Cohort Descriptives

Variable Response
Cohort Name UK Biobank
Cohort Acronym UK Biobank
Study Overview UK Biobank aims to assess the relevance of a very wide range of health-related outcomes. It is a large prospective study to investigate the role of genetic factors, environmental exposures and lifestyle in the causes of major diseases of late and middle age. During 2006-2010, UK Biobank conducted its recruitment phase of more than 500,000 participants who gave their consent, answered questions, had physical measurements and gave samples (blood, urine and saliva) at a Baseline assessment visit. Follow-up of their health is now being conducted through medical and other health-related records. Access systems have been developed to facilitate use of the UK Biobank Resource by bona fide researchers for health-related research that is in the public interest.
#Subjects at Baseline 503316
Institution Name UK Biobank
Department Name UK Biobank Coordinating Centre
City Stockport
Study/Database Website

https://www.ukbiobank.ac.uk

Principal Investigator (PI) Professor Sir Rory Collins
PI Address
PI Email

PI Phone
Administrative Contact (AC)
AC Address
AC Email

AC Phone
Technical Contact (TC)
TC Address
TC Email

TC Phone
Key Study References

Please see literature section

Population Based Study? Yes
Family Based Study? No
Clinical based sample? No
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? A combination of in person, postal and internet
Who carries out data collection? Interviewers and clinical staff: Key staff are research nursing and technical staff
Does this take place in participants' homes or at a central location? Home and Central: Baseline visit at central location (office space). Pedometry (100,000) and email questionnaires (300,000) sent to participants and carried out at home. There are additional web based questionnaires that will also be carried out at home.
Do participants take part individually or are families/partners involved? Individually
Dementia cases ascertained as part of study: No
Diagnosis based on review of existing clinical data
Was diagnosis/primary outcomes made blind to exposure variables?
How many times followed up? 2, with online questionnaires at intervals
How regular is follow-up? Subgroups followed up more frequently, with online questionnaires asking about diet, work history, patricipants' thoughts and feelings and cognitive function.
# Subjects at Follow-up 20,000 at repeat assessment, aim of 100,000 at imaging visit
Study start date 1/1/2006 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? No
Inclusion criteria Age 40-69 years at recruitment. Capacity to consent. Lived within 20-25 miles of one of the assessment centres.
Exclusion criteria UK Biobank did not enrol potential participants who express the view that they would want to be withdrawn should they lose mental capacity or die because this would reduce the value of the resource for research.

Administration

Variable type
ID
Date of birth
Sex
Age at recruitment
Reason/date lost to follow-up
Email access
Assessment centre
Date of consenting to join UK Biobank
Home location at assessment

Sociodemographic

Sub-category Variable type Baseline Instance 1 Instance 2 Online Follow-up
Deprivation Accommodation Y Y Y  
Deprivation Household information Y Y Y  
Deprivation Townsend deprivation index at recruitment Y      
Education Age completed full time education Y Y Y  
Education Qualifications Y Y Y  
Employment Current/main job information Y Y Y  
Employment Transport to workplace Y Y Y  
Employment Distance between home and job workplace Y Y Y  
Employment Current employment status Y      
Employment Attendance/disability/mobility allowance Y Y Y  
Ethnicity Year immigrated to UK Y Y Y  
Ethnicity Ethnic background Y      

Family History

Sub-category Variable type Baseline Instance 1 Instance 2 Online Follow-up
Extended Non-accidental death in close genetic family Y Y Y  
Father Father (natural and adopted) Y Y Y  
Mother Mother (natual and adopted) Y Y Y  
Siblings Siblings (natual and adopted) Y Y Y  

Early Life History

Sub-category Variable type Baseline Instance 1 Instance 2 Online Follow-up
Birth Maternal smoking around birth Y Y Y  
Birth Part of a multiple birth Y Y Y  
Birth Adopted as a child Y Y Y  
Birth Birth weight Y Y Y  
Birth Born by caesarian section       Y
Birthplace Country of birth (non-UK) Y      
Birthplace Place of birth (UK) Y Y Y  
Body Size Child Comparative body/height size at age 10 Y Y Y  
Breastfed Breastfed as a baby Y Y Y  
Childhood Environment Long-term antibiotics as a child       Y
Handedness Handedness (chirality/laterality) Y Y Y  

Physical Health Status

Sub-category Variable type Baseline Instance 1 Instance 2 Online Follow-up
Cancer Cancer screenings Y Y Y  
Cancer Physician diagnosed conditions: cancer Y Y Y  
Cancer Physician diagnosed conditions: lung cancer       Y
Cancer Self-reported cancers/non-cancer illnesses Y Y Y  
Cardiothoracic Myocardial infarction     Y  
Cardiothoracic STEMI/NSTEMI     Y  
Cardiothoracic Physician diagnosed conditions: various cardiothoracic conditions Y Y Y  
Cardiothoracic Ischaemic stroke     Y  
Cardiothoracic Intracerebral/subarachnoid haemorrhage     Y  
Digestive Health Physician diagnosed conditions: IBS       Y
Digestive Health Abdominal pain/discomfort       Y
Digestive Health Physician diagnosed conditions: coeliac disease/gluten sensitivity       Y
Digestive Health General gastro-intestinal health       Y
ENT Hearing aid/cochlear implant Y Y Y  
ENT Tinnitus severity/nuisance Y Y Y  
ENT Noisy workplace Y Y Y  
ENT Frequency of loud music exposure Y Y Y  
Eyes Glasses/contact lenses Y Y Y  
Eyes Glaucoma/cataract diagnosed Y Y Y  
Eyes Which eye(s) affected by various eye conditions Y Y Y  
Eyes Eye problems/disorders Y Y Y  
General Health Overall health rating Y Y Y  
General Health Long-standing illness, disability or infirmity Y Y Y  
General Health Falls and resulting fractures Y Y Y  
General Health Weight change compared with 1 year ago Y Y Y  
General Health Physician diagnosed conditions: diabetes/gestational diabetes Y Y Y  
General Health Physician diagnosed conditions: other serious medical condition/disability Y Y Y  
General Health Physician diagnosed conditions: vascular/heart problems Y Y Y  
Mouth Mouth/teeth dental problems Y Y Y  
Pain Body/joint/general pain report Y Y Y  
Respiratory Physician diagnosed conditions: hay fever/rhinitis/eczema Y Y Y  
Respiratory Physician diagnosed conditions: heart attack Y Y Y  
Respiratory Wheeze or whistling in the chest/shortness of breath Y Y Y  

Reproductive History

Sub-category Variable type Baseline Instance 1 Instance 2 Online Follow-up
Female Age when periods started Y Y Y  
Female Menopause Y Y Y  
Female Number of live births Y Y Y  
Female Birth weight of first child Y Y Y  
Female Age at first/last live birth Y Y Y  
Female Stillbirth/spontaneous miscarriage/termination Y Y Y  
Female Oral contraceptive pill Y Y Y  
Female Hormone-replacement therapy (HRT) Y Y Y  
Female Hysterectomy/oophorectomy (both ovaries removed) Y Y Y  
Female Menstrual cycles Y Y Y  
Female Age of primiparous women at birth of child Y Y Y  
Male Relative age of first facial hair Y Y Y  
Male Relative age voice broke Y Y Y  
Male Hair/balding pattern Y Y Y  
Male Number of children fathered Y Y Y  

Healthcare Utilisation

Sub-category Variable type Baseline Instance 1 Instance 2 Online Follow-up
Community Care Frequency of friend/family visits Y Y Y  
Community Care Able to confide Y Y Y  
Community Care Leisure/social activities Y Y Y  
Health Insurance Private healthcare Y Y Y  
Medications Treatments/medications for various illnesses       Y
Medications Vitamin, mineral and other dietary supplements Y Y Y  
Operations Pace-maker Y Y Y  
Surgery Surgery/amputation of toe or leg Y Y Y  
Surgery Major operations Y Y Y  

Psychological Status

Sub-category Variable type Baseline Instance 1 Instance 2 Online Follow-up
Personality Mood/feelings assessment Y Y Y  
Personality Tense/'highly strung' Y Y Y  
Personality Suffer from 'nerves' Y Y Y  
Personality Risk taking Y Y Y  
Sleep Extensive sleep assessment Y Y Y  
Wellbeing General happiness/satisfaction assessment       Y
Wellbeing Belief that own life is meaningful       Y
Wellbeing Neuroticism score     Y  

Mental Health Status

Sub-category Variable type Baseline Instance 1 Instance 2 Online Follow-up
Abuse Felt hated/physically abused by family member as a child       Y
Abuse Felt loved as a child       Y
Abuse Someone to take to doctor when needed as a child       Y
Abuse Physical violence/sexual interference by partner without consent as an adult       Y
Abuse Victim of sexual assault as a child/adult       Y
Addictions Addiction to any substance/behaviour/alcohol/miscellaneous       Y
Addictions Addiction to illicit or recreational drugs/over-the-counter medication       Y
Consultation Ever sought or received professional help for mental distress       Y
Consultation Ever talked to a health professional about unusual or psychotic experiences       Y
Mood Mental health questionnaire       Y
Mood Depression/anxiety       Y
Mood Mania/irritability/anger       Y
Mood Psychotic experiences       Y
Mood Stress       Y
Mood Belittlement by partner or ex-partner as an adult       Y
Mood Been in a confiding relationship as an adult       Y
Mood Unenthusiasm/disinterest Y Y Y  
Mood Illness, injury, bereavement, stress in last 2 years Y Y Y  
Mood Bipolar disorder     Y  
Self Harm Suicide       Y
Self Harm Self-harm       Y
Trauma Able to pay rent/mortgage as an adult       Y
Trauma Traumatic experience (serious accident, combat/war-zone, violent crime/death)       Y
Trauma Diagnosed with life-threatening illness       Y

Cognitive Status

Sub-category Variable type Baseline Instance 1 Instance 2 Online Follow-up
Alzheimer's Physician diagnosed conditions: Alzheimer's disease     Y  
Dementia Physician diagnosed conditions: dementia     Y  
Frontotemporal Dementia Physician diagnosed conditions: frontotemporal dementia     Y  
Parkinson's Physician diagnosed conditions: Parkinson's disease     Y  
Vascular Dementia Physician diagnosed conditions: vascular dementia     Y  

Lifestyle

Sub-category Variable type Baseline Instance 1 Instance 2 Online Follow-up
Alcohol Average weekly/monthly alcohol intake Y Y Y  
Alcohol Alcohol usually taken with meals Y Y Y  
Alcohol Alcohol intake versus 10 years previously Y Y Y  
Alcohol Former alcohol drinker/reason stopped drinking alcohol Y Y Y  
Alcohol Alcohol drinker status Y Y Y  
Alcohol Size of wine glass drunk Y     Y
Diet Fat intake Y     Y
Diet Vitamins/minerals Y     Y
Diet Carbohydrate intake Y     Y
Diet Fruit/vegetable intake Y     Y
Diet Hot drink intake Y     Y
Diet Other drink intake Y     Y
Diet Meat/fish/vegetarian alternative intake Y     Y
Diet Dairy intake Y     Y
Diet Time spent doing physical activity Y     Y
Diet Savoury/sweet snack intake Y     Y
Diet Portion size/typical diet Y     Y
Diet Total sugars Y     Y
Diet Salt added to food Y Y Y Y
Diet Type of special diet followed Y     Y
Diet Spreads/sauces intake Y     Y
Diet Extensive diet questionnaires completed Y     Y
Physical Walking Y Y Y  
Physical Moderate/vigorous activity Y Y Y  
Physical Other activity/exercise Y Y Y  
Physical Time spent watching TV/using computer Y Y Y  
Physical Driving/other transport Y Y Y  
Sexual Sexual history Y Y Y  
Smoking Smoking history Y Y Y  
Substances History of alcohol/substances intake       Y

Physical Environment

Sub-category Variable type Baseline Instance 1 Instance 2 Online Follow-up
Housing Date first recorded at location     Y  
Housing Home location & area population density     Y  
Sun Exposure Time spent outdoors in summer/winter Y Y Y  
Sun Exposure Skin colour/ease of tanning/sunburn occasions Y Y Y  
Sun Exposure Hair colour (natural, before greying) Y Y Y  
Sun Exposure Facial ageing Y Y Y  
Sun Exposure Use of sun/uv protection Y Y Y  
Sun Exposure Frequency of solarium/sunlamp use Y Y Y  
Work Devices used at work       Y
Work Year ended full time education       Y
Work Job information       Y
Work Work hours       Y
Work Workplace conditions       Y
Work Breathing problems/frequent cough due to workplace/job       Y
Work Shift work (day/night)       Y
Work Gap periods       Y
Work Physician diagnosed conditions: various lung diseases/illnesses       Y
Work Tobacco smoking in the work place       Y

Social Environment

Sub-category Variable type Baseline Instance 1 Instance 2 Online Follow-up
Multimedia Mobile phone use Y Y Y  
Multimedia Hands-free device/speakerphone use in last 3 months Y Y Y  
Multimedia Difference in mobile phone use compared to two years previously Y Y Y  
Multimedia Usual side of head for mobile phone use Y Y Y  
Multimedia Plays computer games Y Y Y  

Physical Examination

Sub-category Variable type Baseline Instance 1 Instance 2 Online follow-up
Anthropometry Impedance of limbs, whole body Y Y Y  
Anthropometry Weight Y Y Y  
Anthropometry Whole body fat mass/percentage Y Y    
Anthropometry Whole body water mass Y Y    
Anthropometry Body mass index (BMI) Y Y    
Anthropometry Basal metabolic rate Y Y    
Anthropometry Height (standing, seated) Y Y Y  
Anthropometry Waist/hip circumference Y Y Y  
Ear Extensive hearing assessments Y Y Y  
Eye Extensive eye/sight assessments Y Y    
Eye Glasses worn/required Y Y    
Eye Ever had eye surgery Y Y    
Eye Current eye infection Y Y    
Heart ECG assessments Y Y    
Heart Cardiac assessments Y Y Y  
Lung Extensive lung assessments Y Y Y  
Lung Caffeine drank within last hour Y Y Y  
Lung Used an inhaler for chest within last hour Y Y Y  
Lung Smoked cigarette or pipe within last hour Y Y Y  
Strength Hand grip strength Y Y Y  

Linkage Data

Sub-category Variable type Baseline Instance 1 Instance 2 Online Follow-up
Cancer Register Cancer diagnosis   Y    
Death Register Date of/age at death   Y    
HES Spell and episode data   Y    
HES Patient classification on admission   Y    
HES Main/treatment speciality of consultant   Y    
HES Inpatient record format     Y  
HES PCT where patients GP was registered   Y    
HES Administrative and legal statuses   Y    
HES Admissions/discharges from hospital   Y    
HES Intended management of patient   Y    
HES External causes   Y    
HES Diagnoses   Y    
HES Operative procedures   Y Y  

Biosample Assays

Sub-category Variable type Baseline Instance 1 Instance 2 Online follow-up
Biochemistry Saliva samples Y Y    
Biochemistry Urine samples Y Y    
Haematology Blood cell counts (red/white) Y Y Y  
Haematology Haemoglobin concentration/percentage Y Y Y  
Haematology Mean corpuscular volume/haemoglobin Y Y Y  
Haematology Platelet analyses Y Y Y  
Haematology Analyses of various types of white blood cell Y Y Y  
Haematology Analyses of various types of red blood cell Y Y Y  
Haematology Mean sphered cell volume tests Y Y Y  
Haematology Blood samples Y Y Y  
Haematology Analyses of blood components Y Y Y  

Digital Phenotyping

Sub-category Variable type Baseline Instance 1 Instance 2 Online Follow-up
Accelerometer Acceleration average/standard deviation     Y  
Accelerometer Calibration of data     Y  
Accelerometer Fraction acceleration     Y  
Accelerometer Accelerometer administrative data        
Accelerometer Data recording errors     Y  
Accelerometer Wear duration during each day/hour of the week     Y  
Cognitive Performance Willing to attempt cognitive tests Y Y Y  
Cognitive Performance Aide-memoire completed Y Y    
Cognitive Performance Number/history of attempts Y Y Y  
Cognitive Performance Pairs matching       Y
Cognitive Performance Fluid intelligence       Y
Cognitive Performance Numeric memory       Y
Cognitive Performance Trail making       Y
Cognitive Performance Symbol digit substitution       Y

Imaging

Sub-category Variable type Baseline Instance 1 Instance 2 Online Follow-up
BMD Various body part measurements Y Y Y  
BMD DXA scans     Y  
BMD Android measurements     Y  
BMD VAT (visceral adipose tissue) mass & volume     Y  
BMD L1-L4 measurements     Y  
MRI FA skeleton MRI     Y  
MRI Brain MRI     Y  
MRI tfMRI (task-based functional MRI)     Y  
MRI rfMRI (resting-state functional MRI)     Y  
MRI T1/T2 MRI     Y  
MRI Abdominal MRI     Y  
MRI Cardiac MRI     Y  

Genomics

Sub-category Variable type Baseline Instance 1 Instance 2 Online Follow-up
Genotyping Chromosome genotype probabilities/intensities     Y  
Genotyping Mitochondrial genotype probabilities/intensities     Y  
Genotyping Genotype measurement batch/plate/well     Y  
Genotyping Genetic sex     Y  
Genotyping Genetic ethnic grouping     Y  
Genotyping Genetic principal components     Y  
Genotyping Genetic kinship to other participants     Y  
Genotyping DNA concentration     Y  
Genotyping Recommended genomic analysis exclusions     Y  
Genotyping Genetic relatedness     Y  
Genotyping UKBiLEVE Affymetrix/genotype quality control for samples     Y  
Genotyping UKBiLEVE unrelatedness indicator     Y  
Genotyping Extensive genotyping        

Built Environment

Sub-category Variable type Baseline Instance 1 Instance 2 Online Follow-up
Air Pollution Nitrogen oxides air pollution     Y  
Air Pollution Particulate matter air pollution     Y  
Air Pollution Traffic intensity/loads on nearest roads     Y  
Air Pollution Close to major road     Y  
Air Pollution Sum of road length of major roads within 100m     Y  
Greenspace Greenspace/domestic garden percentage Y Y    
Morphometrics Natural environment percentage Y Y    
Noise Pollution Average sound level of noise pollution     Y  
Water Water percentage Y Y    
Water Distance (Euclidean) to coast Y Y