Cohort Descriptives

Variable Response
Cohort Name Environmental pollution-induced Neurological Effects (EPINEF) study
Cohort Acronym EPINEF
Study Overview 2008 (1st-3rd year) , and recruting is ongoing.
Institution Name Yonsei University College of Medicine
Department Name Preventive medicine department
City Seoul , Korea
Principal Investigator (PI) Changsoo Kim
Population Based Study? Yes
Family Based Study? No
Clinical based sample? Yes
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? No
Were participants included prior to development of MCI (may refer to controls only)? No
How is data collected? In person
Who carries out data collection? Interviewers and Clinical Staff: Researchers including researching nurse, student researcher
Does this take place in participants' homes or at a central location? Central
Do participants take part individually or are families/partners involved? Main individually, although some participants take part with their partner
Dementia cases ascertained as part of study: Yes
Diagnosis based on review of existing clinical data Yes
Was diagnosis/primary outcomes made blind to exposure variables? Yes
How many times followed up? 2
How regular is follow-up? Every 3 years
Study start date 5/1/2014 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? Yes
Inclusion criteria Community dwelling people living in specific area. Over 60 years.
Exclusion criteria Past history of dementia, parkinsonism, stroke

Administration

Variable type Variables generally collected
Study ID Y
Age Y
Sex Y

Sociodemographic

Variable type Variables generally collected
Age Y
Age at time of diagnosis of dementia Y
Age at last follow-up Y
Sex Y
Ethnicity Y
Years of education Y
Level of education Y
Employment Status Y
Socioeconomic status measures: Income Y

Physical Health Status

Variable type Variables generally collected
Cardiovascular disease data Y
Myocardial infarction Y
Medication Use for CVD Y
Hypertension Y
Systolic/diastolic BP Y
Hypotension Y
Hypercholesterolemia Y
Cancer Y
Diabetic Status Y

Health Care Utilisation

Variable type Variables generally collected
Medication use Y
Medication use for CVD Y

Life Functionality

Variable type Variables generally collected
Global Deterioration Scale (GDS) Y
EQ-5DVAS Y

Psychological Status

Variable type Variables generally collected
Sleep assessment Questionnaires Y
Actigraphy to measure sleep patterns Y

Mental Health Status

Variable type Variables generally collected
Geriatric Depression Scale (GDS) Y

Cognitive Status

Variable type Variables generally collected
Dementia diagnosis Y
Alzheimer's dementia Y
MCI Y

Lifestyle

Variable type Variables generally collected
Smoking Y
Pack years Y
Current smoking Y
Former smoking Y
Alcohol Y
Units per day/week vs weekend Y
Abstainers/former users Y
Physical activity and exercise Y
Type of exercise: heavy, light Y
Exercise duration Y
Occupation possible job matrices Y

Physical Examination

Variable type Variables generally collected
Blood pressure Y
Weight Y
Height Y
BMI Y
Blood lipids Y

Biosample Assays

Variable type Variables generally collected
Plasma Y
Serum Y
Urine Y

Digital Phenotyping

Variable type Variables generally collected
Verbal memory Y
Language Y
Vigilance Y
Latent memory Y
MMSE Y
MoCA Y

Imaging

Variable type Variables generally collected
Structural T1 Y
Fluid attenuation inversion recovery (FLAIR) Y
Diffusion imaging (DTI/DWI) Y
f-MRI (task) Y
f-MRI (rest) Y

Genomics

Variable type Variables generally collected
APOE gene screening (Subgroup - Partially - One subcohort do APOE4 Screening) Y

Metabolomics

Variable type Variables generally collected
CRP (c-reactive protein) Y
eGFR (estimated Glomular Filtration Rate) Y
Glucose Y
HbA1c Y
Lipids Y
Liver Function Tests Y
Serum creatinine Y