Cohort Descriptives

Variable Response
Cohort Name The Caerphilly Prospective Study
Cohort Acronym CaPS
Study Overview The Caerphilly Prospective Study (CAPS, also known as the Caerphilly Heart Disease Study), is an epidemiological population study set up to investigate relationships between lifestyle and other factors with incident vascular disease in men. At that time it was only the second population based study in the UK. Phase I began in 1979 until 1983, and Phase IV, the last time the men were examined, was undertaken between 1993 to 1997. Follow up has been carried up through linkage and postal questionnaires. The initial aims of CAPS were to examine the importance of lipids, haemostatic factors, and hormones such as testosterone, cortisol and insulin in the development of heart disease. Other hypotheses were included with a specific interest in platelet function, and psychosocial variables. With the ageing of the cohort, additional outcomes have been included in particular stroke, hearing problems and cognitive function. The CaPS data dictionary is available: https://www.maelstrom-research.org/mica/study/caps
#Subjects at Baseline 2,512 baseline (+ 447 added in Phase II = 2959)
Institution Name University of Bristol
Department Name School of Social and Community Medicine
City Bristol
Study/Database Website

https://www.maelstrom-research.org/mica/study/caps

Principal Investigator (PI) Prof Yoav Ben-Shlomo
Population Based Study? Yes
Family Based Study? No
Clinical based sample? No
Is there follow-up data available? Yes
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? A combination of in person, internet and postal
Who carries out data collection? A Combination of Interviewers and Clinicians
Does this take place in participants' homes or at a central location? Home and Central: Some follow up has been carried out via postal contact
Do participants take part individually or are families/partners involved? Individually
Dementia cases ascertained as part of study: Yes
Diagnosis based on review of existing clinical data Yes
Study start date 7/1/1979 12:00:00 AM
Is study ongoing? Yes
Is study still recruiting? No
Inclusion criteria 45-59 years old. Lives in Caerphilly region . Male. On electoral register and/or general practice list

Administration

Sub-category Variable type Variables generally collected
Study ID Y
Age Y
Sex Y

Sociodemographic

Sub-category Variable type Variables generally collected
Age Y
Age at last follow-up Y
Age at time of death (Mortality flagged data) Y
Sex Y
Ethnicity Y
Years of education Y
Level of education Y
Employment Status Y
Socioeconomic status measures Y

Physical Health Status

Sub-category Variable type Variables generally collected
Cardiovascular disease Y
Myocardial infarction Y
Medication use for CVD Y
Hypertension Y
Systolic/Diastolic BP Y
Hypotension Y
Hypercholesterolemia Y
Cancer Y
Diabetic Status Y
Stroke Y
Stroke Type Y
Transient Ischemic Attack Y
Carotid Plaques Y

Health Care Utilisation

Sub-category Variable type Variables generally collected
Medication use Y
Medication use for CVD Y
Permanent stay at nursing home Y

Psychological Status

Sub-category Variable type Variables generally collected
Personality evaluation Y
Sleep assessment Questionnaires Y

Mental Health Status

Sub-category Variable type Variables generally collected
Psychiatric evaluations Y
Anxiety measure Y

Cognitive Status

Sub-category Variable type Variables generally collected
Alzheimer's dementia Y
Vascular dementia Y
MCI Y
Subjective complaint Y
Clinical Dementia Rating Scale (CDR) Y
IQCODE Y

Lifestyle

Sub-category Variable type Variables generally collected
Smoking Y
Current smoking Y
Former smoking Y
Alcohol Y
Specific beverage type (Wine, spirits, beers) Y
Abstainers/former users Y
Alcohol use (Cage Questionnaire) Y
Binge drinking Y
BMI Y
Hip/waist circumference Y
Fat Percentage Y
Dyslipidemia Y
Blood lipids Y
Metabolic syndrome Y
Type of exercise, Light/Heavy Y
Exercise duration Y
Leisure time physical activity questionnaire Y
Diet Y
Carbs/protein/fats/fish oil Y
Anti-oxidants (Antioxidant enzymes measured in fasted blood) Y
Vegetarian? Y
Shortage of food Y
Vitamin A/B/E Y
Fat intake MUFA/PUFA Y
Food questionnaires Y
Food Frequency Questionnaire items Y
Sleep assessment Questionnaires Y

Physical Environment

Sub-category Variable type Variables generally collected
Living Situation Y

Physical Examination

Sub-category Variable type Variables generally collected
Blood pressure (assessed before onset of dementia) Y
Weight (assessed before onset of dementia) (also, birthweight) Y
Height (assessed before onset of dementia) Y
Anthropometry (Skin folds) Y
ECG (assessed before onset of dementia) Y
Cardiovascular examination (assessed before onset of dementia) Y
Respiratory examination (assessed before onset of dementia) Y
PEFR (assessed before onset of dementia) Y
Spriometry (assessed before onset of dementia) Y
Opthalmic examination (assessed before onset of dementia) Y
LSHTM chest pain questionnaire Y
Health attitude inventory (HAI) Y
Hearing Y
Noise exposure Y
Noise sensitivity Y

Biosample Assays

Sub-category Variable type Variables generally collected
Plasma (Repeated collection) Y
Serum (Repeated collection) Y
DNA (Repeated collection) Y
Cortisol (Repeated collection - Bloods) Y
Oxidative stress Y

Digital Phenotyping

Sub-category Variable type Variables generally collected
Reaction time Y
Language Y
IQ data Y
NART Y
AH4 (fluid intelligence) Y
MMSE (Repeated collection) Y
Cambridge Cognitive Examination (CAMCOG) Y
CDR Y

Metabolomics

Sub-category Variable type Variables generally collected
Glucose (Repeated collection) Y
HbA1c (Repeated collection) Y
Lipids (Repeated collection) Y
Liver Function Tests (Repeated collection) Y
Serum creatinine (Repeated collection) Y
Homocysteine (Repeated collection) Y
Folate Y