Cohort Descriptives

Variable Response
Cohort Name Hong Kong University Neurocognitive Disorder Cohort
Cohort Acronym HKUNCDC
Study Overview The HKU Neurocognitive Disorder (NCD) Cohort is a hospital-based, prospective, observational study of older HK Chinese adults with cognitive impairment, with a special focus on those with subjective cognitive decline and mild cognitive impairment. Comprehensive profiling of each subject is performed through a multi-domain assessment protocol including detailed demographics, lifestyle factors, neuropsychological battery, mood, MRI, genetics, blood biomarkers, and other patient-centred parameters including level of disability, quality of life and societal engagement. Ongoing annual follow up captures the essential clinical events and changes in neurocognitive function (conversion to MCI or dementia), mood, level of disability and quality of life, as well as repeat blood tests. The HKU NCD Cohort is the first-ever Asian dementia cohort to be formally included into the Dementia Platforms UK, achieving an international collaborative status with other UK-based cohorts. The study neuropsychological battery is aligned with the NACC UDS3 battery.
Institution Name The University of Hong Kong
Department Name Department of Medicine
City Hong Kong
Principal Investigator (PI) Dr Joseph SK Kwan
Population Based Study? No
Family Based Study? No
Clinical based sample? Yes
Is there follow-up data available? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? In person: Patients are recruited from the Memory Clinic and General Geriatrics Specialist Outpatient Clinic in Queen Mary Hospital. Clinical diagnosis is made by the PI and Senior Physician. Upon receiving informed consent, the participant underwent baseline face-to-face assessments by the research assistants, and blood test.
Who carries out data collection? Clinicians. Clinical staff: Trained research assistants
Does this take place in participants' homes or at a central location? Central: Queen Mary Hospital, HKU, HK
Do participants take part individually or are families/partners involved? Family: Families/partners involved
Dementia cases ascertained as part of study: Yes
Diagnosis based on review of existing clinical data Yes
Was diagnosis/primary outcomes made blind to exposure variables? No
How many times followed up? Annual
Study start date 9/1/2014 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? Yes
Inclusion criteria Older adults with or without neurocognitive disoder. HKU NCD Cohort focuses primarily on people with Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI).
Exclusion criteria Severe Parkinson's disease, major depressive disorder or severe psychiatric conditions, significant communication difficulties (e.g. aphasia, deafness), terminal cancer or likely end-of-life in the next 12 months.

Administration

Variable type Variables generally collected
Study ID Y
Age Y
Sex Y

Sociodemographic

Variable type Variables generally collected
Age Y
Age at last follow-up Y
Sex Y
Ethnicity Y
Years of education Y
Level of education Y
Employment status Y

Physical Health Status

Variable type Variables generally collected
Cardiovascular disease data Y
Myocardial infarction Y
Medication use for CVD Y
Hypertension Y
Systolic/diastolic BP Y
Hypercholesterolemia Y
Cancer Y
Diabetic Status Y
Stroke data Y
Transient Ischemic Attack Y
Head trauma: Loss of consciousness Y
Head trauma severity Y

Health Care Utilisation

Variable type Variables generally collected
Medication use Y
Medication use for CVD Y
Hospital utilisation Y
Admission to nursing home Y

Life Functionality

Variable type Variables generally collected
Functional Assessment Questionniare (FAQ) Y
Barthel Index (20-point) Y
FAST Y
Lawton IADL (Lawton IADL max 8 points) Y

Psychological Status

Variable type Variables generally collected
Quality of Life-Alzheimers Disease (QOL-AD) Y
Quality of life of caregivers (CQOL) Y
Sleep assessment Questionnaires (from Sept 2017) Y
Insomnia Severity Index Y

Mental Health Status

Variable type Variables generally collected
Geriatric Depression Scale (GDS) Y
NPI Y
NPI-Q Y

Cognitive Status

Variable type Variables generally collected
Alzheimer's dementia Y
Lewy Body Disease Y
Huntington's Disease Y
Parkinson's Disease Y
Frontotemporal dementia Y
Vascular dementia Y
MCI Y
Subjective complaint Y

Lifestyle

Variable type Variables generally collected
Smoking Y
Current smoking Y
Former smoking Y
Alcohol Y
Units per day/week vs weekend Y
Physical activity and exercise Y
Type of exercise: heavy, light Y
Exercise duration Y
Mini Nutrition Assessment (MNA) Short Form Y

Physical Environment

Variable type Variables generally collected
Living situation Y

Physical Examination

Variable type Variables generally collected
Blood pressure Y
Weight Y
Height Y
Neurological examination Y
Extrapyramidal symptoms Y
Heart rate Y
Gait assessment Y
Waist circumference Y
Hand grip strength Y
Walking speed Y
Frailty status (FRAIL scale) Y
BMI Y
Hip/waist circumference Y

Biosample Assays

Variable type Variables generally collected
Plasma Y
Serum Y
RNA Y
Abeta 1-40 Y
Abeta x-40 Y
Abeta x-42 Y

Digital Phenotyping

Variable type Variables generally collected
Verbal memory Y
Language Y
Modified Boston Naming Test Y
Vigilance Y
Coloured Trail Making Task Y
Benson's complex figure copy and recall Y
MMSE Y
MoCA (HK-MoCA) Y
Abbreviated Mental Test (AMT) Y
Clinical Dementia Rating Scale (CDR) Y
NACC UDS3 forms Y

Imaging

Variable type Variables generally collected
Structural T1 Y
Fluid attenuation inversion recovery (FLAIR) Y
Diffusion imaging (DTI/DWI) Y
f-MRI (rest) Y
PET (Amyloid PET (Selected patients)) Y
In vivo Spectroscopy Y
ASL Y
Retinal imaging: Ocular CT (Selected patients) Y

Metabolomics

Variable type Variables generally collected
eGFR (estimated Glomular Filtration Rate) Y
Glucose Y
HbA1c Y
Lipids Y
Serum creatinine Y
Folate Y
Triglycerides Y
HCT Y
Platelet Y
Calcium Y
B12 Y
T4 Y
TSH Y
VDRL +/- Y