Cohort Descriptives

Variable Response
Cohort Name Genetic and Environmental Risk in Alzheimer’s Disease (GERAD) Consortium
Cohort Acronym GERAD
#Subjects at Baseline 10,000+
Institution Name Cardiff University
City Cardiff
Principal Investigator (PI) Prof. Julie Williams and colaborators
Population Based Study? Yes
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Who carries out data collection? Researchers and Clinicians
Does this take place in participants' homes or at a central location? Both Home and Centrally
Dementia cases ascertained as part of study: Yes
Diagnosis is based on review of existing clinical data: Yes

Administration

Sub-category Variable type Variables generally collected
Study ID Y
Age Y
Sex Y

Sociodemographic

Sub-category Variable type Variables generally collected
Age Y
Age at time of diagnosis of dementia (Some-We hold age at onset rather than age at diagnosis) Y
Age at last follow-up is not available but can be calculated Y
Sex Y
Ethnicity Y
Years of education Y
Level of education Y
Employment status Y

Physical Health Status

Sub-category Variable type Variables generally collected
Cardiovascular disease data Y
Myocardial infarction Y
Medication use for CVD Y
Hypertension Y
Systolic/Diastolic BP (Some participants) Y
Virus testing Y
Cancer Y
Diabetic Status Y
Stroke data Y
Transient Ischemic Attack Y
Head trauma data: Loss of consciousness Y

Health Care Utilisation

Sub-category Variable type Variables generally collected
Medication use Y
Medication use for CVD Y
Admission to nursing home Y

Life Functionality

Sub-category Variable type Variables generally collected
ADCS-ADL Y
Blessed Dementia Scale Y
Global Deterioration Scale (GDS) Y

Mental Health Status

Sub-category Variable type Variables generally collected
Cornell depression Scale Y
Geriatric Depression Scale (GDS) Y
NPI Y
Apathy evaluation Y
Anxiety measure Y

Cognitive Status

Sub-category Variable type Variables generally collected
Alzheimer's dementia Y
Lewy Body disease Y
Parkinson's disease Y
Frontotemporal dementia Y
Vascular dementia Y
MCI Y

Lifestyle

Sub-category Variable type Variables generally collected
Smoking Y
Current smoking Y
Former smoking Y
Alcohol Y
Abstainers/former users Y
Binge drinking Y

Physical Environment

Sub-category Variable type Variables generally collected
Living situation Y

Physical Examination

Sub-category Variable type Variables generally collected
Blood pressure (Some participants) Y
Weight (Some participants) Y
Height (Some participants) Y
Neurological examination (Some) Y

Digital Phenotyping

Sub-category Variable type Variables generally collected
Verbal Memory Y
Language Y
Vigilance Y
Latent Memory Y
Visuospatial function Y
IQ data Y
NART Y
MMSE Y
MoCA (Some participants) Y
ADAS-Cog (Some participants) Y
Addenbrooke's Cognitive Exam (Some participants) Y
TICs (Some participants) Y
DRS-2 (Some participants) Y
Clinical dementia rating scale (CDR) Y

Biosample Assays

Sub-category Variable type Variables generally collected
Urine Y

Genomics

Sub-category Variable type Variables generally collected
GWAS Y
Whole Exome sequenced Y
APOE genotyped Y
APOE gene screening Y
TREM2 gene screening (some participants) Y

Metabolomics

Sub-category Variable type Variables generally collected
CRP (c-reactive protein) Y
Glucose Y
HbA1c Y
Lipids Y