dementia) Y
Respiratory examination (assessed before onset of dementia) Y
Spirometry (assessed before onset of dementia) Y
Gait assessment (Walking speed) (assessed before onset of dementia) Y
Endothelial dysfunction (subgroup) Y
Carotid artery wall thickness/distensibility (subgroup) Y
Heart rate variability Y
HPA axis measurements (subgroup) Y
Salivary cortisol diurnal rhythm Y
Chair rises Y
Pulse Wave Velocity Y
Purdue Pegboard Task Y
BMI Y
Hip/waist circumference Y
Dyslipidemia Y
Blood lipids Y
Metabolic syndrome Y

Biosample Assays

Variable type Variables generally collected
Plasma Y
Serum Y
DNA Y
Urine (Repeated collection) Y
Saliva (Repeated collection) Y
Cortisol Y

Digital Phenotyping

Variable type Variables generally collected
Verbal memory Y
Visuospatial Function Y
Reaction time Y
Language Y
Working memory Y
IQ data Y
MMSE (Repeated collection) Y
MoCA (Subgroup) Y
Addenbrooke's Cognitive Exam (subgroup) Y

Imaging

Variable type Variables generally collected
Structural T1 Y
Fluid attenuation inversion recovery (FLAIR) Y
Diffusion imaging (DTI/DWI) Y
f-MRI (rest) Y
T2* (T2 Star) Y

Metabolomics

Variable type Variables generally collected
Glucose Y
HbA1c (Repeated collection) Y
Lipids (Repeated collection) Y
Liver Function Tests Y