GERAD Cohort - DPUK Data Portal

Cohort Descriptives

Variable	Response
Cohort Name	Genetic and Environmental Risk in Alzheimer’s Disease (GERAD) Consortium
Cohort Acronym	GERAD
#Subjects at Baseline	10,000+
Institution Name	Cardiff University
City	Cardiff
Principal Investigator (PI)	Prof. Julie Williams and colaborators
Population Based Study?	Yes
Is there follow-up data available?	Yes
Were participants included prior to development of dementia (may refer to controls only)?	Yes
Were participants included prior to development of dementia (may refer to controls only)?	Yes
Who carries out data collection?	Researchers and Clinicians
Does this take place in participants' homes or at a central location?	Both Home and Centrally
Dementia cases ascertained as part of study:	Yes
Diagnosis is based on review of existing clinical data:	Yes

Administration

Sub-category	Variable type	Variables generally collected
	Study ID	Y
	Age	Y
	Sex	Y

Sociodemographic

Sub-category	Variable type	Variables generally collected
	Age	Y
	Age at time of diagnosis of dementia (Some-We hold age at onset rather than age at diagnosis)	Y
	Age at last follow-up is not available but can be calculated	Y
	Sex	Y
	Ethnicity	Y
	Years of education	Y
	Level of education	Y
	Employment status	Y

Physical Health Status

Sub-category	Variable type	Variables generally collected
	Cardiovascular disease data	Y
	Myocardial infarction	Y
	Medication use for CVD	Y
	Hypertension	Y
	Systolic/Diastolic BP (Some participants)	Y
	Virus testing	Y
	Cancer	Y
	Diabetic Status	Y
	Stroke data	Y
	Transient Ischemic Attack	Y
	Head trauma data: Loss of consciousness	Y

Health Care Utilisation

Sub-category	Variable type	Variables generally collected
	Medication use	Y
	Medication use for CVD	Y
	Admission to nursing home	Y

Life Functionality

Sub-category	Variable type	Variables generally collected
	ADCS-ADL	Y
	Blessed Dementia Scale	Y
	Global Deterioration Scale (GDS)	Y

Mental Health Status

Sub-category	Variable type	Variables generally collected
	Cornell depression Scale	Y
	Geriatric Depression Scale (GDS)	Y
	NPI	Y
	Apathy evaluation	Y
	Anxiety measure	Y

Cognitive Status

Sub-category	Variable type	Variables generally collected
	Alzheimer's dementia	Y
	Lewy Body disease	Y
	Parkinson's disease	Y
	Frontotemporal dementia	Y
	Vascular dementia	Y
	MCI	Y

Lifestyle

Sub-category	Variable type	Variables generally collected
	Smoking	Y
	Current smoking	Y
	Former smoking	Y
	Alcohol	Y
	Abstainers/former users	Y
	Binge drinking	Y

Physical Environment

Sub-category	Variable type	Variables generally collected
	Living situation	Y

Physical Examination

Sub-category	Variable type	Variables generally collected
	Blood pressure (Some participants)	Y
	Weight (Some participants)	Y
	Height (Some participants)	Y
	Neurological examination (Some)	Y

Digital Phenotyping

Sub-category	Variable type	Variables generally collected
	Verbal Memory	Y
	Language	Y
	Vigilance	Y
	Latent Memory	Y
	Visuospatial function	Y
	IQ data	Y
	NART	Y
	MMSE	Y
	MoCA (Some participants)	Y
	ADAS-Cog (Some participants)	Y
	Addenbrooke's Cognitive Exam (Some participants)	Y
	TICs (Some participants)	Y
	DRS-2 (Some participants)	Y
	Clinical dementia rating scale (CDR)	Y

Biosample Assays

Sub-category	Variable type	Variables generally collected
	Urine	Y

Genomics

Sub-category	Variable type	Variables generally collected
	GWAS	Y
	Whole Exome sequenced	Y
	APOE genotyped	Y
	APOE gene screening	Y
	TREM2 gene screening (some participants)	Y

Metabolomics

Sub-category	Variable type	Variables generally collected
	CRP (c-reactive protein)	Y
	Glucose	Y
	HbA1c	Y
	Lipids	Y