Cohort Descriptives

Variable Response
Cohort Name Cambridgeshire Parkinsons Incidence from GP to Neurologist
Cohort Acronym CamPaIGN
DOI Barker, R. (2017). CamPaIGN [Data set]. Dementias Platform UK. https://doi.org/10.48532/010000
Study Overview The CamPaIGN study is a longitudinal study of the natural history of incident Parkinson's disease (PD) patients. The study was the first to prospectively track disease evolution from diagnosis in an unselected population-representative incident cohort, and has focused primarily on the evolution of cognitive dysfunction in PD, reporting on both clinical and genetic predictors of dementia. Other outcomes of interest in this study include development of dyskinesias, development of postural instability, and death.
#Subjects at Baseline 142
Institution Name University of Cambridge
Department Name Clinical Neurosciences, John van Geest Centre for Brain Repair
City Cambridge
Study/Database Website

http://www.thebarkerwilliamsgraylab.co.uk/parkinsons-disease/current-studies-pd/

Principal Investigator (PI) Prof Roger Barker
Key Study References

Please see Literature Section

Population Based Study? Yes
Family Based Study? No
Clinical based sample? Yes
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? In person
Who carries out data collection? Interviewers and Clinicians: Consultant neurologist and clinical research fellow.
Does this take place in participants' homes or at a central location? Home
Do participants take part individually or are families/partners involved? Individually
Dementia cases ascertained as part of study: Yes
Diagnosis based on review of existing clinical data No
Was diagnosis/primary outcomes made blind to exposure variables? No
How many times followed up? 4
Study start date 12/1/2000 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? No
Inclusion criteria Idiopathic PD as identified using UKPDS Brain Bank criteria.

Administration

Variable type
Age At Death
Age At Visit
Gender
Mortality Outcome
Participant ID

Sociodemographic

Sub-category Variable type Baseline 1 2 3 4
Education Age left full time education Y        
Education Years of full time education Y        

Early Life History

Sub-category Variable type Baseline 1 2 3 4
Handedness Hand dominance Y        

Physical Health Status

Sub-category Variable type Baseline 1 2 3 4
Cardiothoracic Symptomatic orthostasis Y Y Y Y Y
ENT Difficulty swallowing Y Y Y Y Y
ENT Increased salivation Y Y Y Y Y
General Health Feeling hot/cold Y Y Y Y Y
General Health Nausea Y Y Y Y Y
General Health Number of comorbidities (other than PD) within last 10 years Y        
General Health Number of falls Y Y Y Y Y
General Health Sensory complaints Y Y Y Y Y
Pain Aches and pains Y Y Y Y Y
Pain Muscle cramps Y Y Y Y Y

Healthcare Utilisation

Sub-category Variable type Baseline 1 2 3 4
Medications Levodopa equivalent daily dose Y Y Y Y Y

Life Functionality

Sub-category Variable type Baseline 1 2 3 4
Daily Living PDQ-39 daily living questions Y Y Y Y Y
Daily Living Schwab and England Scale Y Y Y Y Y
Daily Living UPDRS Part II (motor experiences of daily living) Y Y Y Y Y

Psychological Status

Sub-category Variable type Baseline 1 2 3 4
Quality Of Life PDQ-39 quality of life questions Y Y Y Y Y
Sleep Distressing dreams Y Y Y Y Y
Sleep Epworth Sleepiness Scale   Y Y Y Y
Sleep Sleep disturbances Y Y Y Y Y
Sleep Unexpected sleep Y Y Y Y Y
Wellbeing Feel isolated Y Y Y Y Y

Mental Health Status

Sub-category Variable type Baseline 1 2 3 4
Disorders Hallucinations     Y Y Y
Disorders Thought disorders Y Y Y Y Y
Mood Angry/tearful Y Y Y Y Y
Mood Anxiety Y Y Y Y Y
Mood Beck Depression Inventory (BDI) Y Y Y Y Y
Mood Depression Y Y Y Y Y

Cognition

Sub-category Variable type Baseline 1 2 3 4
Cognitive Performance CANTAB tests Y Y Y    
Cognitive Performance Mini-Mental State Exam (MMSE) Y Y Y Y Y
Cognitive Performance National Adult Reading Test (NART) Y        
Cognitive Performance Pentagon Copying Test Y Y Y Y Y
Cognitive Performance Verbal fluency Y Y Y Y Y
Cognitive Status Age at PD diagnosis Y        
Cognitive Status Dementia diagnosis   Y Y Y Y
Cognitive Status Hoehn and Yahr scale Y Y Y Y Y
Cognitive Status PD diagnosis Y Y Y Y Y
Cognitive Status Time from PD diagnosis to visit Y Y Y Y Y
Cognitive Status Time to dementia (years) from diagnosis         Y
Self Report Cognitive Status Memory problems Y Y Y Y Y

Lifestyle

Sub-category Variable type Baseline 1 2 3 4
Leisure Leisure activities Y Y Y Y Y
Smoking Smoking status (current/ex/never) Y        

Social Environment

Sub-category Variable type Baseline 1 2 3 4
Social Interaction Any problems in close relationships Y Y Y Y Y
Social Interaction Support from family/spouse Y Y Y Y Y

Physical Examination

Sub-category Variable type Baseline 1 2 3 4
Mobility Difficulties arising from chair Y Y Y Y Y
Mobility Dyskinesias present Y Y Y Y Y
Mobility Gait test Y Y Y Y Y
Mobility Postural stability Y Y Y Y Y
Mobility UPDRS Part III (motor examination) Y Y Y Y Y
Mobility UPDRS Part IV (motor complications) Y Y Y Y Y