Cohort Descriptives

Variable Response
Cohort Name Samsung Medical Center Amyloid PET Cohort
Cohort Acronym SMC Amyloid PET
DOI Won Seo, S. (2018). SMC Amyloid PET [Data set]. Dementias Platform UK. https://doi.org/10.48532/044000
Study Overview To verify the predictive effect of amyloid-pathology (amyloid-PET imaging) and biomarkers from the subjects who had been followed up for more than 5 years.
#Subjects at Baseline 120
Institution Name Samsung Medical Center
Department Name Department of Neurology
City Seoul, Korea
Principal Investigator (PI) Sang Won Seo
Key Study References

Please see Literature section

Population Based Study? Yes
Family Based Study? No
Clinical based sample? Yes
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? In person: Data is collected at Dementia Center in Samsung Medical Center.
Who carries out data collection? Intervewers and Clinicians: Researchers including Researching Doctor and Researcher.
Does this take place in participants' homes or at a central location? Central: Samsung Medical Center
Do participants take part individually or are families/partners involved? Individually
Dementia cases ascertained as part of study: Yes
Diagnosis based on review of existing clinical data Yes
Was diagnosis/primary outcomes made blind to exposure variables? Yes
How many times followed up? 1
# Subjects at Follow-up 120
Study start date 15/01/2016 00:00:00
Is study ongoing? No
Is study still recruiting? No
Inclusion criteria Community dwelling people: Cognitively normal. SMC clinic patients: Serious Mental Illness (SMI), Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD).

Administration

Variable type
Age Of Patient
Date Of Amyloid PET
Date Of Birth
Date Of Blood Collection
Date Of Physical Examination
Date Of Survey
Institution Name
Patient ID
Sex Of Patient
Whether Fasted For Blood Collection

Sociodemographic

Sub-category Variable type Baseline 1
Education Years of education Y Y

Family History

Sub-category Variable type Baseline 1
Extended Family history of dementia Y Y
Father Dementia history of father   Y
Gparents Dementia history of grandparents   Y
Mother Dementia history of mother   Y
Siblings Dementia history of brother   Y
Siblings Dementia history of sister   Y

Early Life History

Sub-category Variable type Baseline 1
Handedness Handedness   Y

Physical Health Status

Sub-category Variable type Baseline 1
Cancer Any cancer Y Y
Cardiothoracic Anaemia Y Y
Cardiothoracic Diyslipidemia Y Y
Cardiothoracic High blood pressure/hypertension (HiBP/HTN) Y Y
Cardiothoracic Other cardiovascular diseases Y Y
Cerebrovascular Stroke Y Y
Endocrinology Thyroid disease Y Y
Gastrointestinal Chronic gastrointestinal disease Y Y
General Health Diabetes Y Y
General Health Encephalitis/meningitis Y Y
General Health Fractures (limb/spinal compression/other) Y Y
General Health Kidney/liver disease Y Y
General Health Loss of consciousness Y Y
General Health Mental retardation Y Y
General Health Other medical conditions Y Y
General Health Syphilis Y Y
Neurological Brain damage/tumour Y Y
Neurological Epilepsy Y Y
Neurological Traumatic brain injury (TBI)   Y
Respiratory Carbon monoxide (CO) poisoning Y Y
Respiratory Lung disease Y Y
Respiratory Pulmonary disease   Y
Rheumatology Arthritis Y Y

Healthcare Utilisation

Sub-category Variable type Baseline 1
Medications Treatment of alcoholism   Y
Medications Treatment of arthritis   Y
Medications Treatment of cancer   Y
Medications Treatment of cardiovascular conditions   Y
Medications Treatment of chronic gastrointestinal disease   Y
Medications Treatment of dementia   Y
Medications Treatment of depression   Y
Medications Treatment of diabetes   Y
Medications Treatment of encephalitis/meningitis   Y
Medications Treatment of fractures (limb/spinal compression/other)   Y
Medications Treatment of kidney/liver disease   Y
Medications Treatment of neurological conditions   Y
Medications Treatment of other conditions   Y
Medications Treatment of respiratory conditions   Y
Medications Treatment of syphilis   Y
Medications Treatment of thyroid disease   Y
Medications Whether taking medicine   Y
Surgery Brain surgery Y Y

Life Functionality

Sub-category Variable type Baseline 1
Daily Living Basic Activities of Daily Living (B-ADL) Y Y
Daily Living Korean Instrumental Activities of Daily Living (K-IADL) Y Y

Psychological Status

Sub-category Variable type Baseline 1
Sleep Sleep disorder Y Y

Mental Health Status

Sub-category Variable type Baseline 1
Disorders Diagnosed with serious mental illness (SMI)   Y
Disorders Mental disorder Y Y
Mood Depression Y Y
Mood Geriatric Depression Scale   Y
Mood Short version of Geriatric Depression Scale   Y

Cognition

Sub-category Variable type Baseline 1
Cognitive Performance Clock Drawing test (CDT) Y Y
Cognitive Performance Controlled Oral Word Association Test (COWAT) Y Y
Cognitive Performance Digit span (forward/backward) Y Y
Cognitive Performance Digit Symbol Coding test (DSC) Y Y
Cognitive Performance Frontal lobe function tests Y Y
Cognitive Performance Korean Colour-Word Stroop test (K-CWST) Y Y
Cognitive Performance Korean Trail Making Test (KTMT) Y Y
Cognitive Performance Korean version of Mini Mental State Examination (K-MMSE) Y Y
Cognitive Performance Korean-Boston Naming Test (K-BNT) Y Y
Cognitive Performance Letter cancellation Y Y
Cognitive Performance Reading/writing/calculations Y Y
Cognitive Performance Rey Complex Figure Test (RCFT) Y Y
Cognitive Performance Seoul Neuropsychological Screening Battery 2nd edition (SNSB-II) Y Y
Cognitive Performance Seoul Verbal Learning Test (SVLT) Y Y
Cognitive Performance SNSB-C Y Y
Cognitive Performance Speech tests Y Y
Cognitive Status Clinical Dementia Rating - Sum of Boxes (CDR-SOB) Y Y
Cognitive Status Clinical Dementia Rating (CDR) Y Y
Cognitive Status Date of dementia diagnosis   Y
Cognitive Status Global Deterioration Scale (GDS) Y Y
Cognitive Status Type of dementia diagnosis   Y
Self Report Cognitive Status Age at onset of cognitive decline   Y

Lifestyle

Sub-category Variable type Baseline 1
Alcohol Alcoholism/alcohol abuse Y Y
Alcohol History of alcohol intake   Y
Smoking History of smoking   Y
Smoking Number of packs smoked per year (past/present)   Y
Substances Drug abuse Y Y

Physical Examination

Sub-category Variable type Baseline 1
Anthropometry BMI Y Y
Anthropometry Height Y Y
Anthropometry Weight Y Y
Heart Blood pressure Y Y
Heart Heart rate Y Y

Biosample Assays

Sub-category Variable type Baseline 1
Biochemistry Alanine transaminase (ALT/SGPT) Y Y
Biochemistry Albumin Y Y
Biochemistry Alkaline phosphatase (ALP) Y Y
Biochemistry Aspartate transaminase (AST/SGOT) Y Y
Biochemistry Blood urea nitrogen (BUN) Y Y
Biochemistry Creatinine Y Y
Biochemistry Gamma-glutamyl transferase (r-GT) Y Y
Biochemistry Glucose(s) Y Y
Biochemistry HDL/LDL cholesterol Y Y
Biochemistry Lactate dehydrogenase (LDH) Y Y
Biochemistry Total bilirubin Y Y
Biochemistry Total cholesterol Y Y
Biochemistry Total protein Y Y
Biochemistry Triglyceride Y Y
Haematology Complete blood count Y Y
Haematology Mean corpuscular haemoglobin (MCH) Y Y
Haematology Mean corpuscular haemoglobin concentration (MCHC) Y Y
Haematology Mean corpuscular volume (MCV) Y Y

Genomics

Sub-category Variable type Baseline 1
APOE APOE genotype   Y