Cohort Descriptives

Variable Response
Cohort Name Platform for Research Online To investigate gEnetics and CogniTion and ageing
Cohort Acronym PROTECT
Study Overview The PROTECT Study is an online-based project that gathers research to improve understanding of the ageing brain and why some people develop dementia. Participants in PROTECT provide information such as demographics and lifestyle and complete online assessments to cognitive abilities. By repeating these assessments each year the study team are able to monitor change over the study. Participants also provide a sample of their DNA through a simple at-home kit.
#Subjects at Baseline 14000
Institution Name King's College London
Department Name Institute of Psychiatry, Psychology and Neuroscience
City London
Study/Database Website

http://www.protectstudy.org.uk/

Principal Investigator (PI) Dr Anne Corbett
Key Study References

Please see Literature section

Population Based Study? Yes
Family Based Study? No
Clinical based sample? No
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? Internet
Does this take place in participants' homes or at a central location? Home
Do participants take part individually or are families/partners involved? Individually
Dementia cases ascertained as part of study: No
Diagnosis based on review of existing clinical data No
Was diagnosis/primary outcomes made blind to exposure variables? No
Study start date 4/1/2014 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? Yes
Inclusion criteria Aged 50 or over. Resident in the United Kingdom. Have not been diagnosed with dementia.
Exclusion criteria Unable to consent. Established diagnosis of dementia.

Administration

Variable type Variables generally collected
Study ID Y
Age Y
Sex Y

Sociodemographic

Variable type Variables generally collected
Age Y
Age at last follow-up Y
Sex Y
Ethnicity Y
Level of education Y
Employment Status Y

Physical Health Status

Variable type Variables generally collected
Cancer (if self-reported) Y
Diabetic Status (if self-reported) Y

Life Functionality

Variable type Variables generally collected
Lawton IADL Y

Mental Health Status

Variable type Variables generally collected
Anxiety measure Y

Lifestyle

Variable type Variables generally collected
Smoking Y
Current smoking Y
Former smoking Y
Alcohol Y
Alcohol Use Disorders Identification Test (AUDIT) Y
Binge drinking Y
Drugs of abuse assessment Y
Physical activity and exercise Y
Type of exercise: heavy, light Y
Diet Y

Physical Environment

Variable type Variables generally collected
Living situation Y

Physical Examination

Variable type Variables generally collected
BMI Y
Weight (self-report, assessed before onset of dementia) Y
Height (self-report, assessed before onset of dementia) Y

Biosample Assays

Variable type Variables generally collected
RNA Y
DNA (Saliva) Y
Saliva collected Y

Digital Phenotyping

Variable type Variables generally collected
Visual memory Y
Reaction time Y
Associative learning Y
Language Y
Vigilance Y

Genomics

Variable type Variables generally collected
GWAS platform Y