Cohort Descriptives

Variable Response
Cohort Name Cambridgeshire Parkinsons Incidence from GP to Neurologist
Cohort Acronym CamPaIGN
Study Overview The CamPaIGN study is a longitudinal study of the natural history of incident Parkinson's disease (PD) patients. The study was the first to prospectively track disease evolution from diagnosis in an unselected population-representative incident cohort, and has focused primarily on the evolution of cognitive dysfunction in PD, reporting on both clinical and genetic predictors of dementia. Other outcomes of interest in this study include development of dyskinesias, development of postural instability, and death.
#Subjects at Baseline 142
Institution Name University of Cambridge
Department Name Clinical Neurosciences, John van Geest Centre for Brain Repair
City Cambridge
Principal Investigator (PI) Prof Roger Barker
Key Study References

Please see Literature Section

Population Based Study? Yes
Family Based Study? No
Clinical based sample? Yes
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? In person
Who carries out data collection? Interviewers and Clinicians: Consultant neurologist and clinical research fellow.
Does this take place in participants' homes or at a central location? Home
Do participants take part individually or are families/partners involved? Individually
Dementia cases ascertained as part of study: Yes
Diagnosis based on review of existing clinical data No
How many times followed up? 5
How regular is follow-up? Every 2-3 years.
Study start date 12/1/2000 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? No
Inclusion criteria Idiopathic PD as identified using UKPDS Brain Bank criteria.

Administration

Variable type Variables generally collected
Study ID Y
Age Y
Sex Y

Sociodemographic

Variable type Variables generally collected
Age Y
Age at time of diagnosis of dementia Y
Age at last follow-up Y
Age at time of death Y
Sex Y
Ethnicity Y
Years of education Y
Employment Status Y

Physical Health Status

Variable type Variables generally collected
Stroke data Y
Transient Ischemic Attack Y

Health Care Utilisation

Variable type Variables generally collected
Medical Use (Drug coding system) Y

Life Functionality

Variable type Variables generally collected
PDQ39 (PD specific) (Repeated collection) Y
UPDRS (PD specific) (Repeated collection) Y
Hoehn and Yahr (PD specific) (Repeated collection) Y
Schwab and England (PD specific) (Repeated collection) Y
Schwab and England scale of functional independence (as part of the UPDRS). Y

Mental Health Status

Variable type Variables generally collected
Beck Depression Inventory Y
NPI Y
Psychiatric evaluations Y

Cognitive Status

Variable type Variables generally collected
Parkinson's Disease Y
MCI Y
Subjective Complaint Y

Lifestyle

Variable type Variables generally collected
Smoking Y
Current smoking Y
Former smoking Y

Physical Environment

Variable type Variables generally collected
Living situation Y

Physical Examination

Variable type Variables generally collected
Extrapyramidal symptoms Y
Gait assessment (As part of UPDRS) Y
Motor phenotype Y
Cardiovascular disease data (from clinical history). Y
Myocardial infarction (from clinical history) Y
Hypertension Y
Cancer (from clinical history) Y
Diabetic Status (from clinical history) Y

Biosample Assays

Variable type Variables generally collected
DNA Y

Digital Phenotyping

Variable type Variables generally collected
Visual Memory Y
Pattern Recognition Memory Y
Visuospatial Function Y
Associative Learning Y
Language Y
Working memory Y
Phonemic fluency Y
Planning Y
IQ data Y
NART Y
MMSE Y

Genomics

Variable type Variables generally collected
APOE Y
MAPT Y
SNCA Y