Cohort Descriptives

Variable Response
Cohort name Emory Healthy Ageing Study
Cohort acronym EHAS
General Study Overview The Emory Healthy Aging Study is the largest clinical research study targeting Atlanta ever conducted at Emory University. It is a game changing effort to further our scientific understanding of how we age, and to learn more about diseases that occur more commonly in later years. The Emory Healthy Aging Study hopes to build an extremely large database by recruiting a large number of participants to take part in the study over a long period of time. We will keep involvement as simple and easy as possible. The data we collect may help you and your physician learn more about your overall health.
The Emory Healthy Aging Study researches how we age, and focuses on age-related diseases, including Alzheimer’s disease, cardiovascular disease, diabetes, and cancer.
Institution name Emory University
Department name Emory Brain Health Center
City Atlanta, Georgia, USA
Study or database website

Principal Investigator (PI): Name Dr James Lah
PI: Address 12 Executive Park Drive NE, Atlanta, GA, USA
PI: email

PI: phone +14047273509
Administrative Contact (AC): Name Petek Ozgul
AC: Address 12 Executive Park Drive NE, Atlanta, GA, USA
AC: email
Technical Contact/Data manager (TC): Name Aditya Singh Bisht
TC: Address 12 Executive Park Drive NE, Atlanta, GA, USA
TC: email

TC: phone +14047780231
Population based study? Yes
Family based study? No
Clinical based sample? No
Is there follow-up data available? No
Were participants included prior to development of dementia (may refer to controls only)? Yes
Were participants included prior to development of MCI (may refer to controls only)? Yes
How is data collected? In person
Who carries out data collection? Interviewers
Clinical staff
Does this take place in participants' homes or at a central location? Home
Central: Online and at clinics
Do participants take part individually or are families/partners involved? Individually
Dementia cases ascertained as part of study: Yes
Diagnosis based on review of existing clinical data No
Was diagnosis/primary outcomes made blind to exposure variables? No
Is study ongoing? Yes
Is study still recruiting? Yes

Demographic and Clinical Information

Variable Response
Age No
Age at time of diagnosis of dementia Yes
Age at last follow-up No
Age at time of death No
Sex Yes
Ethnicity Yes
Education Yes
Physical examinations
Any physical examination performed? No
Medical conditions
Cardiovascular disease data Yes
Myocardial infarction Data available
Medication use for CVD Data available
Hypertension Data available
Hypercholesterolemia Yes
Medication use Yes
Cancer Data available
Diabetic Status Data available

Cognitive Outcomes

Variable Response
Any domain-specific cognitive test performed? No
IQ data available? No
Cognitive background? Yes
Years of education Yes
Level of education Yes
Parental education No
Standard dementia global cognition scales? No
Addenbrooke's Cognitive Exam No
3MS No

Non-Cognitive Clinical Outcomes

Variable Response
Dementia diagnosis
Alzheimer's dementia Yes
Lewy Body Disease No
Huntingtons Disease No
Parkinsons Disease Yes
Subjective complaint Yes
Dementia diagnosis (Other comments) Information from electronic medical records
Functional rating scales
Any information on dementia rating collected? No
PDQ39 (PD specific) No
UPDRS (PD specific) No
Hoehn and Yahr (PD specific) No
Schwab and England (PD specific) No
UHDRS (HD specific) No
Any information on subjective complaints collected? Yes
Any neuropsychiatric rating scale administered? No
Any Quality of Life Data Colllected? No
Any information on Caregivers and Caregiving Collected? No
Health service utilisation
Any Health Resource Utilisation Collected ? No
Other neurological or psychiatric measurements? Yes
Any stroke data? Yes
Transient Ischemic Attack Yes
Any head trauma data? Yes
Loss of consciousness Yes
BISQ or equivalent Yes


Variable Response
For imaging data, what format(s) do you use for storing data? N/A


Variable Response
Number Gwas subjects N/A
Gene screening

Biological samples

Variable Response
Blood collected No
Plasma No
Serum No
Abeta 1-40 No
Abeta 1-42 No
Abeta x-40 No
Abeta x-42 No
Blood Metabolic Analytes
CRP (c-reactive protein) No
eGFR (estimated Glomular Filtration Rate) No
Glucose No
HbA1c No
Lipids No
Liver Function Tests No
Serum creatinine No
Homocysteine No
Folate No
Other blood samples No
Are laboratory protocols and storage information available for bloods No
Urine collection
Urine No
Autopsy data
Autopsy No
Measurements already performed No
Saliva collected No
Cortisol No
CSF collected No
CSF Abeta No
CSF tau No
Are CSF laboratory protocols and storage information available? No
Mitochondrial function Comments
mtDNA abnormalities No
Oxidative stress No
synuclein No

Brain donation

Variable Response
Is brain donation part of the existing protocol? No
Are information sheets made available to representative or consultees? Yes
Are retrospective interviews carried out after the participant's death? No
Is there a procedure for declining donation/failed recruitment/project termination? Yes
Has an actuarial analysis been completed? No


Variable Response
Smoking Yes
Pack years Data available
Current smoking Data available
Former smoking Data available
Alcohol Data available
Units per day/week vs weekend Data available
Abstainers/former users Data available
Binge drinking Data available
Drugs of abuse assessment
Obesity and associated risk factors
BMI Data available
Blood lipids Data available
Physical activity and exercise Yes
Type of exercise: heavy, light Data available
Exercise duration Data available
Objective measures of activity Data available
Diet Yes
Employment status
Employment status Data available
Living situation
Socioeconomic status
Socioeconomic status measures Data available
Sleep assessment
Questionnaires Data available

Ethics and Engagement

Variable Response
Participant engagement
Is there participant representation in the governance of the cohort? No
Do existing mechanisms for consulting/involving participants exist? Yes
If so, does this happen on an ongoing or an ad hoc basis? Both
Is there an ethics advisory or ELSI group within the cohort governance? Yes
Does the cohort include participants who lack capacity? No
Is there a process in place for participants who lose capacity? No
Do participants provide contact information for a person to act as a potential consultee? Yes
Do procedures exist for the disclosure of incidental findings? No
What kinds of finding do these relate to? (imaging, genotyping, etc) N/A
Who is responsible for disclosing incidental findings? N/A
Do procedures exist for the disclosure of clinically relevant information identified as a direct focus of the study? (e.g. a diagnosis of dementia) Yes
How was the cohort recruited (NHS or not, primary or secondary care)? Multiple care settings
Does the study involve ongoing connections with participants' own doctors (e.g. GPs)? No
Consent and recontact
Is there consent for recontact? Yes
If so, under what conditions? Longitudinal cohort study

Data Management

Variable Response
Consent for linkage to routine data