Cohort Descriptives

Variable Response
Cohort Name Parkinsonism: Incidence and CogNItive heterogeneity in CambridgeShire
Cohort Acronym PICNICS
Study Overview The PICNICS study is an observational incidence study tracking the progression of patients with Parkinson’s disease over several years to better understand how the disease behaves over time, and establish the pattern of evolution of subtypes of Parkinson’s disease. Understanding differences between subtypes and what drives them will inform development of stratified therapies. The study recruited patients with Parkinson’s disease between 2008 and 2013, and is following them up every 18 months with clinical assessments, cognitive assessments and biological sampling
#Subjects at Baseline 290 subjects
Institution Name University of Cambridge
Department Name Clinical Neurosciences, John van Geest Centre for Brain Repair
City Cambridge
Study/Database Website

http://thebarkerlab.co.uk/parkinsons-disease/

Principal Investigator (PI) Prof Roger Barker
Population Based Study? Yes
Family Based Study? No
Clinical based sample? Yes
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? In person
Who carries out data collection? Interviewers and clinicians
Does this take place in participants' homes or at a central location? Central: Assessments can be done at home if travel is difficult for the participant
Do participants take part individually or are families/partners involved? Individually
Dementia cases ascertained as part of study: Yes
Diagnosis based on review of existing clinical data Yes
Study start date 1/15/2008 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? No
Inclusion criteria Adults over 18 New onset Parkinson's disease meeting UKPDS Brain Bank Criteria Resident in Cambridgeshire
Exclusion criteria Dementia diagnosis at baseline

Administration

Variable type Variables generally collected
Study ID Y
Age Y
Sex Y

Sociodemographic

Variable type Variables generally collected
Age Y
Age at time of diagnosis of dementia Y
Age at last follow-up Y
Age at time of death Y
Sex Y
Ethnicity Y
Education Y
Employment status Y

Physical Health Status

Variable type Variables generally collected
Cardiovascular disease data (From clinical records) Y
Myocardial infarction (From clinical records) Y
Cancer (From clinical records) Y
Diabetic Status (From clinical records) Y

Healthcare Utilisation

Variable type Variables generally collected
Medication use Y

Life Functionality

Variable type Variables generally collected
PDQ39 (PD specific) (Repeated collection) Y
UPDRS (PD specific) (Repeated collection) Y
Hoehn and Yahr (PD specific) (Repeated collection) Y

Mental Health Status

Variable type Variables generally collected
Beck Depression Inventory Y
NPI Y
Apathy evaluation Y

Cognitive Status

Variable type Variables generally collected
Parkinson's Disease Y
MCI Y

Lifestyle

Variable type Variables generally collected
Smoking Y
Current smoking Y
Former smoking Y

Physical Environment

Variable type Variables generally collected
Living situation Y

Physical Examination

Variable type Variables generally collected
Neurological examination (assessed before onset of dementia) Y
Gait assessment (assessed before onset of dementia) (part of UPDRS) Y

Linkage Data

Variable type Variables generally collected
Myocardial infarction (from clinical records) Y
Cancer (from clinical records) Y
Diabetic status (from clinical records) Y

Biosample Assays

Variable type Variables generally collected
DNA (blood collected) Y

Digital Phenotyping

Variable type Variables generally collected
Visual memory Y
Visuospatial Function Y
Associative Learning Y
Language Y
Verbal fluency Y
Working memory Y
Spatial Recognition Memory (SRM) Y
IQ data Y
NART Y
MMSE (Repeated collection) Y
Addenbrooke's Cognitive Exam (Repeated collection) - ACE-R. Y

Genomics

Variable type Variables generally collected
Gene screening: MAPT Y