Cohort Descriptives

Variable Response
Cohort Name The Incidence of Cognitive Impairment in Cohorts with Longitudinal Evaluation-PD
Cohort Acronym ICICLE-PD
DOI Burn, D. (2017). ICICLE-PD [Data set]. Dementias Platform UK. https://doi.org/10.48532/029000
Study Overview The ICICLE-PD study aims to accurately characterise two independent cohorts of incident parkinsonsim in Newcastle-Gateshead and Cambridgeshire. A key objective is to identify patients who develop PD Dementia and the factors that predict its evolution. From this information, a simplified panel of tests that can be used to predict PDD will be established. ICICLE-PD will therefore provide a platform for studies investigating agents designed to help treat this complication of PD. Longitudinal follow up is on-going with assessments at 18 month intervals.
#Subjects at Baseline 219 with PD and 99 controls (318 total)
Institution Name Newcastle University
Department Name Clinical Ageing Research Unit
City Newcastle
Study/Database Website

http://bam-ncl.co.uk/our-work/studies/icicle-pd/

Principal Investigator (PI) Professor David Burn
Key Study References

Please see Literature section

Population Based Study? No
Family Based Study? No
Clinical based sample? Yes
Is there follow-up data available? No
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? In person
Who carries out data collection? Interviewers and Clinicians
Does this take place in participants' homes or at a central location? Central
Do participants take part individually or are families/partners involved? Individually
Dementia cases ascertained as part of study: Yes
Diagnosis based on review of existing clinical data Yes
Was diagnosis/primary outcomes made blind to exposure variables? No
How many times followed up? 5
Study start date 6/1/2009 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? No
Inclusion criteria PD: Newly diagnosed PD based in Newcastle upon Tyne/Gateshead and Cambridgeshire. Control: Aged 45+, no known cerebral disease/abnormality, ability to travel for scans, English as first language or fluent, ability to move without walking aid, no cognitive impairment, movement disorder or current significant mood disorder.
Exclusion criteria PD: Suspected parkinsonism prior to onset of study, no working knowledge of English, significant memory impairment at presentation, no capacity to consent, DLB. Drug-induced parkinsonism, vascular parkinsonism, progressive supranuclear palsy, multiple system atrophy, corticolbasal degeneration. Control: MMSE <24 or dementia, significant vascular co-morbidity, no capacity to consent.

Administration

Variable type
Age At First Assessment
Date Of First Assessment
Newcastle/Cambridge Group
Participant ID
Sex Of Participant

Sociodemographic

Sub-category Variable type Baseline
Education Number of years of completed education Y

Physical Health Status

Sub-category Variable type Baseline
Cardiothoracic Hypercholesterolaemia Y
Cardiothoracic Hypertension Y
Cardiothoracic Ischaemic heart disease Y
Cerebrovascular Stroke Y
ENT Smell or taste Y
Eyes Double vision Y
General Health Diabetes (Type I/II) Y
General Health Non-Motor Symptom assessment scale for Parkinson's Disease (NMS-Quest) Y
Pain Pain location and duration Y

Healthcare Utilisation

Sub-category Variable type Baseline
Medications Dopamine agonist use Y
Medications Frequency and dosages Y
Medications Levodopa equivalent daily dose Y
Medications Medication name Y
Medications Other medication Y
Medications Parkinson's specific medication usage Y

Life Functionality

Sub-category Variable type Baseline
Daily Living Unified Parkinson's Disease Rating Scale (UPDRS) - part 2 Y

Psychological Status

Sub-category Variable type Baseline
Sleep Epworth Sleepiness Scale Y
Sleep Non-Motor Symptom assessment scale for Parkinson's Disease (NMS-Quest) - Sleep specific questions Y
Sleep Pittsberg Sleep Quality Index Y

Mental Health Status

Sub-category Variable type Baseline
Disorders Non-Motor Symptom assessment scale for Parkinson's Disease (NMS-Quest) - Psychosis specific questions Y
Mood Geriatric Depression Scale (15 item version) Y
Mood Non-Motor Symptom assessment scale for Parkinson's Disease (NMS-Quest) - Mood specific questions Y

Cognition

Sub-category Variable type Baseline
Cognitive Performance Alternative pentagon score Y
Cognitive Performance Digit vigilance tests, from Cognitive Drug Research Battery Y
Cognitive Performance Mini Mental State Examination score Y
Cognitive Performance Montreal Cognitive Assessment score Y
Cognitive Performance National Adult Reading Test score Y
Cognitive Performance One Touch Stockings test from CANTAB Y
Cognitive Performance Reaction time tests, from Cognitive Drug Research Battery Y
Cognitive Performance Various spatial/paired memory tests, from CANTAB Y
Cognitive Performance Verbal fluency tests (phonemic and semantic) Y
Cognitive Status Duration of PD symptoms in months Y
Cognitive Status Hoehn and Yahr scale, PD severity score Y
Cognitive Status Number of days/months since Parkinson's diagnosis Y

Lifestyle

Sub-category Variable type Baseline
Alcohol Number of units of alcohol consumed per week Y
Sexual Sexual activity and function Y
Smoking Current smoking status Y

Physical Examination

Sub-category Variable type Baseline
Anthropometry Body Mass Index (BMI) Y
Anthropometry Height in m Y
Anthropometry Weight in kg Y
Mobility Dyskinesias present? Y
Mobility Motor phenotype Y
Mobility Movement Disorder Society Unified Parkinson's disease rating scale Part III (motor severity score) Y
Mobility UPDRS part III movement tests Y

Biosample Assays

Sub-category Variable type Baseline
Biochemistry BuChE amino acids/base pairs Y
Biochemistry COMT amino acids/base pairs Y
Biochemistry EGF amino acids/base pairs Y
Biochemistry LRRK2 amino acids/base pairs Y

Imaging

Sub-category Variable type Baseline
MRI fMRI Y
MRI T1-weighted MRI Y
PET FDG-PET Y

Genomics

Sub-category Variable type Baseline
APOE APOE base pairs Y
Genotyping MAPT base pairs/genotype Y
Genotyping SNCA base pairs Y