Cohort Descriptives

Variable Response
Cohort Name Environmental Pollution-Induced Neurological Effects (EPINEF) study
Cohort Acronym EPINEF
DOI Kim, C. (2017). EPINEF [Data set]. Dementias Platform UK. https://doi.org/10.48532/024000
Study Overview 2008 (1st-3rd year), and recruiting is ongoing.
#Subjects at Baseline 2008
Institution Name Yonsei University College of Medicine
Department Name Preventative medicine department
City Seoul, Korea
Principal Investigator (PI) Changsoo Kim
Key Study References

Please see Literature section

Population Based Study? Yes
Family Based Study? No
Clinical based sample? Yes
Is there follow-up data available? No
Were participants included prior to development of dementia (may refer to controls only)? No
Were participants included prior to development of MCI (may refer to controls only)? No
How is data collected? In person
Who carries out data collection? Interviewers and Clinical Staff: Researchers including researching nurse, student researcher.
Does this take place in participants' homes or at a central location? Central
Do participants take part individually or are families/partners involved? Main individually, although some participants take part with their partner.
Dementia cases ascertained as part of study: Yes
Diagnosis based on review of existing clinical data Yes
Was diagnosis/primary outcomes made blind to exposure variables? Yes
How many times followed up? 1
Study start date 1/5/2014 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? Yes
Inclusion criteria Community dwelling people living in specific area. Over 60 years.
Exclusion criteria Past history of dementia, parkinsonism, stroke.

Administration

Variable type
Age At Assessment
Cohort Classification Code
Date Of Birth
Date Of Written Consent
Gender Of Subject
Subject Identification Number
Year Of Assessment

Sociodemographic

Sub-category Variable type Baseline
Deprivation Income level Y
Education Education level Y
Employment Age at retirement Y
Employment Age started current job Y
Employment Age started/stopped longest held job Y
Employment Current job level Y
Employment Longest job held Y
Marital Status Marital status Y
Religion Participates in religious activities more than once a month Y

Family History

Sub-category Variable type Baseline
Extended Family history of angina/myocardial infarction Y
Extended Family history of dementia Y
Extended Family history of diabetes mellitus Y
Extended Family history of hypertension Y
Extended Family history of malgnant cancers Y
Extended Family history of Parkinsonism Y
Extended Family history of stroke Y
Extended Family history of unspecified mental disease Y
Extended Family medical history Y

Physical Health Status

Sub-category Variable type Baseline
Cancer Malignant cancer Y
Cardiothoracic Coronary artery obsructive disorder (eg angina/myocardial infarction) Y
Cardiothoracic Dyslipidemia/hyperlipidemia Y
Cardiothoracic Hypertension Y
Eyes Cataract Y
Eyes Glaucoma Y
General Health Diabetes mellitus Y
General Health Osteoporosis Y
General Health Past medical history Y
General Health Self-rated health Y
Pain Have any pain/discomfort Y
Respiratory Asthma Y
Respiratory Chronic Obstructive Pulmonary Disease (COPD) Y
Rheumatology Osteoarthritis Y

Life Functionality

Sub-category Variable type Baseline
Daily Living Any problems performing usual activities Y
Daily Living Any problems with self care Y

Psychological Status

Sub-category Variable type Baseline
Wellbeing Life satisfaction Y

Mental Health Status

Sub-category Variable type Baseline
Disorders Major depressive disorder Y
Disorders Unspecified mental disease Y
Mood Short version of Geriatric Depression Scale (GDS) Y
Mood Whether anxious/depressed Y

Cognition

Sub-category Variable type Baseline
Cognitive Performance Controlled Oral Word Association Test (COWAT) Y
Cognitive Performance Digit Symbol Coding test (DSC) Y
Cognitive Performance Mini-Mental State Examination (MMSE) Y
Cognitive Performance Montreal Cognitive Assessment (MoCA) Y
Cognitive Performance Rey Complex Figure Test and Recognition Trial (RCFT) Y
Cognitive Performance Seoul Verbal Learning Test (SVLT) Y
Cognitive Performance Stroop test Y
Cognitive Performance Trail Making Test (TMT) Y
Cognitive Status Diagnosis of cognitive disorder Y

Lifestyle

Sub-category Variable type Baseline
Alcohol Number of times drink alcohol per month Y
Alcohol Number of times per month pass out/have memory loss due to drinking Y
Alcohol Number of units drink at a time Y
Alcohol Number of years spent drinking alcohol Y
Alcohol Whether drank alcohol in past year (excluding religious/other ceremonies) Y
Alcohol Whether giving/given up alcohol Y
Alcohol Year stopped drinking alcohol Y
Leisure Charity activities more than once a month Y
Leisure Leisure activities more than once a month Y
Physical Amount of time spent doing brisk walking Y
Physical Amount of time spent on moderate/vigorous physical activity Y
Physical Any problems in walking about Y
Physical Number of times per week does brisk walking Y
Physical Number of times per week does moderate/vigorous physical activity Y
Physical Physical activities more than once a month Y
Smoking Age started smoking Y
Smoking Number of cigarettes smoked daily Y
Smoking Number of years passively smoked for Y
Smoking Number of years since quitting smoking Y
Smoking Number of years smoked for Y
Smoking Whether currently passively smoke Y
Smoking Whether currently smoke Y
Smoking Whether smoked more than 5 packs of cigarettes in lifetime Y

Physical Environment

Sub-category Variable type Baseline
Housing How long lived in current home Y
Housing How often passively smoke at home per week Y
Housing Length of time exposed to secondhand smoke at home in past month Y
Housing Number of family members live with Y
Work How often passively smoke at work per week Y
Work Length of time exposed to secondhand smoke at work per day Y

Social Environment

Sub-category Variable type Baseline
Social Interaction Social activities more than once a month Y

Physical Examination

Sub-category Variable type Baseline
Anthropometry Height Y
Anthropometry Waist circumference Y
Anthropometry Weight Y
Heart Diastolic blood pressure Y
Heart Perfusion index (PI) Y
Heart Systolic blood pressure Y

Biosample Assays

Sub-category Variable type Baseline
Biochemistry Alanine transaminase (ALT) Y
Biochemistry Albumin/microalbumin Y
Biochemistry Alkaline phosphatase (ALP) Y
Biochemistry Aluminium/calcium/lead/manganese/mercury levels Y
Biochemistry Aspartate transaminase (AST) Y
Biochemistry Bilirubin Y
Biochemistry Blood urea nitrogen (BUN) Y
Biochemistry C-reactive protein (CRP) Y
Biochemistry Creatinine Y
Biochemistry Crystals in urine Y
Biochemistry Fasting blood sugar (FBS) Y
Biochemistry Glucose Y
Biochemistry HDL/total cholesterol Y
Biochemistry Hydroxyphenanthrene (OHPHE) Y
Biochemistry Hydroxyprogesterone (OHP) Y
Biochemistry Insulin Y
Biochemistry Ketones Y
Biochemistry Parathyroid hormone (PTH) Y
Biochemistry Phosphates Y
Biochemistry Protein Y
Biochemistry T3/T4 Y
Biochemistry Thyroid-stimulating hormone (TSH) Y
Biochemistry Triglycerides Y
Biochemistry Urinalysis (UA) Y
Biochemistry Urinary casts Y
Biochemistry Urobilinogen Y
Biochemistry Vitamin D Y
Haematology Haematocrit Y
Haematology Haemoglobin/HbA1c Y
Haematology Mean corpuscular haemoglobin (MCH) Y
Haematology Mean corpuscular haemoglobin concentration (MCHC) Y
Haematology Mean corpuscular volume (MCV) Y
Haematology Minimum/maximum epithelial (EP) cells Y
Haematology Minimum/maximum red/white blood cells Y
Haematology Platelets Y
Haematology Red/white blood cells Y
Microbiology Bacteria in blood/urine Y

Imaging

Sub-category Variable type Baseline
MRI Average cerebral cortex thickness measurement w-scores from Inbrain Y
MRI Average cerebral cortex thickness measurements from Inbrain Y
MRI Brain volume measurements Y
MRI Cerebral cortex thickness measurements Y
MRI Estimated Total Intracranial Volume (eTIV) Y
MRI Number of defect holes in surfaces prior to fixing Y
MRI Volume measurement w-scores from Inbrain Y
MRI Volume measurements from Inbrain Y
MRI White matter hypointensity (WMH), from Inbrain Y