Cohort Descriptives

Variable Response
Cohort Name Cambridge Centre for Ageing and Neuroscience
Cohort Acronym Cam-CAN
Study Overview The aim of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) project is to identify the neural mechanisms underpinning successful cognitive ageing. The study used epidemiological, behavioural, and neuroimaging data to understand how individuals can best retain cognitive abilities into old age. A major aim of the research programme is to understand the nature of brain-cognition relationships across the lifespan, and to highlight the importance of abilities that are maintained into old age. The study was not designed to have repeated measures for each participant, but rather as one extended and comprehensive study visit that took places over 3 stages.
#Subjects at Baseline Approx 2700 had the Stage 1 interview, 700 at Stage 2, 280 at Stage 3.
Institution Name University of Cambridge
Department Name Department of Psychology
City Cambridge
Study/Database Website

http://www.cam-can.com

Principal Investigator (PI) Professor Lorraine Tyler
Key Study References

Available in the Literature section

Population Based Study? Yes
Family Based Study? No
Clinical based sample? No
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? In person
Who carries out data collection? Interviewers
Does this take place in participants' homes or at a central location? Central
Do participants take part individually or are families/partners involved? Individually
Dementia cases ascertained as part of study: No
How many times followed up? 2
Study start date 10/1/2010 12:00:00 AM
Study end date 3/31/2016 12:00:00 AM
Is study ongoing? No
Is study still recruiting? No
Inclusion criteria For Stage 1: Aged 18+ Capacity to consent. Resident within Cambridge City. Not been excluded by GP.Points at the interview where it could be truncated based on tailoring the sample to the inclusion criteria for Stage 2 and 3.
Exclusion criteria For continuation to Stages 2 and 3 : MMSE score 24 or less (calculated in interview). Missing MMSE scores (assumed to be 24 or less). Severe memory defect. Consent difficulties for next stage. Communication difficulties: Hearing problems (difficulty completing interview with hearing aid, inability to hear 35 db at 1000 Hz in either ear in interview functional hearing screening, hearing aid that cannot be removed). Insufficient English language. Vision difficulties (correct near vision of 20/100 or worse with both eyes). Medical problems (self-report of diagnosis): Dementia diagnosis/Alzheimer's Disease. Parkinson's disease. Motor Neurone disease. Multiple Sclerosis. Cancer (history of brain tumour or chemotherapy/radiotherapy for any cancer in last 6 months). Stroke. Encephalitis. Meningitis. Epilepsy. Head injury with serious results (coma, unconscious for >2 hrs, or skull fracture). Recently diagnosed or uncontrolled high blood pressure. Pregnancy or trying to become pregnant. Current serious psychiatric conditions (bipolar disorder, schizophrenia, or psychosis). Mobility problems Restricted mobility which would prevent further participation. Inability to walk 10 metres. Substance abuse: Past or current treatment for drug abuse. Current drug usage. Refusal to answer substance abuse questions. Specific MRI/MEG safety and comfort exclusions: Heart operation. Blood vessel procedure or device (carotid artery vascular clamp, venous umbrella, stent, filter or coil, Swan-Ganz catheter, vascular access ports or catheters). Neurostimulator or spinal fusion stimulator. Electrodes on body, head or brain. Pump, Implant or pacemaker. Brain Operation. Metal splinters in eye, head or ear. Shrapnel, buckshot or bullet in body. Wire sutures or surgical staples. Artificial joints that are MRI incompatible (jaw/maxillary reconstruction, shoulder prosthesis, any other joint replacement surgery in the last 3 months). Bone fixation rods or plates in jaw, head, shoulders or spine. Non-removable dental brace. Non-removable prosthesis or removable eye prosthesis. Inability to lie flat for an hour. Claustrophobia. Body piercings that cannot be removed. IUD that is MRI incompatible. Transdermal delivery patches that cannot be removed. Tattoos on head face or neck.

Administration

Sub-category Variable type Variables generally collected
Study ID Y
Age Y
Sex Y

Sociodemographic

Sub-category Variable type Variables generally collected
Age Y
Age at last follow-up Y
Sex Y
Ethnicity Y
Years of education Y
Level of education Y
Employment Status Y
Socioeconomic status Y

Physical Health Status

Sub-category Variable type Variables generally collected
Cardiovascular disease data (Self-reported) Y
Myocardial infarction (Self-reported) Y
Hypertension (Self-reported) Y
Systolic/diastolic BP (Stages 2 and 3 only) Y
Cancer (Self-report) Y
Diabetic Status (Self-report) Y
Stroke data Y
Head trauma data Y
Loss of consciousness Y

Health Care Utilisation

Sub-category Variable type Variables generally collected
Medication Use Y
Medication use for CVD (Self-reported) Y
Home care-personal care Y
Home care-nursing Y
Permanent stay at nursing home Y
Informal ADL care Y
Informal iADL care Y

Life Functionality

Sub-category Variable type Variables generally collected
Informal ADL care Y
Informal iADL care Y

Psychological Status

Sub-category Variable type Variables generally collected
Activities of Daily Living questions Y
The Lifetime of Experiences Questionnaire (self report) Y
Sleep assessment: Pittsburgh Sleep Quality Index Y
Shift work Y
Sleep problems and patterns Y

Mental Health Status

Sub-category Variable type Variables generally collected
Hospital anxiety depression scale/psychiatry (HADS) Y
Anxiety measure Y

Cognitive Status

Sub-category Variable type Variables generally collected
Parkinson's Disease Y
Subjective Complaint Y
Dementia diagnosis Y

Lifestyle

Sub-category Variable type Variables generally collected
Smoking Y
Pack Years Y
Passive smoking Y
Current smoking Y
Former smoking Y
Alcohol Y
Units per day/week vs weekend Y
Specified beverage type (wine, spirits, beers) Y
Abstainers/former users Y
Drugs of abuse assessment Y
Type of exercise: heavy, light Y
European Prospective Investigation into Cancer Study-Norfolk Physical Activity Questionnaire (EPIC-EPAQ2) Y
Diet: Carbs, protein, fats, fish oil. Y
Coffee and caffeine Y
Food questionnaires Y
Changes to Diet/Diet variability Y
Diet exclusions Y
Sleep assessment: Pittsburg Sleep Quality Index Y

Physical Environment

Sub-category Variable type Variables generally collected
Living situation Y

Social Environment

Sub-category Variable type Variables generally collected
Activities of Daily Living questions Y
The Lifetime of Experiences Questionnaire (self report) Y

Physical Examination

Sub-category Variable type Variables generally collected
Blood pressure (Assessed before onset of dementia) Y
Weight (Assessed before onset of dementia) Y
Height (Assessed before onset of dementia) Y
Heart Rate (Assessed before onset of dementia) Y
ECG (Part of MEG only) Y
Opthalmic examination (Assessed before onset of dementia) Y
Acuity (Assessed before onset of dementia) Y
Colour vision Y
Hearing Y
Self reported general health Y
Chair rises Y
Balance test Y
Falls and mobility Y
BMI Y

Biosample Assays

Sub-category Variable type Variables generally collected
DNA (From saliva not blood) Y
Saliva Y

Digital Phenotyping

Sub-category Variable type Variables generally collected
Visual memory Y
Verbal memory Y
Reaction time Y
Language Y
Planning Y
Self Reported Memory Problems Y
Emotion expression recognition Y
Face recognition Y
Intelligence (IQ per se not measured) Y
MMSE (Repeated collection) Y
Addenbrooke's Cognitive Exam Y

Imaging

Sub-category Variable type Variables generally collected
Structured T1 Y
Fluid attenuation inversion recovery (FLAIR) Y
Diffusion Imaging (DTI/DWI) Y
f-MRI (task) Y
f-MRI (rest) Y
MEG Y
T2-weighted structural image Y
Magnetisation Transfer Ratio (MTR) Y